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Neurophysiology and neuropharmacology of cardiovascular regulation and stress

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TLDR
The conclusion is reached that further multidisciplinary research will reveal underlying neurophysiological and neuropharmacological mechanisms responsible for stress induced cardiovascular disease and lead to new methods of treatment.
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This article is published in Neuroscience & Biobehavioral Reviews.The article was published on 1981-03-01. It has received 121 citations till now.

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Habituation of the cardiac response to involuntary diving in diving and dabbling ducks

TL;DR: The changes in blood gases during dives by naive and habituated dabbling ducks were the same: therefore, in the absence of a demonstrated decrement in receptor chemosensitivity or efferent potency, the locus of habituation must reside in the central nervous system.
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N-Methyl-D-aspartate receptor blockade by dizocilpine prevents stress-induced sudden death in cardiomyopathic hamsters.

TL;DR: It is suggested that NMDA receptors have an important role in stress-induced sudden death in cardiomyopathic hamsters and the first evidence for the potential therapeutic value of NMDA antagonists against cardiac sudden death is provided.
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Effects of stimulation of the mediodorsal nucleus and its projection cortex on heart rate in the rabbit

TL;DR: Large bradycardiac responses were obtained in an unanesthetized preparation to both MD stimulation and to sensory stimuli, suggesting a possible physiological correlate for these intracranially-evoked heart rate changes.
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Evidence that imipramine‐induced postural hypotension may be centrally mediated

TL;DR: Neither dose had an appreciable effect upon respiratory sinus arrhythmia (RSA), heart rate response to Valsalva or the responses to isometric exercise.
References
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Stereotaxic mapping of the monoamine pathways in the rat brain.

TL;DR: The ascending monoamine pathways in the rat brain are demonstrated by the pile up of fluorescent material occurring in the axons after various types of lesions, indicating a unique role for the locus coeruleus in influencing the activity of the entire brain.
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An autoradiographic analysis of the differential ascending projections of the dorsal and median raphe nuclei in the rat

TL;DR: The differential projections from the dorsal raphe and median raphe nuclei of the midbrain were autoradiographically traced in the rat brain after 3H‐proline micro‐injections to identify six ascending fiber tracts.
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Evidence for the existence of monoamine neurons in the central nervous system. 3. the monoamine nerve terminal.

TL;DR: All the data strongly support the view that the specific central neurons giving rise to the terminals are monoaminergic, i.e. function by releasing their amines from the synaptic terminals, Consequently, DA, NA and 5-HT seem to be central neurotransmitters.
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