Journal ArticleDOI
Notch Signaling: Cell Fate Control and Signal Integration in Development
TLDR
Notch signaling defines an evolutionarily ancient cell interaction mechanism, which plays a fundamental role in metazoan development, providing a general developmental tool to influence organ formation and morphogenesis.Abstract:
Notch signaling defines an evolutionarily ancient cell interaction mechanism, which plays a fundamental role in metazoan development. Signals exchanged between neighboring cells through the Notch receptor can amplify and consolidate molecular differences, which eventually dictate cell fates. Thus, Notch signals control how cells respond to intrinsic or extrinsic developmental cues that are necessary to unfold specific developmental programs. Notch activity affects the implementation of differentiation, proliferation, and apoptotic programs, providing a general developmental tool to influence organ formation and morphogenesis.read more
Citations
More filters
Journal ArticleDOI
Alzheimer's Disease: Genes, Proteins, and Therapy
TL;DR: Evidence that the presenilin proteins, mutations in which cause the most aggressive form of inherited AD, lead to altered intramembranous cleavage of the beta-amyloid precursor protein by the protease called gamma-secretase has spurred progress toward novel therapeutics and provided discrete biochemical targets for drug screening and development.
Journal ArticleDOI
Signaling--2000 and beyond.
TL;DR: The important findings in the history of signal transduction are adequately covered in many reviews, and I have therefore cited reviews that discuss the seminal papers.
Journal ArticleDOI
Notch signalling: a simple pathway becomes complex
TL;DR: Although the intracellular transduction of the Notch signal is remarkably simple, with no secondary messengers, this pathway functions in an enormous diversity of developmental processes and its dysfunction is implicated in many cancers.
Journal ArticleDOI
Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse
Sunil R. Hingorani,Emanuel F. Petricoin,Anirban Maitra,Vinodh N. Rajapakse,Catrina King,Michael A. Jacobetz,Sally Ross,Thomas P. Conrads,Timothy D. Veenstra,Ben A. Hitt,Yoshiya Kawaguchi,Donald J. Johann,Lance A. Liotta,Howard C. Crawford,Mary E. Putt,Tyler Jacks,Christopher V.E. Wright,Ralph H. Hruban,Andrew M. Lowy,David A. Tuveson +19 more
TL;DR: It is found that physiological levels of Kras(G12D) induce ductal lesions that recapitulate the full spectrum of human pancreatic intraepithelial neoplasias (PanINs), putative precursors to invasive pancreatic cancer.
Journal ArticleDOI
Out of Eden: Stem Cells and Their Niches
Fiona M. Watt,Brigid L.M. Hogan +1 more
TL;DR: Both intrinsic and extrinsic signals regulate stem cell fate and some of these signals have now been identified and can be exploited in the application of stem cells to tissue replacement therapy.
References
More filters
Journal ArticleDOI
Antineurogenic phenotypes induced by truncated Notch proteins indicate a role in signal transduction and may point to a novel function for Notch in nuclei.
TL;DR: The activities of the dominant, gain-of-function proteins indicate that Notch functions as a signal transducing receptor during ectoderm development and production of antineurogenic Notch proteins in embryos deficient for the other neurogenic genes allowed functional dependencies to be established.
Journal ArticleDOI
Alterations in Notch signaling in neoplastic lesions of the human cervix
Panayiotis Zagouras,Stefano Stifani,Christine Marie Blaumueller,Maria Luisa Carcangiu,Spyros Artavanis-Tsakonas +4 more
TL;DR: The evidence suggests that Notch expression is associated with cell populations that are undergoing cell fate changes and that notch activity can be used to monitor cell fate abnormalities in cervical as well as other epithelial neoplasias.
Journal ArticleDOI
Notch signaling inhibits muscle cell differentiation through a CBF1-independent pathway
Carrie J. Shawber,Donna Nofziger,James J. Hsieh,Claire E. Lindsell,Oliver Bogler,Diane Hayward,Gerry Weinmaster +6 more
TL;DR: It is proposed that Notch signaling activates at least two different pathways: one which involves CBF1 as an intermediate and one which does not, and Jagged-Notch interactions that prevent the expression of muscle cell specific genes do not involve the upregulation of endogenous HES-1.
Journal ArticleDOI
Serrate signals through Notch to establish a Wingless-dependent organizer at the dorsal/ventral compartment boundary of the Drosophila wing
TL;DR: It is reported here that Serrate and Notch mediate the interaction between dorsal and ventral cells to direct localized expression of Wingless at the D/V boundary.
Journal ArticleDOI
Correlating Notch Signaling with Thymocyte Maturation
TL;DR: The constitutively active intracellular fragment of murine Notch-1 is identified as capable of rendering thymomas resistant to glucocorticoid-induced apoptosis, and activation of the Notch signaling pathway upregulated a number of other markers that correlate with DP maturation into both the CD4 and CD8 lineages.