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Neurophysiology and neuropharmacology of cardiovascular regulation and stress

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TLDR
The conclusion is reached that further multidisciplinary research will reveal underlying neurophysiological and neuropharmacological mechanisms responsible for stress induced cardiovascular disease and lead to new methods of treatment.
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This article is published in Neuroscience & Biobehavioral Reviews.The article was published on 1981-03-01. It has received 121 citations till now.

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How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions.

TL;DR: This review considers recent findings regarding GC action and generates criteria for determining whether a particular GC action permits, stimulates, or suppresses an ongoing stress-response or, as an additional category, is preparative for a subsequent stressor.
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Autonomic determinism: the modes of autonomic control, the doctrine of autonomic space, and the laws of autonomic constraint.

TL;DR: A formal 2-dimensional conception of autonomic space is proposed, and a quantitative model for its translation into a functional output surface is derived and has fundamental implications for the direction and interpretation of a wide array of psychophysiological studies.
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Interactions Between Cardiovascular and Pain Regulatory Systems

TL;DR: The present analysis suggests that the inhibition of pain brought about by elevations in either arterial or venous blood pressure may provide a form of psychophysiological relief under situations of stress and contribute to the development of essential hypertension in humans.
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Afferent and efferent connections of the A5 noradrenergic cell group in the rat.

TL;DR: In this article, the supraspinal afferent and efferent connections of the A5 noradrenergic cell group were examined in rats and very small deposits of HRP-WGA were made in the rostral A5 area.
References
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Journal ArticleDOI

Effect of Stress on Serotonin Concentration and Tryptophan Hydroxylase Activity of Brain Nuclei

TL;DR: A rapid release of 5-HT both from the cells and the axon terminals in the central nervous system is suggested, and failure, even with repeated stresses, to elicit induction of increased levels of the biosynthetic enzyme regulating the synthesis of the neurotransmitter is suggested.
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The trigeminal depressor response: a cardiovascular reflex originating from the trigeminal system.

TL;DR: The trigeminal depressor response (TDR) as discussed by the authors has been shown to be related to arterial baroreceptor reflexes in the brain stem of the rabbit and has been previously described from microelectrical stimulation of the spinal trigemial complex.
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Atrial receptors with nonmedullated vagal afferents in the cat. Discharge frequency and pattern in relation to atrial pressure.

Peter Thorén
- 01 May 1976 - 
TL;DR: The response of 14 atrial receptors with nonmedullated vagal afferents to changes in atrial pressure was determined in anesthetized thoracotomized cats and receptors connected to vagal C fibers are present throughout both atria and are activated by moderate changes in pressure.
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Medullary cells of origin of vagal cardioinhibitory fibers in the pigeon. II. Electrical stimulation of the dorsal motor nucleus.

TL;DR: Stimulation of the peripheral end of the cervical vagus results in marked bradycardia, a secondary fall in blood pressure, and little change in respiration.
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Elevated adrenaline content in nuclei of the medulla oblongata and the hypothalamus during the development of spontaneous hypertension

TL;DR: Investigating how the differences in the A content of the individual nuclei are related to the early development of spontaneous hypertension found that the Acontaining neurons in the medulla oblongata and in the hypothalamus might play a role in the development of genetic hypertension.
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