Journal ArticleDOI
Multiplexed Electrospray Enables High Throughput Production of cGAMP Microparticles to Serve as an Adjuvant for a Broadly Acting Influenza Vaccine.
Cole J. Batty,Matthew D. Gallovic,Jonathan Williams,Ted M. Ross,Eric M. Bachelder,Kristy M. Ainslie +5 more
TLDR
In this paper , the stimulator of interferon genes (STING) agonist cyclic dinucleotide 3'3'-cyclic guanosine monophosphate-adenosine monosphate (cGAMP) was encapsulated in acetalated dextran (Ace-DEX) microparticles through electrospray.About:
This article is published in International Journal of Pharmaceutics.The article was published on 2022-05-01. It has received 5 citations till now. The article focuses on the topics: Medicine & Adjuvant.read more
Citations
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Journal ArticleDOI
Sustained Delivery of CpG Oligodeoxynucleotide by Acetalated Dextran Microparticles Augments Effector Response to Computationally Optimized Broadly Reactive Antigen (COBRA) Influenza Hemagglutinin.
Cole J. Batty,Eva Alice Amouzougan,Michael Allen Carlock,Ted M. Ross,Eric M. Bachelder,Kristy M. Ainslie +5 more
TL;DR: In this article , electrospray was used to encapsulate the hydrophilic adjuvant CpG into microparticles made from a hydrophobic biodegradable polymer acetalated dextran.
Journal ArticleDOI
Hybrid Systems of Nanofibers and Polymeric Nanoparticles for Biological Application and Delivery Systems
Hever Yuritzy Vargas-Molinero,Aracely Serrano-Medina,Kenia Palomino-Vizcaino,Eduardo Alberto López-Maldonado,Luis Jesús Villarreal-Gómez,Graciela Lizeth Pérez-González,José Manuel Cornejo-Bravo +6 more
TL;DR: In this paper , a review summarizes the hybrid systems of polymeric nanoparticles and polymeric nanofibers, critically analyzing how the combination improves the properties of the materials and contributes to the reduction of some disadvantages found in nanometric devices and systems.
Journal ArticleDOI
Vinyl Sulfone-functionalized Acetalated Dextran Microparticles as a Subunit Broadly Acting Influenza Vaccine
Cole J. Batty,Liubov M. Lifshits,Dylan Hendy,Meital Eckshtain-Levi,Luis Alberto Ontiveros-Padilla,Michael A. Carlock,Ted M. Ross,Eric M. Bachelder,Kristy M. Ainslie +8 more
TL;DR: In this article , the ACE-DEX microparticles (MPs) were used to conjugate COBRA to the surface and encapsulate the STING agonist cGAMP to form a broadly active influenza vaccine.
Journal ArticleDOI
Humoral Response to the Acetalated Dextran M2e Vaccine is Enhanced by Antigen Surface Conjugation.
Cole J. Batty,Erik S Pena,Eva Alice Amouzougan,Kathryn B. Moore,Kristy M. Ainslie,Eric M. Bachelder +5 more
TL;DR: In this paper , the authors showed the utility of conjugating M2e to the surface of a particle carrier to increase its immunogenicity for use as the antigen in a universal influenza vaccine.
References
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Journal ArticleDOI
Estimates of global seasonal influenza-associated respiratory mortality: a modelling study
A. Danielle Iuliano,Katherine Roguski,Howard H. Chang,David Muscatello,Rakhee Palekar,Stefano Tempia,Cheryl Cohen,Jon Michael Gran,Jon Michael Gran,Dena L. Schanzer,Benjamin J. Cowling,Peng Wu,Jan Kynčl,Li Wei Ang,Minah Park,Monika Redlberger-Fritz,Hongjie Yu,Laura Espenhain,Anand Krishnan,Gideon O. Emukule,Liselotte van Asten,Susana Silva,Suchunya Aungkulanon,Udo Buchholz,Marc-Alain Widdowson,Joseph S. Bresee,Eduardo Azziz-Baumgartner,Po-Yung Cheng,Fatimah S. Dawood,Ivo M. Foppa,Sonja J. Olsen,Michael Haber,Caprichia Jeffers,C. Raina MacIntyre,Anthony T. Newall,James G. Wood,Michael Kundi,Therese Popow-Kraupp,Makhdum Ahmed,Mahmudur Rahman,Fatima Marinho,C Viviana Sotomayor Proschle,Natalia Vergara Mallegas,Feng Luzhao,Li Sa,Juliana Barbosa-Ramírez,Diana Malo Sanchez,Leandra Abarca Gomez,Xiomara Badilla Vargas,aBetsy Acosta Herrera,María Josefa Llanés,Thea Kølsen Fischer,Tyra Grove Krause,Kåre Mølbak,Jens Nielsen,Ramona Trebbien,Alfredo Bruno,Jenny Ojeda,Hector Ramos,Matthias an der Heiden,Leticia del Carmen Castillo Signor,Carlos Enrique Serrano,Rohit Bhardwaj,Mandeep S. Chadha,Venkatesh Vinayak Narayan,Soewarta Kosen,Michal Bromberg,Aharona Glatman-Freedman,Zalman Kaufman,Yuzo Arima,Kazunori Oishi,Sandra S. Chaves,Bryan O. Nyawanda,Reem Abdullah Al-Jarallah,Pablo A Kuri-Morales,Cuitláhuac Ruiz Matus,Maria Eugenia Jimenez Corona,Alexander Burmaa,Oyungerel Darmaa,Majdouline Obtel,Imad Cherkaoui,Cees C van den Wijngaard,Wim van der Hoek,Michael G Baker,Don Bandaranayake,Ange Bissielo,Sue Huang,Liza Lopez,Claire Newbern,Elmira Flem,Gry M Grøneng,Siri Hauge,Federico G de Cosío,Yadira De Molto,Lourdes Moreno Castillo,María Agueda Cabello,Marta Von Horoch,José L. Medina Osis,Ausenda Machado,Baltazar Nunes,Ana Paula Rodrigues,Emanuel Rodrigues,Cristian Calomfirescu,Emilia Lupulescu,Rodica Popescu,Odette Popovici,Dragan Bogdanovic,Marina Kostic,Konstansa Lazarevic,Zoran Milosevic,Branislav Tiodorovic,Mark I-Cheng Chen,Jeffery Cutter,Vernon J. Lee,Raymond T. P. Lin,Stefan Ma,Adam L. Cohen,Florette K. Treurnicht,Woo Joo Kim,Concha Delgado-Sanz,Salvador de mateo Ontañón,Amparo Larrauri,Inmaculada León,Fernando Vallejo,Rita Born,Christoph Junker,Daniel Koch,Jen-Hsiang Chuang,Wan-Ting Huang,Hung-Wei Kuo,Yi-Chen Tsai,Kanitta Bundhamcharoen,Malinee Chittaganpitch,Helen K. Green,Richard Pebody,Natalia Goñi,Hector Chiparelli,Lynnette Brammer,Desiree Mustaquim +138 more
TL;DR: These global influenza-associated respiratory mortality estimates are higher than previously reported, suggesting that previous estimates might have underestimated disease burden.
Journal ArticleDOI
The Innate Immune DNA Sensor cGAS Produces a Noncanonical Cyclic Dinucleotide that Activates Human STING
Elie J. Diner,Dara Burdette,Stephen C. Wilson,Kathryn M. Monroe,Colleen A. Kellenberger,Mamoru Hyodo,Yoshihiro Hayakawa,Ming C. Hammond,Russell E. Vance +8 more
TL;DR: Natural variants of human STING (hSTING) are identified that are poorly responsive to cGAMP yet, unexpectedly, are normally responsive to DNA and cGAS signaling, which indicates that hSTING variants have evolved to distinguish conventional (3'-5') cyclic dinucleotides from the noncanonical cyclic Dinucleotide produced by mammalian cGAS.
Journal ArticleDOI
Type I interferons produced by dendritic cells promote their phenotypic and functional activation.
Maria Montoya,Giovanna Schiavoni,Fabrizio Mattei,Ion Gresser,Filippo Belardelli,Persephone Borrow,David F. Tough +6 more
TL;DR: It is shown that murine DCs undergo phenotypic maturation upon exposure to type I interferons (type I IFNs) in vivo or in vitro, identifying type Iinterferons as autocrine DC activators.
Journal ArticleDOI
A statistically defined endpoint titer determination method for immunoassays
TL;DR: A practical method for establishing a statistically valid cutoff for endpoint titers of immunoassays which is more reliable than other nonstatistical procedures yet does not require sophisticated computation.
Journal ArticleDOI
Variable influenza vaccine effectiveness by subtype: a systematic review and meta-analysis of test-negative design studies
Edward A. Belongia,Melissa Simpson,Jennifer P. King,Maria E. Sundaram,Nicholas S. Kelley,Michael T. Osterholm,Huong Q. McLean +6 more
TL;DR: A systematic review and meta-analysis of Influenza vaccine effectiveness (VE) found vaccines provided substantial protection against H1N1pdm09, H1n1 (pre-2009), and type B, and reduced Protection against H3N2.
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