Journal ArticleDOI
Notch Signaling: Cell Fate Control and Signal Integration in Development
TLDR
Notch signaling defines an evolutionarily ancient cell interaction mechanism, which plays a fundamental role in metazoan development, providing a general developmental tool to influence organ formation and morphogenesis.Abstract:
Notch signaling defines an evolutionarily ancient cell interaction mechanism, which plays a fundamental role in metazoan development. Signals exchanged between neighboring cells through the Notch receptor can amplify and consolidate molecular differences, which eventually dictate cell fates. Thus, Notch signals control how cells respond to intrinsic or extrinsic developmental cues that are necessary to unfold specific developmental programs. Notch activity affects the implementation of differentiation, proliferation, and apoptotic programs, providing a general developmental tool to influence organ formation and morphogenesis.read more
Citations
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Journal ArticleDOI
RBPjκ-dependent Notch signaling regulates mesenchymal progenitor cell proliferation and differentiation during skeletal development
Yufeng Dong,Alana M. Jesse,Anat Kohn,Lea M. Gunnell,Tasuku Honjo,Michael J. Zuscik,Regis J. O'Keefe,Matthew J. Hilton +7 more
TL;DR: Data demonstrate for the first time that the RBPjκ-dependent Notch signaling pathway is a crucial regulator ofMPC proliferation and differentiation during skeletal development and implicates the Notch pathway as a general suppressor of MPC differentiation that does not bias lineage allocation.
Journal ArticleDOI
Control of arterial branching morphogenesis in embryogenesis: go with the flow.
TL;DR: It is suggested that flow-evoked remodeling processes determine the number of preexisting collaterals during critical periods of embryo-fetal development, and that hemodynamics plays a pivotal role in shaping the arterial system.
Journal ArticleDOI
The Ras/MAPK cascade and the control of positive selection
TL;DR: This review examines the factors that connect the TCR to the Ras/Erk cascade in DP thymocytes, as well as what the authors know about the downstream effectors of the Ras or Erk cascade important for positive selection, and considers the possible role of this cascade in CD4/CD8 lineage development.
Journal ArticleDOI
Oxygen Concentration Determines the Biological Effects of NOTCH-1 Signaling in Adenocarcinoma of the Lung
Yuanbin Chen,Melissa A. De Marco,Irene Graziani,Adi F. Gazdar,Peter Strack,Lucio Miele,Maurizio Bocchetta +6 more
TL;DR: The role of NOTCH in lung cancer and as a therapeutic target for the treatment of lung and other hypoxic tumor types is strengthened and hypoxia dramatically elevates NOTCH signaling in lung tumor cell lines and concomitantly sensitizes them to inhibition via small-molecule gamma-secretase inhibitors or NOTCH-1 RNA interference.
Journal ArticleDOI
Notch pathway activation targets AML-initiating cell homeostasis and differentiation
Camille Lobry,Panagiotis Ntziachristos,Delphine Ndiaye-Lobry,Philmo Oh,Luisa Cimmino,Nan Zhu,Elisa Araldi,Wenhuo Hu,Jacquelyn Freund,Omar Abdel-Wahab,Sherif Ibrahim,Dimitris Skokos,Scott A. Armstrong,Ross L. Levine,Christopher Y. Park,Iannis Aifantis +15 more
TL;DR: Notch behaves as a tumor suppressor in AML, and Notch activation induces cell cycle arrest, differentiation, and apoptosis of AML-initiating cells.
References
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Journal ArticleDOI
Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia
Anne Joutel,Christophe Corpechot,Anne Ducros,Katayoun Vahedi,Hugues Chabriat,Philippe Mouton,Sonia Alamowitch,Valérie Domenga,Michaelle Cécillion,Emmanuelle Maréchal,Jacqueline Maciazek,Céline Vayssière,Corinne Cruaud,E. A. Cabanis,Marie Madeleine Ruchoux,Jean Weissenbach,Jean Francois Bach,Marie-Germaine Bousser,Elisabeth Tournier-Lasserve +18 more
TL;DR: The characterization of the human Notch3 gene, which was previously mapped to the CADASIL critical region, is reported, indicating that Notch 3 could be the defective protein in CADASil patients.
Journal ArticleDOI
Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain.
TL;DR: It is shown that signalling by a constitutively active membrane-bound Notch-1 protein requires the proteolytic release of the Notch intracellular domain (NICD), which interacts preferentially with CSL.
Journal ArticleDOI
Signalling downstream of activated mammalian Notch.
Sophie Jarriault,Christel Brou,Frédérique Logeat,Eric H. Schroeter,Raphael Kopan,Alain Israël +5 more
TL;DR: It is shown that activated forms of mNotch associate with the human analogue of Su(H), KBF2/RBP-JK and act as transcriptional activators through theKBF2-binding sites of the HES-1 promoter and block MyoD-induced myogenesis5-7.
Journal Article
Notch signaling : Signal transduction
TL;DR: The Notch/Lin-12/Glp-1 receptor family mediates the specification of numerous cell fates during development in Drosophila and Caenorhabditis elegans and putative components of the signaling cascade are identified, including a conserved family of extracellular ligands and two cellular factors that may associate with the Notch Intracellular domain.
Journal ArticleDOI
Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1
Linheng Li,Ian D. Krantz,Yu Deng,Yu Deng,Anna Genin,Amy B. Banta,Colin Collins,Ming Qi,Barbara J. Trask,Wen Lin Kuo,Joanne Cochran,Teresa Costa,Mary Ella M Pierpont,Elizabeth B. Rand,David A. Piccoli,Leroy Hood,Nancy B. Spinner +16 more
TL;DR: Four distinct coding mutations in JAG1 are demonstrated, providing evidence that it is the causal gene for Alagille syndrome, and supporting the hypothesis that haploinsufficiency for this gene is one of the mechanisms causing the Alagile syndrome phenotype.