Obesity is associated with increased seminal insulin and leptin alongside reduced fertility parameters in a controlled male cohort
Reads0
Chats0
TLDR
Hyperinsulinaemia and hyperleptinaemia are associated with increased seminal insulin and leptin concentrations, which may negatively impact male reproductive function in obesity, and insulin was also found to be highly concentrated in the seminal plasma of both groups.Abstract:
Obesity appears to be associated with male reproductive dysfunction and infertility, although this has been inconsistent and inconclusive. Insulin and leptin are known mediators and modulators of the hypothalamus-pituitary-testes axis, contributing to the regulation of male reproductive potential and overall wellbeing. These hormones are also present in semen influencing sperm functions. Although abdominal obesity is closely associated with insulin resistance (hyperinsulinaemia), hyperleptinaemia and glucose dysfunction, changes in seminal plasma concentrations of insulin, leptin and glucose in obese males has not previously been investigated. This small case controlled study assessed serum and seminal concentrations of insulin, leptin and glucose in obese (BMI > =30; n = 23) and non-obese (BMI < 30; n = 19) males. Following a detailed medical history and examination, participants meeting the inclusion criteria were entered for data analysis. Body parameters such as BMI, waist and hip circumference and the waist hip ratio were measured. Serum and semen samples were collected and assayed for insulin, leptin and glucose. Semen samples also underwent a standard semen analysis, with sperm mitochondrial membrane potential (MMP) and DNA fragmentation (DF). Obesity was associated with increased serum and seminal insulin and leptin, with no significant difference in seminal glucose. Serum and seminal concentrations of insulin and leptin were positively correlated. Furthermore, obesity was associated with decreased sperm concentration, sperm vitality and increased MMP and DF, with a non-significant impact on motility and morphology. Hyperinsulinaemia and hyperleptinaemia are associated with increased seminal insulin and leptin concentrations, which may negatively impact male reproductive function in obesity. Insulin was also found to be highly concentrated in the seminal plasma of both groups. This data will contribute to the contradictive information available in the literature on the impact of obesity and male reproduction.read more
Citations
More filters
Journal ArticleDOI
Sperm epigenetics and influence of environmental factors.
Ida Donkin,Romain Barrès +1 more
TL;DR: This review will summarize current knowledge about the different epigenetic signals in sperm that are responsive to environmental and lifestyle factors and are capable of affecting embryonic development and the phenotype of the offspring later in life.
Journal ArticleDOI
Peri-conception parental obesity, reproductive health, and transgenerational impacts
TL;DR: Maternal and paternal obesity prior to conception alters the molecular composition of both oocytes and sperm, which can partly escape epigenetic reprogramming at fertilization, altering the developmental trajectory of the resultant embryo, ultimately increasing the incidence of obesity and metabolic disorders in offspring.
Journal ArticleDOI
Obesity, energy balance and spermatogenesis.
Pedro Oliveira,Mário Sousa,Branca M. Silva,Mariana P. Monteiro,Mariana P. Monteiro,Marco G. Alves +5 more
TL;DR: How energy balance may modulate hormonal signalling and sperm quality in overweight and obese men and how lifestyle modifications and sustained weight loss may revert some of the deleterious effects of obesity in men and their offspring is proposed.
Journal ArticleDOI
Do lifestyle practices impede male fertility
Kristian Leisegang,Sulagna Dutta +1 more
TL;DR: It is recommended that relevant lifestyle practices are investigated in clinical history of male infertility cases, particularly in unexplained or idiopathic male infertility, and Appropriate modification of detrimental lifestyle practices is further suggested and recommended in the management ofmale infertility.
Book ChapterDOI
Epigenetics of Obesity.
A Lopomo,E Burgio,Lucia Migliore +2 more
TL;DR: The molecular mechanisms involved in the epigenetic programming require a new and general pathogenic paradigm, the Developmental Origins of Health and Disease theory, to explain the current epidemiological transition, that is, the worldwide increase of chronic, degenerative, and inflammatory diseases such as obesity, diabetes, cardiovascular diseases, neurodegenerative diseases, and cancer.
References
More filters
Obesity : Preventing and managing the global epidemic
D. S. Akram,Arne Astrup,T. Atinmo,J. L. Boissin,George A. Bray,K. Carroll,P. Chitson,C. Chunming,William H. Dietz,James O. Hill,Eric Jéquier,C. Komodiki,Yuji Matsuzawa,W. F. Mollentze,K. Moosa,M.I. Noor,K.S. Reddy,Jacob C. Seidell,V. Tanphaichitr,Ricardo Uauy,Paul Zimmet +20 more
Journal ArticleDOI
Harmonizing the Metabolic Syndrome A Joint Interim Statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity
K. G. M. M. Alberti,Robert H. Eckel,Scott M. Grundy,Paul Zimmet,James I. Cleeman,Karen A. Donato,Jean Charles Fruchart,W. Philip T. James,Catherine M. Loria,Sidney C. Smith +9 more
TL;DR: It was agreed that there should not be an obligatory component, but that waist measurement would continue to be a useful preliminary screening tool, and a single set of cut points would be used for all components except waist circumference, for which further work is required.
Journal Article
Recent advances in the relationship between obesity, inflammation, and insulin resistance.
Jean-Philippe Bastard,Mustapha Maachi,Claire Lagathu,Minji Kim,Martine Caron,Hubert Vidal,Jacqueline Capeau,Bruno Fève +7 more
TL;DR: It can be considered that obesity corresponds to a sub-clinical inflammatory condition that promotes the production of pro-inflammatory factors involved in the pathogenesis of insulin resistance, including leptin, TNF-alpha, IL-6 and resistin.
Journal ArticleDOI
A comprehensive definition for metabolic syndrome.
TL;DR: A comprehensive definition for the metabolic syndrome and its key features would facilitate research into its causes and hopefully lead to new insights into pharmacologic and lifestyle treatment approaches.
Related Papers (5)
BMI in relation to sperm count: an updated systematic review and collaborative meta-analysis
Nathalie Sermondade,Céline Faure,Léopold Fezeu,A G Shayeb,Jens Peter Bonde,Tina Kold Jensen,M. van Wely,Jan Tan Cao,A. C. Martini,M Eskandar,Jorge E. Chavarro,Jorge E. Chavarro,S Koloszar,John M. Twigt,Cecilia Høst Ramlau-Hansen,Edson Borges,Francesco Lotti,Régine P.M. Steegers-Theunissen,B Zorn,Alex J. Polotsky,S. La Vignera,Brenda Eskenazi,Kelton Tremellen,E V Magnusdottir,I Fejes,Serge Hercberg,Rachel Levy,Sébastien Czernichow +27 more