Journal ArticleDOI
Mutation of the mouse klotho gene leads to a syndrome resembling ageing
Makoto Kuro-o,Matsumura Yutaka,Hiroki Aizawa,Hiroshi Kawaguchi,Tatsuo Suga,Toshihiro Utsugi,Yoshio Ohyama,Masahiko Kurabayashi,Tadashi Kaname,Eisuke Kume,Hitoshi Iwasaki,Akihiro Iida,Takako Shiraki-Iida,Satoshi Nishikawa,Ryozo Nagai,Ryozo Nagai,Yo-ichi Nabeshima +16 more
TLDR
A new gene, termed klotho, has been identified that is involved in the suppression of several ageing phenotypes in the mouse, and may function as part of a signalling pathway that regulates ageing in vivo and morbidity in age-related diseases.Abstract:
A new gene, termed klotho, has been identified that is involved in the suppression of several ageing phenotypes. A defect in klotho gene expression in the mouse results in a syndrome that resembles human ageing, including a short lifespan, infertility, arteriosclerosis, skin atrophy, osteoporosis and emphysema. The gene encodes a membrane protein that shares sequence similarity with the β-glucosidase enzymes. The klotho gene product may function as part of a signalling pathway that regulates ageing in vivo and morbidity in age-related diseases.read more
Citations
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Journal ArticleDOI
Protective effect of Polygonatum sibiricum Polysaccharide on D-galactose-induced aging rats model.
TL;DR: It is found that PSP could significantly improve the learning and memory abilities of rats and reverse the pathological changes of kidney tissues in rats.
Book ChapterDOI
Mouse models and aging: longevity and progeria.
Chen-Yu Liao,Brian K. Kennedy +1 more
TL;DR: Aging is a complex, multifactorial process that is likely influenced by the activities of a range of biological pathways Genetic approaches to identify genes modulating longevity have been highly successful and recent efforts have extended these studies to mammalian aging as mentioned in this paper.
Book ChapterDOI
Parathyroid function in chronic kidney disease: role of FGF23-Klotho axis.
TL;DR: The pathogenesis of secondary hyperparathyroidism is discussed, particularly focusing on the emerging role of the FGF23-Klotho axis in patients with CKD, with implications for the deeper understanding of disordered mineral metabolism in CKD.
Journal ArticleDOI
Association of the F352V variant of the Klotho gene with bone mineral density
José A. Riancho,Carmen Valero,José L. Hernández,Fernando Rosell Ortiz,Ana Zarrabeitia,María A. Alonso,Nicolás Peña,M. Asunción Pascual,Jesús González-Macías,María T. Zarrabeitia +9 more
TL;DR: The F352V Klotho polymorphism is associated with BMD in postmenopausal women, suggesting that Klotha gene variants influence skeletal aging.
Journal ArticleDOI
Daily and seasonal mitochondrial protection: Unraveling common possible mechanisms involving vitamin D and melatonin
TL;DR: The primary purpose of this review is to elucidate the common molecular mechanisms by which vitamin D and melatonin might share a synergistic effect in the protection of proper mitochondrial functioning.
References
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TL;DR: Lower Organisms: Identification of Longevity, Neurobiological Correlates of Age-Related Cognitive Decline: Animal Models, and Mechanisms Controlling in Vitro Cellular Senescene.