Journal ArticleDOI
Neuregulin-1 is neuroprotective and attenuates inflammatory responses induced by ischemic stroke
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TLDR
It is shown that a single intravascular injection of neuregulin-1beta reduced cortical infarct volume by >98% when given immediately before middle cereral artery occlusion, and that this effect protects neurons from delayed, ischemia-induced apoptotic cell death in the cortex by inhibiting pro-inflammatory responses.About:
This article is published in Biochemical and Biophysical Research Communications.The article was published on 2004-09-17. It has received 95 citations till now. The article focuses on the topics: Penumbra & Ischemia.read more
Citations
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Neuregulin in Cardiovascular Development and Disease
TL;DR: A conceptual model in which a key function of NRG-1/ErbB signaling is to mediate adaptations of the heart to physiological and pathological stimuli through activation of intracellular kinase cascades that regulate tissue plasticity is suggested.
Journal ArticleDOI
Cytokines and Perinatal Brain Damage
Olaf Dammann,T. Michael O'Shea +1 more
TL;DR: Evidence that infection outside of the brain can damage the brain is reviewed, and specific cytokines and pathomechanisms that probably mediate the putative effect of remote infection on the developing brain are discussed.
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Neuregulins: versatile growth and differentiation factors in nervous system development and human disease.
TL;DR: The basic biology of neuregulins is reviewed and this to research suggesting their involvement with and potential therapeutic uses for neurological disorders is related.
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Specific Regulation of NRG1 Isoform Expression by Neuronal Activity
Xihui Liu,Ryan Bates,Dong Min Yin,Chengyong Shen,Fay Wang,Nan Su,Sergei A. Kirov,Yuling Luo,Jian-Zhi Wang,Wen Cheng Xiong,Lin Mei +10 more
TL;DR: It is found that each of the six types of NRG1 has a distinct expression pattern in the brain at different ages, resulting in a change inNRG1 isoform composition, which may contribute to versatile functions of NRg1 and pathologic mechanisms of brain disorders such as schizophrenia.
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VEGF Signaling in Neurological Disorders
Joon W. Shim,Joseph R. Madsen +1 more
TL;DR: A recent update on causes of death due to neurological disorders involving cerebrovascular and age-related neurological conditions and to understand the mechanism by which angiogenesis-dependent pathological events can be treated with VEGF antagonisms are included.
References
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Journal ArticleDOI
NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses
TL;DR: Recently, significant advances have been made in elucidating the details of the pathways through which signals are transmitted to the NF-kappa B:I kappa B complex in the cytosol and their implications for the study of NF-Kappa B.
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Pathobiology of ischaemic stroke: an integrated view
TL;DR: This article provides a framework that can be used to generate testable hypotheses and treatment strategies that are linked to the appearance of specific pathophysiological events within the ischaemic brain.
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Inflammatory mediators and stroke: new opportunities for novel therapeutics.
TL;DR: The realization that brain ischemia and trauma elicit robust inflammation in the brain provides fertile ground for discovery of novel therapeutic agents for stroke and neurotrauma and inhibition of the mitogen-activated protein kinase (MAPK) cascade via cytokine suppressive anti-inflammatory drugs are most promising new opportunities.
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Inflammation and glial responses in ischemic brain lesions
TL;DR: It is unclear whether detrimental effects of inflammation outweigh neuroprotective mechanisms or vice versa, and in global ischemia inflammatory responses are limited, but micro- and astroglia are also strongly activated.
Journal ArticleDOI
Middle Cerebral Artery Occlusion in the Rat by Intraluminal Suture Neurological and Pathological Evaluation of an Improved Model
TL;DR: Reversible MCAo in which a poly-L-lysine-coated intraluminal suture was used proved to be a reliable and effective modification of this technique, yielding consistently larger infarcts and greatly reduced interanimal variability.
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