Journal ArticleDOI
Novel molecular profiles of endometrial cancer-new light through old windows.
Andreas Doll,Miguel Abal,Marina Rigau,Marta Monge,M. Gonzalez,Santiago Demajo,Eva Colas,Marta Llauradó,H. Alazzouzi,J. Planagumá,M.A. Lohmann,J. Garcia,S. Castellvi,J. Ramon y Cajal,Antonio Gil-Moreno,Jordi Xercavins,F. Alameda,J. Reventós +17 more
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TLDR
Despite the great effort made to establish a molecularly-based histological classification, the following issues must still be clarified: what triggers the tumor cells to invade the myometrium and what causes vascular or lymphatic dissemination, finally culminating in metastasis?About:
This article is published in The Journal of Steroid Biochemistry and Molecular Biology.The article was published on 2008-02-01. It has received 213 citations till now. The article focuses on the topics: Endometrial intraepithelial neoplasia & Endometrial cancer.read more
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The molecular biology of endometrial cancers and the implications for pathogenesis, classification, and targeted therapies
TL;DR: The molecular basis for genesis of endometrioid endometrial cancer with regard to pathogenesis, classification, and implications for targeted therapies is reviewed.
Journal ArticleDOI
Factors associated with Type I and Type II endometrial cancer.
Ashley S. Felix,Joel L. Weissfeld,Roslyn A. Stone,Robert Bowser,Mamatha Chivukula,Robert P. Edwards,Faina Linkov +6 more
TL;DR: In this large retrospective cohort of patients with EC, the striking difference in risk factors associated with Type II vs. Type I tumors suggests that these subtypes represent different disease entities that require different treatment modalities.
Journal ArticleDOI
The microbiome and gynaecological cancer development, prevention and therapy
TL;DR: How dysbiosis could lead to malignancy and how cancer and its treatment can, in turn, affect the FRT microbiome are discussed, and how modulation of the microbiome might prove useful in improving responsiveness to cancer treatment and quality of life in women with gynaecological cancers are considered.
Journal ArticleDOI
Differential trends in the rising incidence of endometrial cancer by type: data from a UK population-based registry from 1994 to 2006
TL;DR: Increased incidence in endometrial cancer is confined to type 1 cancers, seen most in the 60–79 age groups and across all socioeconomic quintiles, andUrgent research is needed to investigate prevention strategies in type 1 and improve therapy in type 2 cancers.
Journal ArticleDOI
Should grade 3 endometrioid endometrial carcinoma be considered a type 2 cancer-a clinical and pathological evaluation.
Martin A. Voss,Raji Ganesan,Linmarie Ludeman,Keith McCarthy,R Gornall,Gerhard Schaller,Wenbin Wei,Sudha Sundar +7 more
TL;DR: G3 EEC is better characterised as type 2 cancer and should be treated with similar adjuvant therapy to UPSC/CC, which share similar clinical, immunohistochemistry and poor survival.
References
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Identification of a candidate tumour suppressor gene, MMAC1 , at chromosome 10q23.3 that is mutated in multiple advanced cancers
Peter A. Steck,Mark A. Pershouse,Samar A. Jasser,W. K. A. Yung,Huai Lin,Azra H. Ligon,Lauren A. Langford,Michelle Baumgard,T. Hattier,Thaylon Davis,Cheryl Frye,Rong Hu,Bradley D. Swedlund,David H. F. Teng,Sean V. Tavtigian +14 more
TL;DR: The results identify a strong candidate tumour suppressor gene at chromosome 10q23.3, whose loss of function appears to be associated with the oncogenesis of multiple human cancers.
Journal ArticleDOI
Two pathogenetic types of endometrial carcinoma
TL;DR: The author presents a hypothesis that the complex of endocrine and metabolic disturbances arising long before the development of endometrial carcinoma determines the biological peculiarities of the tumor, its clinical course, and the prognosis of the disease.
Journal ArticleDOI
The Cytoplasmic Domain of the Cell Adhesion Molecule Uvomorulin Associates With Three Independent Proteins Structurally Related in Different Species
TL;DR: The characterization of 102, 88 and 80 kd proteins provides a first molecular basis for a possible cytoplasmic anchorage of uvomorulin to the cytoskeleton and proposes the nomenclature of catenin alpha, beta and gamma respectively.
Journal ArticleDOI
PI 3-kinase, Akt and cell survival.
TL;DR: Novel connections between the metabolic effects of Akt and its control of survival have recently been made and the mechanisms for PI 3-kinase survival signalling are becoming clear.
Journal ArticleDOI
Altered PTEN Expression as a Diagnostic Marker for the Earliest Endometrial Precancers
George L. Mutter,Ming Chieh Lin,Jeffrey T. Fitzgerald,Jennifer B. Kum,Jan P. A. Baak,Jacqueline A. Lees,Liang Ping Weng,Charis Eng +7 more
TL;DR: Loss of PTEN function by mutational or other mechanisms is an early event in endometrial tumorigenesis that may occur in response to known endocrine risk factors and offers an informative immunohistochemical biomarker for premalignant disease.
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