Journal ArticleDOI
Notch Signaling: Cell Fate Control and Signal Integration in Development
TLDR
Notch signaling defines an evolutionarily ancient cell interaction mechanism, which plays a fundamental role in metazoan development, providing a general developmental tool to influence organ formation and morphogenesis.Abstract:
Notch signaling defines an evolutionarily ancient cell interaction mechanism, which plays a fundamental role in metazoan development. Signals exchanged between neighboring cells through the Notch receptor can amplify and consolidate molecular differences, which eventually dictate cell fates. Thus, Notch signals control how cells respond to intrinsic or extrinsic developmental cues that are necessary to unfold specific developmental programs. Notch activity affects the implementation of differentiation, proliferation, and apoptotic programs, providing a general developmental tool to influence organ formation and morphogenesis.read more
Citations
More filters
Journal ArticleDOI
Notch 1 signaling regulates peripheral T cell activation
TL;DR: Notch 1 signaling may play an important role in regulating naive T cell activation and homeostasis through inhibition of AKT and GSK3beta phosphorylation following Notch 1 engagement.
Journal ArticleDOI
Cellular commitment in the developing cerebellum
Hassan Marzban,Marc R. Del Bigio,Javad Alizadeh,Saeid Ghavami,Robby M. Zachariah,Mojgan Rastegar +5 more
TL;DR: The anatomical structure of human and mouse cerebellum, the cellular composition of developing cerebellums, and the underlying gene expression programs involved in cell fate commitments in the cerebellar development are highlighted.
Journal ArticleDOI
Neuralized functions as an E3 ubiquitin ligase during Drosophila development.
Edward Yeh,Edward Yeh,Matt Dermer,Cosimo Commisso,Lily Zhou,C.Jane McGlade,Gabrielle L. Boulianne,Gabrielle L. Boulianne +7 more
TL;DR: It is shown that Neu is required at the plasma membrane for functional activity and that its RING finger domain acts as an E3 ubiquitin ligase, suggesting that the role of NeU is to target components of the N-Dl pathway for ubiquitination, allowing for propagation and/or regulation of the signal.
Journal ArticleDOI
Notch signaling: its role in epidermal homeostasis and in the pathogenesis of skin diseases.
TL;DR: Notch activation results in the promotion of growth arrest and the onset of differentiation, therefore suggesting that specific Notch activation may regulate skin homeostasis by balancing these processes, i.e. limiting the occurrence of psoriasis and skin cancers.
Journal ArticleDOI
The Association of Notch2 and NF-κB Accelerates RANKL-Induced Osteoclastogenesis
Hidefumi Fukushima,Hidefumi Fukushima,Akihiro Nakao,Fujio Okamoto,Masashi Shin,Hiroshi Kajiya,Seiji Sakano,Anna Bigas,Eijiro Jimi,Koji Okabe +9 more
TL;DR: It is shown that RANKL induces expression of Jagged1 and Notch2 in bone marrow macrophages during osteoclast differentiation and that both proteins are recruited to the NFATc1 promoter, driving its expression.
References
More filters
Journal ArticleDOI
Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia
Anne Joutel,Christophe Corpechot,Anne Ducros,Katayoun Vahedi,Hugues Chabriat,Philippe Mouton,Sonia Alamowitch,Valérie Domenga,Michaelle Cécillion,Emmanuelle Maréchal,Jacqueline Maciazek,Céline Vayssière,Corinne Cruaud,E. A. Cabanis,Marie Madeleine Ruchoux,Jean Weissenbach,Jean Francois Bach,Marie-Germaine Bousser,Elisabeth Tournier-Lasserve +18 more
TL;DR: The characterization of the human Notch3 gene, which was previously mapped to the CADASIL critical region, is reported, indicating that Notch 3 could be the defective protein in CADASil patients.
Journal ArticleDOI
Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain.
TL;DR: It is shown that signalling by a constitutively active membrane-bound Notch-1 protein requires the proteolytic release of the Notch intracellular domain (NICD), which interacts preferentially with CSL.
Journal ArticleDOI
Signalling downstream of activated mammalian Notch.
Sophie Jarriault,Christel Brou,Frédérique Logeat,Eric H. Schroeter,Raphael Kopan,Alain Israël +5 more
TL;DR: It is shown that activated forms of mNotch associate with the human analogue of Su(H), KBF2/RBP-JK and act as transcriptional activators through theKBF2-binding sites of the HES-1 promoter and block MyoD-induced myogenesis5-7.
Journal Article
Notch signaling : Signal transduction
TL;DR: The Notch/Lin-12/Glp-1 receptor family mediates the specification of numerous cell fates during development in Drosophila and Caenorhabditis elegans and putative components of the signaling cascade are identified, including a conserved family of extracellular ligands and two cellular factors that may associate with the Notch Intracellular domain.
Journal ArticleDOI
Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1
Linheng Li,Ian D. Krantz,Yu Deng,Yu Deng,Anna Genin,Amy B. Banta,Colin Collins,Ming Qi,Barbara J. Trask,Wen Lin Kuo,Joanne Cochran,Teresa Costa,Mary Ella M Pierpont,Elizabeth B. Rand,David A. Piccoli,Leroy Hood,Nancy B. Spinner +16 more
TL;DR: Four distinct coding mutations in JAG1 are demonstrated, providing evidence that it is the causal gene for Alagille syndrome, and supporting the hypothesis that haploinsufficiency for this gene is one of the mechanisms causing the Alagile syndrome phenotype.