Journal ArticleDOI
Non-transferrin bound iron: a key role in iron overload and iron toxicity.
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TLDR
Plasma NTBI and especially labile plasma iron determinations represent a new important biological tool since elimination of this toxic iron species is a major therapeutic goal.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 2012-03-01. It has received 533 citations till now. The article focuses on the topics: Transferrin & Transferrin saturation.read more
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Systemic iron homeostasis
TL;DR: This review summarizes and discusses recent progress in molecular characterization of systemic iron homeostasis and its disorders, and identifies areas for further investigation.
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Iron Overload in Human Disease
Robert E. Fleming,Prem Ponka +1 more
TL;DR: How the body absorbs, uses, and loses iron is reviewed and both common and unusual causes of iron overload and treatment of the resulting disorders are explored.
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Mechanisms of mammalian iron homeostasis
TL;DR: This review outlines recent advances in iron regulatory pathways as well as in mechanisms underlying intracellular iron trafficking, an important but less studied area of mammalian iron homeostasis.
Guidelines for the Management of Transfusion Dependent Thalassaemia (TDT)
TL;DR: The third edition of the TIF guidelines was published by Musallam et al. as mentioned in this paper and includes updated information on new approaches for more effective, safe and less laborious treatment, and an overview of the progress achieved to date towards a total cure using methods such as gene therapy and stem cell transplantation.
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Iron neurochemistry in Alzheimer's disease and Parkinson's disease: targets for therapeutics
Abdel A. Belaidi,Ashley I. Bush +1 more
TL;DR: The current knowledge on iron homeostasis in the brain is discussed and how alterations in brain iron metabolism affect neuronal function with emphasis on iron dysregulation in Alzheimer′s and Parkinson′s diseases is explored.
References
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Journal ArticleDOI
Cloning and characterization of a mammalian proton-coupled metal-ion transporter
Hiromi Gunshin,Bryan Mackenzie,Urs V. Berger,Yoshimi Gunshin,Michael F. Romero,Walter F. Boron,Stephan Nussberger,John L. Gollan,Matthias A. Hediger +8 more
TL;DR: A new metal-ion transporter in the rat, DCT1, which has an unusually broad substrate range that includes Fe2+, Zn2+, Mn2+, Co2+, Cd2+, Cu2+, Ni2+ and Pb2+.
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Advances in metal-induced oxidative stress and human disease
Klaudia Jomová,Marian Valko +1 more
TL;DR: An overview of redox and non-redox metal-induced formation of free radicals and the role of oxidative stress in toxic action of metals is provided.
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Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter
Adriana Donovan,Alison Brownlie,Alison Brownlie,Yi Zhou,Jennifer L. Shepard,Stephen J. Pratt,John Moynihan,Barry H. Paw,Anna Drejer,Bruce A. Barut,Bruce A. Barut,Agustín G. Zapata,Terence C. Law,Carlo Brugnara,Samuel E. Lux,Geraldine S. Pinkus,Jack L. Pinkus,Paul D. Kingsley,James Palis,Mark D. Fleming,Mark D. Fleming,Nancy C. Andrews,Nancy C. Andrews,Leonard I. Zon,Leonard I. Zon +24 more
TL;DR: The gene responsible for the hypochromic anaemia of the zebrafish mutant weissherbst is identified and Ferroportin1 function may be perturbed in mammalian disorders of iron deficiency or overload.
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A Novel Duodenal Iron-Regulated Transporter, IREG1, Implicated in the Basolateral Transfer of Iron to the Circulation
Andrew T. McKie,Paola Marciani,Andreas Rolfs,Karen Brennan,Kristina Wehr,Dalna Barrow,Silvia Miret,Adrian Bomford,Tim J Peters,Farzin Farzaneh,Matthias A. Hediger,Matthias W. Hentze,Robert J. Simpson +12 more
TL;DR: The isolation and characterization of a novel cDNA (Ireg1) encoding a duodenal protein that is localized to the basolateral membrane of polarized epithelial cells are described and it is concluded that IREG1 represents the long-sought duodental iron export protein and is upregulated in the iron overload disease, hereditary hemochromatosis.
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A Novel Mammalian Iron-regulated Protein Involved in Intracellular Iron Metabolism
Sherry L. Abboud,David J. Haile +1 more
TL;DR: Data indicate that MTP1 is an iron-regulated membrane-spanning protein that is involved in intracellular iron metabolism.