Journal ArticleDOI
NK cell activation by dendritic cells (DCs) requires the formation of a synapse leading to IL-12 polarization in DCs
Christophe Borg,Abdelali Jalil,Diego Laderach,Kouji Maruyama,Hiro Wakasugi,Sabine Charrier,Bernhard Ryffel,Alessandra Cambi,Carl G. Figdor,William Vainchenker,Anne Galy,Anne Caignard,Laurence Zitvogel +12 more
TLDR
The cross-talk between DCs and NK cells is dictated by functional synapses, and the synaptic delivery of IL-12 by DCs was required for IFN-gamma secretion by NK cells, as assessed using inhibitors of cytoskeleton rearrangements and transwell experiments.About:
This article is published in Blood.The article was published on 2004-11-15. It has received 331 citations till now. The article focuses on the topics: Lymphokine-activated killer cell & Interleukin 21.read more
Citations
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Journal ArticleDOI
Natural-killer cells and dendritic cells: “l'union fait la force”
Thierry Walzer,Marc Dalod,Marc Dalod,Scott H. Robbins,Scott H. Robbins,Laurence Zitvogel,Laurence Zitvogel,Eric Vivier,Eric Vivier +8 more
TL;DR: DCs and NK cells are equipped with complementary sets of receptors that allow the recognition of various pathogenic agents, emphasizing the role of NK-cell/DC crosstalk in the coordination of innate and adaptive immune responses.
Journal ArticleDOI
Close encounters of different kinds: Dendritic cells and NK cells take centre stage
TL;DR: Dendritic cells, long recognized as key initiators of primary adaptive immunity, are now also seen as crucial regulators of aspects of innate immunity, in particular natural-killer-cell function.
Journal ArticleDOI
Formation and function of the lytic NK-cell immunological synapse
TL;DR: The natural killer (NK)-cell immunological synapse is the dynamic interface formed between an NK cell and its target cell and this tight regulation underlies the precision with which NK cells select and kill susceptible target cells.
Journal ArticleDOI
Transforming growth factor-beta controls T helper type 1 cell development through regulation of natural killer cell interferon-gamma.
Yasmina Laouar,Fayyaz S. Sutterwala,Leonid Gorelik,Leonid Gorelik,Richard A. Flavell,Richard A. Flavell +5 more
TL;DR: It is shown that transforming growth factor-β (TGF-β) controlled TH1 differentiation through the regulation of interferon-γ produced by natural killer (NK) cells, indicating a previously undescribed demarcation of the function of TGF- β in NK cells versus dendritic cells.
Journal ArticleDOI
NK-dependent DC maturation is mediated by TNFα and IFNγ released upon engagement of the NKp30 triggering receptor
Massimo Vitale,Mariella Della Chiesa,Simona Carlomagno,Daniela Pende,Maurizio Aricò,Lorenzo Moretta,Alessandro Moretta +6 more
TL;DR: It is shown that also the NK-mediated induction of DC maturation is dependent on NKp30, and the ability to promote maturation was essentially confined to NK cells expressing the killer immunoglobulin-like receptor–negative (KIR–) NKG2Adull phenotype.
References
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Journal ArticleDOI
Functional rafts in cell membranes
Kai Simons,Elina Ikonen +1 more
TL;DR: A new aspect of cell membrane structure is presented, based on the dynamic clustering of sphingolipids and cholesterol to form rafts that move within the fluid bilayer that function as platforms for the attachment of proteins when membranes are moved around inside the cell and during signal transduction.
Journal ArticleDOI
Effectiveness of Donor Natural Killer Cell Alloreactivity in Mismatched Hematopoietic Transplants
Loredana Ruggeri,Marusca Capanni,Elena Urbani,Katia Perruccio,Warren D. Shlomchik,Antonella Tosti,Sabrina Posati,Daniela Rogaia,Francesco Frassoni,Franco Aversa,Massimo F. Martelli,Andrea Velardi +11 more
TL;DR: It is shown that donor-versus-recipient natural killer (NK)–cell alloreactivity could eliminate leukemia relapse and graft rejection and protect patients against GVHD in human transplants and in mice, the pretransplant infusion of alloreactive NK cells obviated the need for high-intensity conditioning and reduced GV HD.
Journal ArticleDOI
The Immunological Synapse: A Molecular Machine Controlling T Cell Activation
Arash Grakoui,Shannon K. Bromley,Cenk Sumen,Mark M. Davis,Andrey S. Shaw,Paul M. Allen,Michael L. Dustin +6 more
TL;DR: Immunological synapse formation is now shown to be an active and dynamic mechanism that allows T cells to distinguish potential antigenic ligands and was a determinative event for T cell proliferation.
Book ChapterDOI
Biology of natural killer cells.
TL;DR: The existence of NK cells has prompted a reinterpretation of both the studies of specific cytotoxicity against spontaneous human tumors and the theory of immune surveillance, at least in its most restrictive interpretation.
Journal ArticleDOI
Functions of lipid rafts in biological membranes.
Deborah A. Brown,Erwin London +1 more
TL;DR: The relationship between detergent-resistant membranes, rafts, caveolae, and low-density plasma membrane fragments, and possible functions of lipid rafts in membranes are discussed.