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Open AccessJournal ArticleDOI

Multipoint maximum likelihood mapping in a full-sib family of an outbreeding species.

J.W. van Ooijen
- 01 Oct 2011 - 
- Vol. 93, Iss: 5, pp 343-349
TLDR
The fast multipoint maximum likelihood mapping algorithm for crosses between inbred lines, introduced by Jansen et al. ( 2001), is extended for mapping in a full-sib family of an out breeding species to enable a more accurate estimation of maps in outbreeding species than current methods.
Abstract
The fast multipoint maximum likelihood mapping algorithm for crosses between inbred lines, introduced by Jansen et al. (2001), is extended for mapping in a full-sib family of an outbreeding species. The method accommodates different segregation types of markers and differences in recombination between parents. The two separate parental multipoint maximum likelihood maps are joined into an integrated map by averaging lengths over anchored segments and by interpolating or extrapolating for markers segregating in one parent only. The method is illustrated with simulated data. The method will enable a more accurate estimation of maps in outbreeding species than current methods.

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A heterozygous moth genome provides insights into herbivory and detoxification

TL;DR: The first whole-genome sequence of a basal lepidopteran species, Plutella xylostella, is reported, which contains 18,071 protein-coding and 1,412 unique genes with an expansion of gene families associated with perception and the detoxification of plant defense compounds.
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ALLMAPS: robust scaffold ordering based on multiple maps

TL;DR: AllMAPS is a method capable of computing a scaffold ordering that maximizes colinearity across a collection of maps, which is robust against common mapping errors, and generates sequences that are maximally concordant with the input maps.
Journal ArticleDOI

Lep-MAP3: robust linkage mapping even for low-coverage whole genome sequencing data.

TL;DR: The software Lep-MAP3, capable of mapping high-throughput whole genome sequencing datasets, obtains very good performance already on 5x sequencing coverage and outperforms the fastest available software on simulated data on accuracy and often on speed.
References
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Journal ArticleDOI

Optimization by Simulated Annealing

TL;DR: There is a deep and useful connection between statistical mechanics and multivariate or combinatorial optimization (finding the minimum of a given function depending on many parameters), and a detailed analogy with annealing in solids provides a framework for optimization of very large and complex systems.

Software for the calculation of genetic linkage maps in experimental populations

TL;DR: JoinMap is developed by Kyazma B.V. in collaboration with statistical geneticists of Biometris of Wageningen UR (www.biometris.wur.nl) and aims to provide real-time information about gene expression in the population to facilitate informed decision-making.
Journal ArticleDOI

Construction of multilocus genetic linkage maps in humans.

TL;DR: Several alternative algorithms for constructing human linkage maps given a specified gene order are described, one of which allows maximum-likelihood multilocus linkage maps for dozens of DNA markers in such three-generation pedigrees to be constructed in minutes.
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