Journal ArticleDOI
Opening the lid on piano-stool complexes: An account of ruthenium(II)–arene complexes with medicinal applications
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TLDR
The origins of the field are described, the design of compounds that inhibit enzymes are designed, the application of multinuclear systems to act as drug delivery vehicles, and the development of bioanalytical and biophysical methods are highlighted to help elucidate the mechanisms by which these compounds function.About:
This article is published in Journal of Organometallic Chemistry.The article was published on 2014-02-01. It has received 226 citations till now.read more
Citations
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Antitumour metal compounds: more than theme and variations
Michael A. Jakupec,Markus Galanski,Vladimir B. Arion,Christian G. Hartinger,Bernhard K. Keppler +4 more
TL;DR: The recent achievement of oxaliplatin for the treatment of colon cancer should not belie the imbalance between a plethora of investigated complexes and a very small number of clinically approved platinum drugs.
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Ferrocifen type anti cancer drugs.
TL;DR: It is shown here the different antitumoral approaches offered by ferrocifen derivatives, originally simple derivatives of tamoxifen, which over the course of their development have proved to possess remarkable structural and mechanistic diversity.
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The development of RAPTA compounds for the treatment of tumors
TL;DR: Ruthenium(II)-arene RAPTA-type compounds have been extensively explored for their medicinal properties and a comprehensive review of this class of compounds is provided in this article.
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Metal-based drugs that break the rules
TL;DR: This work highlights compounds that are apparently incompatible with the more classical (platinum-derived) concepts employed in the development of metal-based anticancer drugs, with respect to both compound design and the approaches used to validate their utility.
Journal ArticleDOI
Recent advances in supramolecular and biological aspects of arene ruthenium(II) complexes
TL;DR: A review of the recent developments of arene ruthenium complexes towards both supramolecular chemistry and biology can be found in this paper, where the authors focus on the recent development of these compounds towards both biology and chemistry.
References
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Journal ArticleDOI
Self‐Assembly of Ambidentate Pyridyl‐Carboxylate Ligands with Octahedral Ruthenium Metal Centers: Self‐Selection for a Single‐Linkage Isomer and Anticancer‐Potency Studies
Hyunji Jung,Abhishek Dubey,Hyun Jung Koo,Vaishali Vajpayee,Timothy R. Cook,Hyunuk Kim,Se Chan Kang,Peter J. Stang,Ki-Whan Chi +8 more
TL;DR: The synthesis of six new [2+2] metallarectangles through the coordination-driven self-assembly of octahedral Ru(II)-based acceptors with ambidentate pyridyl-carboxylate donors is described, with cytotoxicities that were particularly high against AGS cancer cells, with IC50 values that were comparable to that of reference drug cisplatin.
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Am(m)ines Make the Difference: Organoruthenium Am(m)ine Complexes and Their Chemistry in Anticancer Drug Development
Maria V. Babak,Samuel M. Meier,Anton A. Legin,Mahsa S. Adib Razavi,Alexander Roller,Michael A. Jakupec,Bernhard K. Keppler,Christian G. Hartinger,Christian G. Hartinger +8 more
TL;DR: In general, complexes with biphenyl as arene ligand inhibited the growth of tumor cells more effectively than the cymene analogues, consistent with the increase in lipophilicity.
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Acetal-Functionalized RAPTA Complexes for Conjugation and Labeling
TL;DR: RAPTA compounds derivatized with acetal groups via a pendant chain to the arene ligand were developed as a functional probe for selective postlabeling and tagging of covalent RAPTA adducts in cancer cells.
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Selective, Cytotoxic Organoruthenium(II) Full‐Sandwich Complexes: A Structural, Computational and In Vitro Biological Study
Bradley Thomas Loughrey,Benjamin V. Cunning,Peter Conrad Healy,Christopher L. Brown,Peter G. Parsons,Michael Lloyd Williams +5 more
TL;DR: In vitro cytotoxicity studies demonstrate these delocalized lipophilic cations to be potent growth inhibitors of eleven unique tumorigenic cell lines, while exhibiting significantly lower levels of toxicity towards both a normal human fibroblast and a mouse macrophage cell line.
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New ruthenium(II) mixed metallocene derived complexes: Synthesis, characterization by X-ray diffraction and evaluation on DNA interaction by atomic force microscopy
M. Helena Garcia,Andreia Valente,Pedro Florindo,Tânia S. Morais,M. Fátima M. Piedade,M. Fátima M. Piedade,M. Teresa Duarte,Virtudes Moreno,Francesc X. Avilés,Julia Loreno +9 more
TL;DR: In this paper, a new family of Ru(II) mixed metallocene complexes of the type [Ru(η5-C5H5)(η6-arene)][PF6] has been synthesized and fully characterized by NMR and UV-Vis spectroscopy.