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Neurophysiology and neuropharmacology of cardiovascular regulation and stress

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TLDR
The conclusion is reached that further multidisciplinary research will reveal underlying neurophysiological and neuropharmacological mechanisms responsible for stress induced cardiovascular disease and lead to new methods of treatment.
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This article is published in Neuroscience & Biobehavioral Reviews.The article was published on 1981-03-01. It has received 121 citations till now.

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How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions.

TL;DR: This review considers recent findings regarding GC action and generates criteria for determining whether a particular GC action permits, stimulates, or suppresses an ongoing stress-response or, as an additional category, is preparative for a subsequent stressor.
Journal ArticleDOI

Autonomic determinism: the modes of autonomic control, the doctrine of autonomic space, and the laws of autonomic constraint.

TL;DR: A formal 2-dimensional conception of autonomic space is proposed, and a quantitative model for its translation into a functional output surface is derived and has fundamental implications for the direction and interpretation of a wide array of psychophysiological studies.
Journal ArticleDOI

Interactions Between Cardiovascular and Pain Regulatory Systems

TL;DR: The present analysis suggests that the inhibition of pain brought about by elevations in either arterial or venous blood pressure may provide a form of psychophysiological relief under situations of stress and contribute to the development of essential hypertension in humans.
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Afferent and efferent connections of the A5 noradrenergic cell group in the rat.

TL;DR: In this article, the supraspinal afferent and efferent connections of the A5 noradrenergic cell group were examined in rats and very small deposits of HRP-WGA were made in the rostral A5 area.
References
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Arterial Baroreceptor Fibers from the Aortic Region of the Dog in the Cervical Vagus Nerve

TL;DR: The neural pathways followed by sensory fibers from arterial baroreceptors in the aortic region of the dog were investigated with neurophysiological recording and subjective evidence for the presence of systemic arterialbaroreceptor fibers was obtained.
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Neurons in medullary areas controlling ACTH: atrial input and rostral projections.

TL;DR: The results suggest that pathways displaying rate sensitivity project from the right atrium via B-receptors to the DRP, and are driven antidromically from the locus subcoeruleus and lateral ventral tegmental nucleus and in anterolateral NI.
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Failure of beta-adrenergic receptor blockade to prevent arrhythmias induced by sympathetic nerve stimulation.

TL;DR: The results suggest that the adrenergic neuroeffector junction is fundamentally different from any hitherto described, differing perhaps in the neurotransmitter involved or in the nature of the receptor.
Journal Article

Centrally-mediated cardiovascular effects of 5-hydroxytryptophan in MAO-inhibited dogs: modification by autonomic antagonists.

TL;DR: Results indicate that cerebral decarboxylation and formation of 5-HT are responsible for the hypotension after 5- HTP in MAO inhibited dogs.
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