Journal ArticleDOI
Opening the lid on piano-stool complexes: An account of ruthenium(II)–arene complexes with medicinal applications
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TLDR
The origins of the field are described, the design of compounds that inhibit enzymes are designed, the application of multinuclear systems to act as drug delivery vehicles, and the development of bioanalytical and biophysical methods are highlighted to help elucidate the mechanisms by which these compounds function.About:
This article is published in Journal of Organometallic Chemistry.The article was published on 2014-02-01. It has received 226 citations till now.read more
Citations
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Antitumour metal compounds: more than theme and variations
Michael A. Jakupec,Markus Galanski,Vladimir B. Arion,Christian G. Hartinger,Bernhard K. Keppler +4 more
TL;DR: The recent achievement of oxaliplatin for the treatment of colon cancer should not belie the imbalance between a plethora of investigated complexes and a very small number of clinically approved platinum drugs.
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Ferrocifen type anti cancer drugs.
TL;DR: It is shown here the different antitumoral approaches offered by ferrocifen derivatives, originally simple derivatives of tamoxifen, which over the course of their development have proved to possess remarkable structural and mechanistic diversity.
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The development of RAPTA compounds for the treatment of tumors
TL;DR: Ruthenium(II)-arene RAPTA-type compounds have been extensively explored for their medicinal properties and a comprehensive review of this class of compounds is provided in this article.
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Metal-based drugs that break the rules
TL;DR: This work highlights compounds that are apparently incompatible with the more classical (platinum-derived) concepts employed in the development of metal-based anticancer drugs, with respect to both compound design and the approaches used to validate their utility.
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Recent advances in supramolecular and biological aspects of arene ruthenium(II) complexes
TL;DR: A review of the recent developments of arene ruthenium complexes towards both supramolecular chemistry and biology can be found in this paper, where the authors focus on the recent development of these compounds towards both biology and chemistry.
References
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Metal-based paullones as putative CDK inhibitors for antitumor chemotherapy.
Wolfgang F. Schmid,Roland O. John,Gerhard Mühlgassner,Petra Heffeter,Michael A. Jakupec,Markus Galanski,Walter Berger,Vladimir B. Arion,Bernhard K. Keppler +8 more
TL;DR: Antiproliferative activity in the low micromolar range was observed in vitro in three human cancer cell lines by means of MTT assays, and H-Thymidine incorporation assays revealed the compounds to lower the rate of DNA synthesis, and flow cytometric analyses showed cell cycle arrest mainly in G 0/ G 1 phase.
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Mass spectrometric analysis of ubiquitin–platinum interactions of leading anticancer drugs: MALDI versus ESI
Christian G. Hartinger,Wee Han Ang,Angela Casini,Luigi Messori,Bernhard K. Keppler,Paul J. Dyson +5 more
TL;DR: In this article, the authors compared matrix-assisted laser desorption/ionization (MALDI) and nanoelectrospray ionization mass spectrometry (nESI-MS) for the analysis of small protein-platinum anticancer drug interactions.
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Bio-Metallodendrimers – Emerging Strategies in Metal-Based Drug Design
TL;DR: Progress made in the application of metallodendrimers as scaffolds for drug delivery, as metal-based drugs in their own right, and as agents for biosensing, photothermal and photodynamic therapy are described.
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Pyrone derivatives and metals: From natural products to metal-based drugs
Wolfgang Kandioller,Andrea Kurzwernhart,Muhammad Hanif,Samuel M. Meier,Helena Henke,Bernhard K. Keppler,Christian G. Hartinger +6 more
TL;DR: Recent literature on the use of (thio)pyr(id)ones in bioinorganic chemistry with a focus on their metal ion chelating properties is summarized.
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Osmium(II)--versus ruthenium(II)--arene carbohydrate-based anticancer compounds: similarities and differences.
Muhammad Hanif,Alexey A. Nazarov,Alexey A. Nazarov,Christian G. Hartinger,Wolfgang Kandioller,Michael A. Jakupec,Vladimir B. Arion,Paul J. Dyson,Bernhard K. Keppler +8 more
TL;DR: Within this series of Os compounds, in vitro anticancer activity is highest for the most lipophilic chlorido complex dichlorido(eta(6)-p-cymene)(3,5,6-bicyclophosphite-1,2-O-cyclohexylidene-alpha-D-glucofuranoside)osmium(II).