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Neurophysiology and neuropharmacology of cardiovascular regulation and stress

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TLDR
The conclusion is reached that further multidisciplinary research will reveal underlying neurophysiological and neuropharmacological mechanisms responsible for stress induced cardiovascular disease and lead to new methods of treatment.
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This article is published in Neuroscience & Biobehavioral Reviews.The article was published on 1981-03-01. It has received 121 citations till now.

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How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions.

TL;DR: This review considers recent findings regarding GC action and generates criteria for determining whether a particular GC action permits, stimulates, or suppresses an ongoing stress-response or, as an additional category, is preparative for a subsequent stressor.
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Autonomic determinism: the modes of autonomic control, the doctrine of autonomic space, and the laws of autonomic constraint.

TL;DR: A formal 2-dimensional conception of autonomic space is proposed, and a quantitative model for its translation into a functional output surface is derived and has fundamental implications for the direction and interpretation of a wide array of psychophysiological studies.
Journal ArticleDOI

Interactions Between Cardiovascular and Pain Regulatory Systems

TL;DR: The present analysis suggests that the inhibition of pain brought about by elevations in either arterial or venous blood pressure may provide a form of psychophysiological relief under situations of stress and contribute to the development of essential hypertension in humans.
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Afferent and efferent connections of the A5 noradrenergic cell group in the rat.

TL;DR: In this article, the supraspinal afferent and efferent connections of the A5 noradrenergic cell group were examined in rats and very small deposits of HRP-WGA were made in the rostral A5 area.
References
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Hypertension after localized transection of brainstem fibres

TL;DR: The results of this study suggest that the fibres involved are entering the NTS laterally and that deafferentation of the cells of this nucleus results in hypertension by removing an inhibitory central control.
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Activation of cardiac vagal receptors during myocardial ischemia.

TL;DR: La décharge de fibres vagales d'origine cardiaque est augmentée au cours d'une réduction du flux sanguin dans l'artère coronaire de gauche lorsque le coeur est déjà défaillant à cause of l'ichémie.
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Orbital cortical influences on cardiovascular dynamics and myocardial structure in conscious monkeys.

TL;DR: Cardiovascular changes induced by stimulating the orbital cortex suggest a pathophysiological mechanism whereby emotional expression may effect dynamic shifts in cardiovascular functions and may thus induce permanent and manifest myocardial lesions.
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