Journal ArticleDOI
Opening the lid on piano-stool complexes: An account of ruthenium(II)–arene complexes with medicinal applications
Reads0
Chats0
TLDR
The origins of the field are described, the design of compounds that inhibit enzymes are designed, the application of multinuclear systems to act as drug delivery vehicles, and the development of bioanalytical and biophysical methods are highlighted to help elucidate the mechanisms by which these compounds function.About:
This article is published in Journal of Organometallic Chemistry.The article was published on 2014-02-01. It has received 226 citations till now.read more
Citations
More filters
Antitumour metal compounds: more than theme and variations
Michael A. Jakupec,Markus Galanski,Vladimir B. Arion,Christian G. Hartinger,Bernhard K. Keppler +4 more
TL;DR: The recent achievement of oxaliplatin for the treatment of colon cancer should not belie the imbalance between a plethora of investigated complexes and a very small number of clinically approved platinum drugs.
Journal ArticleDOI
Ferrocifen type anti cancer drugs.
TL;DR: It is shown here the different antitumoral approaches offered by ferrocifen derivatives, originally simple derivatives of tamoxifen, which over the course of their development have proved to possess remarkable structural and mechanistic diversity.
Journal ArticleDOI
The development of RAPTA compounds for the treatment of tumors
TL;DR: Ruthenium(II)-arene RAPTA-type compounds have been extensively explored for their medicinal properties and a comprehensive review of this class of compounds is provided in this article.
Journal ArticleDOI
Metal-based drugs that break the rules
TL;DR: This work highlights compounds that are apparently incompatible with the more classical (platinum-derived) concepts employed in the development of metal-based anticancer drugs, with respect to both compound design and the approaches used to validate their utility.
Journal ArticleDOI
Recent advances in supramolecular and biological aspects of arene ruthenium(II) complexes
TL;DR: A review of the recent developments of arene ruthenium complexes towards both supramolecular chemistry and biology can be found in this paper, where the authors focus on the recent development of these compounds towards both biology and chemistry.
References
More filters
Journal ArticleDOI
Antitumour metal compounds: more than theme and variations.
Michael A. Jakupec,Markus Galanski,Vladimir B. Arion,Christian G. Hartinger,Bernhard K. Keppler +4 more
TL;DR: The recent achievement of oxaliplatin for the treatment of colon cancer should not belie the imbalance between a plethora of investigated complexes and a very small number of clinically approved platinum drugs as discussed by the authors.
Journal ArticleDOI
In Vitro and in Vivo Evaluation of Ruthenium(II)−Arene PTA Complexes
Claudine Scolaro,Alberta Bergamo,Laura Brescacin,R. Delfino,Moreno Cocchietto,Gábor Laurenczy,Tilmann J. Geldbach,Gianni Sava,Paul J. Dyson +8 more
TL;DR: Results show that these ruthenium(II)-arene complexes can reduce the growth of lung metastases in CBA mice bearing the MCa mammary carcinoma in the absence of a corresponding action at the site of primary tumor growth.
Journal ArticleDOI
Metal-based antitumour drugs in the post genomic era.
Paul J. Dyson,Gianni Sava +1 more
TL;DR: What the future holds for metal-based drugs, in particular anti-metastasis drugs,In these enlightened times of the post genomic era is discussed.
Antitumour metal compounds: more than theme and variations
Michael A. Jakupec,Markus Galanski,Vladimir B. Arion,Christian G. Hartinger,Bernhard K. Keppler +4 more
TL;DR: The recent achievement of oxaliplatin for the treatment of colon cancer should not belie the imbalance between a plethora of investigated complexes and a very small number of clinically approved platinum drugs.
Journal ArticleDOI
KP1019, a new redox-active anticancer agent--preclinical development and results of a clinical phase I study in tumor patients.
Christian G. Hartinger,Christian G. Hartinger,Michael A. Jakupec,Stefanie Zorbas-Seifried,Michael Groessl,Alexander E. Egger,Walter Berger,Haralabos Zorbas,Paul J. Dyson,Bernhard K. Keppler +9 more
TL;DR: The experimental evidence for the proposed mode of action of this coordination compound is discussed, including transport into the cell via the transferrin cycle and activation by reduction.