Journal ArticleDOI
Opening the lid on piano-stool complexes: An account of ruthenium(II)–arene complexes with medicinal applications
Reads0
Chats0
TLDR
The origins of the field are described, the design of compounds that inhibit enzymes are designed, the application of multinuclear systems to act as drug delivery vehicles, and the development of bioanalytical and biophysical methods are highlighted to help elucidate the mechanisms by which these compounds function.About:
This article is published in Journal of Organometallic Chemistry.The article was published on 2014-02-01. It has received 226 citations till now.read more
Citations
More filters
Antitumour metal compounds: more than theme and variations
Michael A. Jakupec,Markus Galanski,Vladimir B. Arion,Christian G. Hartinger,Bernhard K. Keppler +4 more
TL;DR: The recent achievement of oxaliplatin for the treatment of colon cancer should not belie the imbalance between a plethora of investigated complexes and a very small number of clinically approved platinum drugs.
Journal ArticleDOI
Ferrocifen type anti cancer drugs.
TL;DR: It is shown here the different antitumoral approaches offered by ferrocifen derivatives, originally simple derivatives of tamoxifen, which over the course of their development have proved to possess remarkable structural and mechanistic diversity.
Journal ArticleDOI
The development of RAPTA compounds for the treatment of tumors
TL;DR: Ruthenium(II)-arene RAPTA-type compounds have been extensively explored for their medicinal properties and a comprehensive review of this class of compounds is provided in this article.
Journal ArticleDOI
Metal-based drugs that break the rules
TL;DR: This work highlights compounds that are apparently incompatible with the more classical (platinum-derived) concepts employed in the development of metal-based anticancer drugs, with respect to both compound design and the approaches used to validate their utility.
Journal ArticleDOI
Recent advances in supramolecular and biological aspects of arene ruthenium(II) complexes
TL;DR: A review of the recent developments of arene ruthenium complexes towards both supramolecular chemistry and biology can be found in this paper, where the authors focus on the recent development of these compounds towards both biology and chemistry.
References
More filters
Journal ArticleDOI
In silico evolution of substrate selectivity: comparison of organometallic ruthenium complexes with the anticancer drug cisplatin.
TL;DR: A comparative quantum chemical approach helps to clarify how the selectivity of anticancer metallopharmaceuticals towards potential biological targets can be controlled by metal and ligands.
Journal ArticleDOI
Rationalization of the inhibition activity of structurally related organometallic compounds against the drug target cathepsin B by DFT
Angela Casini,Fabio Edafe,Mikael Erlandsson,Luca Gonsalvi,Antonella Ciancetta,Nazzareno Re,Andrea Ienco,Luigi Messori,Maurizio Peruzzini,Paul J. Dyson +9 more
TL;DR: Initial structure-activity relationships have been defined with the calculated binding energies of the M-S bonds correlating well with the observed inhibition properties of the compounds, which showed similar enzyme inhibition properties to NAMI-A.
Journal ArticleDOI
DNA interactions of dinuclear RuII arene antitumor complexes in cell-free media
TL;DR: The concept for the design of interhelical and DNA-protein cross-linking agents based on dinuclear Ru(II) arene complexes with sufficiently long linkers between two Ru centers may result in new compounds which exhibit a variety of biological effects and can be also useful in nucleic acids research.
Journal ArticleDOI
Influence of Structural Variation on the Anticancer Activity of RAPTA-Type Complexes: ptn versus pta
Anna K. Renfrew,Andrew D. Phillips,Alexander E. Egger,Christian G. Hartinger,Sylvain S. Bosquain,Alexey A. Nazarov,Bernhard K. Keppler,Luca Gonsalvi,Maurizio Peruzzini,Paul J. Dyson +9 more
TL;DR: In this paper, the reactivity of the RAPTA complexes toward double-stranded oligonucleotides and the model protein ubiquitin was studied using Fourier transform ICR mass spectrometry (FT-ICR-MS) and gel electrophoresis.
Journal ArticleDOI
Anticancer Activity of Self-Assembled Molecular Rectangles via Arene-Ruthenium Acceptors and a New Unsymmetrical Amide Ligand.
Anurag Mishra,Hyunji Jung,Jeong Woo Park,Hong Kyeung Kim,Hyunuk Kim,Peter J. Stang,Ki-Whan Chi +6 more
TL;DR: The cytotoxicity of rectangle 5 was found to be considerably stronger against all cancer cell lines than that of the reference drug cisplatin, and the cytotoxicities of both rectangles have been established against Colo320 (colorectal cancer), A549 (lung cancer), MCF-7 (breast cancer) and H1299 ( lung cancer) human cancer cell Lines.