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Neurophysiology and neuropharmacology of cardiovascular regulation and stress

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TLDR
The conclusion is reached that further multidisciplinary research will reveal underlying neurophysiological and neuropharmacological mechanisms responsible for stress induced cardiovascular disease and lead to new methods of treatment.
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This article is published in Neuroscience & Biobehavioral Reviews.The article was published on 1981-03-01. It has received 121 citations till now.

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Journal ArticleDOI

How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions.

TL;DR: This review considers recent findings regarding GC action and generates criteria for determining whether a particular GC action permits, stimulates, or suppresses an ongoing stress-response or, as an additional category, is preparative for a subsequent stressor.
Journal ArticleDOI

Autonomic determinism: the modes of autonomic control, the doctrine of autonomic space, and the laws of autonomic constraint.

TL;DR: A formal 2-dimensional conception of autonomic space is proposed, and a quantitative model for its translation into a functional output surface is derived and has fundamental implications for the direction and interpretation of a wide array of psychophysiological studies.
Journal ArticleDOI

Interactions Between Cardiovascular and Pain Regulatory Systems

TL;DR: The present analysis suggests that the inhibition of pain brought about by elevations in either arterial or venous blood pressure may provide a form of psychophysiological relief under situations of stress and contribute to the development of essential hypertension in humans.
Journal ArticleDOI

Afferent and efferent connections of the A5 noradrenergic cell group in the rat.

TL;DR: In this article, the supraspinal afferent and efferent connections of the A5 noradrenergic cell group were examined in rats and very small deposits of HRP-WGA were made in the rostral A5 area.
References
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Journal ArticleDOI

The spinal connections of the inspiratory neurones of the ventrolateral nucleus of the cat's tractus solitarius

TL;DR: Critically time-controlled collision tests showed that there was a period after a spontaneous spike during which a stimulus applied to the spinal cord was ineffective in eliciting a response in the TS neurone, and spinal driving of the cell at a time slightly longer than the critical delay could not be due to antidromic activation but was transmitted by an orthodromic pathway.
Book ChapterDOI

Central inhibitory noradrenergic cardiovascular control.

TL;DR: This chapter presents several experiments that indicate that the central hypotensive effect of L-DOPA (L- 3,4-dihydroxyphenylalanin) may be related to an increase of brain stem noradrenaline level, and investigates the cardiovascular effect of bilateral electrolytic brain stem lesions at the level of the obex in rats anesthetized with ether.
Journal ArticleDOI

Cardiovascular responses to electrical stimulation of the amygdala in the rat

TL;DR: It is suggested that the amygdala exerts complex modulatory influences in the control of the cardiovascular system and that its role will be understood by considering these fragmentary responses elicited in acute experimental conditions in relation to the cardiovascular changes observed in various natural behavioral states.
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