Journal ArticleDOI
Notch Signaling: Cell Fate Control and Signal Integration in Development
TLDR
Notch signaling defines an evolutionarily ancient cell interaction mechanism, which plays a fundamental role in metazoan development, providing a general developmental tool to influence organ formation and morphogenesis.Abstract:
Notch signaling defines an evolutionarily ancient cell interaction mechanism, which plays a fundamental role in metazoan development. Signals exchanged between neighboring cells through the Notch receptor can amplify and consolidate molecular differences, which eventually dictate cell fates. Thus, Notch signals control how cells respond to intrinsic or extrinsic developmental cues that are necessary to unfold specific developmental programs. Notch activity affects the implementation of differentiation, proliferation, and apoptotic programs, providing a general developmental tool to influence organ formation and morphogenesis.read more
Citations
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Journal ArticleDOI
A notch-independent activity of suppressor of hairless is required for normal mechanoreceptor physiology.
Scott Barolo,Richard G Walker,Andrey Polyanovsky,Gina Freschi,Thomas A. Keil,James W. Posakony +5 more
TL;DR: It is shown that Su(H) has three distinct functions in the development of external mechanosensory organs in Drosophila: Notch-dependent transcriptional activation and a novel auto-repression function, both of which direct cell fate decisions, and a Novel auto-activation function required for normal socket cell differentiation.
Journal ArticleDOI
Inhibition of NOTCH signaling by gamma secretase inhibitor engages the RB pathway and elicits cell cycle exit in T-cell acute lymphoblastic leukemia cells.
Sudhir Rao,Jennifer O'Neil,Cole Liberator,James S. Hardwick,Xudong Dai,Theresa Zhang,Edyta Tyminski,Jing Yuan,Nancy E. Kohl,Victoria M. Richon,Lex H.T. Van der Ploeg,Pamela Carroll,Giulio Draetta,A. Thomas Look,A. Thomas Look,Peter Strack,Christopher Winter,Christopher Winter +17 more
TL;DR: Investigation of the mechanisms of GSI sensitivity across a panel of T-ALL cell lines yielded an approach for patient stratification based on pathway activity and a rational combination strategy for enhanced response to GSI, providing evidence that GSI engagement of the CDK4/RB pathway is an important mechanism of G SI action.
Journal ArticleDOI
Notch signaling in mammary gland tumorigenesis.
Robert Callahan,Ahmed Raafat +1 more
TL;DR: The structure and function of the Notch receptor, as well as the components that comprise and modify the signaling pathway, are summarized and the potential role of Notch in mammary gland development and tumorigenesis is discussed.
Journal ArticleDOI
Notch and the Skeleton
TL;DR: Dysregulation of Notch signaling is the underlying cause of diseases affecting the skeletal tissue, including Alagille syndrome, spondylocostal dysostosis, and possibly, osteosarcoma.
Journal ArticleDOI
Role of conserved intracellular motifs in Serrate signalling, cis-inhibition and endocytosis.
TL;DR: Two conserved motifs in the intracellular domain of Serrate are identified that are required for efficient endocytosis and are shown to be dileucine and novel motifs that are necessary for interactions with Mindbomb1/Neuralized and is strictly required for Serrate to trans‐activate and internalise efficiently.
References
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Journal ArticleDOI
Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia
Anne Joutel,Christophe Corpechot,Anne Ducros,Katayoun Vahedi,Hugues Chabriat,Philippe Mouton,Sonia Alamowitch,Valérie Domenga,Michaelle Cécillion,Emmanuelle Maréchal,Jacqueline Maciazek,Céline Vayssière,Corinne Cruaud,E. A. Cabanis,Marie Madeleine Ruchoux,Jean Weissenbach,Jean Francois Bach,Marie-Germaine Bousser,Elisabeth Tournier-Lasserve +18 more
TL;DR: The characterization of the human Notch3 gene, which was previously mapped to the CADASIL critical region, is reported, indicating that Notch 3 could be the defective protein in CADASil patients.
Journal ArticleDOI
Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain.
TL;DR: It is shown that signalling by a constitutively active membrane-bound Notch-1 protein requires the proteolytic release of the Notch intracellular domain (NICD), which interacts preferentially with CSL.
Journal ArticleDOI
Signalling downstream of activated mammalian Notch.
Sophie Jarriault,Christel Brou,Frédérique Logeat,Eric H. Schroeter,Raphael Kopan,Alain Israël +5 more
TL;DR: It is shown that activated forms of mNotch associate with the human analogue of Su(H), KBF2/RBP-JK and act as transcriptional activators through theKBF2-binding sites of the HES-1 promoter and block MyoD-induced myogenesis5-7.
Journal Article
Notch signaling : Signal transduction
TL;DR: The Notch/Lin-12/Glp-1 receptor family mediates the specification of numerous cell fates during development in Drosophila and Caenorhabditis elegans and putative components of the signaling cascade are identified, including a conserved family of extracellular ligands and two cellular factors that may associate with the Notch Intracellular domain.
Journal ArticleDOI
Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1
Linheng Li,Ian D. Krantz,Yu Deng,Yu Deng,Anna Genin,Amy B. Banta,Colin Collins,Ming Qi,Barbara J. Trask,Wen Lin Kuo,Joanne Cochran,Teresa Costa,Mary Ella M Pierpont,Elizabeth B. Rand,David A. Piccoli,Leroy Hood,Nancy B. Spinner +16 more
TL;DR: Four distinct coding mutations in JAG1 are demonstrated, providing evidence that it is the causal gene for Alagille syndrome, and supporting the hypothesis that haploinsufficiency for this gene is one of the mechanisms causing the Alagile syndrome phenotype.