Journal ArticleDOI
Notch Signaling: Cell Fate Control and Signal Integration in Development
TLDR
Notch signaling defines an evolutionarily ancient cell interaction mechanism, which plays a fundamental role in metazoan development, providing a general developmental tool to influence organ formation and morphogenesis.Abstract:
Notch signaling defines an evolutionarily ancient cell interaction mechanism, which plays a fundamental role in metazoan development. Signals exchanged between neighboring cells through the Notch receptor can amplify and consolidate molecular differences, which eventually dictate cell fates. Thus, Notch signals control how cells respond to intrinsic or extrinsic developmental cues that are necessary to unfold specific developmental programs. Notch activity affects the implementation of differentiation, proliferation, and apoptotic programs, providing a general developmental tool to influence organ formation and morphogenesis.read more
Citations
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Alzheimer's Disease: Genes, Proteins, and Therapy
TL;DR: Evidence that the presenilin proteins, mutations in which cause the most aggressive form of inherited AD, lead to altered intramembranous cleavage of the beta-amyloid precursor protein by the protease called gamma-secretase has spurred progress toward novel therapeutics and provided discrete biochemical targets for drug screening and development.
Journal ArticleDOI
Signaling--2000 and beyond.
TL;DR: The important findings in the history of signal transduction are adequately covered in many reviews, and I have therefore cited reviews that discuss the seminal papers.
Journal ArticleDOI
Notch signalling: a simple pathway becomes complex
TL;DR: Although the intracellular transduction of the Notch signal is remarkably simple, with no secondary messengers, this pathway functions in an enormous diversity of developmental processes and its dysfunction is implicated in many cancers.
Journal ArticleDOI
Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse
Sunil R. Hingorani,Emanuel F. Petricoin,Anirban Maitra,Vinodh N. Rajapakse,Catrina King,Michael A. Jacobetz,Sally Ross,Thomas P. Conrads,Timothy D. Veenstra,Ben A. Hitt,Yoshiya Kawaguchi,Donald J. Johann,Lance A. Liotta,Howard C. Crawford,Mary E. Putt,Tyler Jacks,Christopher V.E. Wright,Ralph H. Hruban,Andrew M. Lowy,David A. Tuveson +19 more
TL;DR: It is found that physiological levels of Kras(G12D) induce ductal lesions that recapitulate the full spectrum of human pancreatic intraepithelial neoplasias (PanINs), putative precursors to invasive pancreatic cancer.
Journal ArticleDOI
Out of Eden: Stem Cells and Their Niches
Fiona M. Watt,Brigid L.M. Hogan +1 more
TL;DR: Both intrinsic and extrinsic signals regulate stem cell fate and some of these signals have now been identified and can be exploited in the application of stem cells to tissue replacement therapy.
References
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Journal ArticleDOI
A dorsal/ventral boundary established by Notch controls growth and polarity in the Drosophila eye
Maria Dominguez,Jose F. de Celis +1 more
TL;DR: It is suggested that boundaries of fringe expression and Notch activation constitute a general mechanism that directs growth and patterning of large fields of cells during Drosophila wing formation and vertebrate somitogenesis.
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Organization of wing formation and induction of a wing-patterning gene at the dorsal/ventral compartment boundary
TL;DR: The dorsal/ventral boundary is shown to organize wing formation and vestigial gene expression in Drosophila, and interactions between dorsal and ventral cells in the growing imaginal disc induce vestigIAL gene expression through a discrete, extraordinarily conserved imaginal Disc-specific enhancer.
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The function of the neurogenic genes during epithelial development in the Drosophila embryo.
TL;DR: The complex embryonic phenotype of the six neurogenic mutations Notch, mastermind, big brain, Delta, Enhancer of split and neuralized was analyzed by using different antibodies and PlacZ markers, which allowed us to label most of the known embryonic tissues.
Journal ArticleDOI
Asymmetric Notch activation specifies photoreceptors R3 and R4 and planar polarity in the Drosophila eye.
Manolis Fanto,Marek Mlodzik +1 more
TL;DR: Notch and Delta (Dl) are identified as dominant enhancers of the phenotypes produced by overexpression of fz and dishevelled (dsh), which encodes a signalling component downstream of Fz, and it is shown that Dl-mediated activation of Notch is required for establishment of ommatidial polarity.
Journal ArticleDOI
Ligand-induced cleavage and regulation of nuclear entry of Notch in Drosophila melanogaster embryos
TL;DR: In Drosophila melanogaster, Notch (N) is processed in a ligand-dependent fashion to generate phosphorylated, soluble intracellular derivatives and one function of soluble forms of N is to bind to Su(H), and in the nucleus to act directly as a transcriptional transactivator of the latter protein.