Journal ArticleDOI
Opening the lid on piano-stool complexes: An account of ruthenium(II)–arene complexes with medicinal applications
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TLDR
The origins of the field are described, the design of compounds that inhibit enzymes are designed, the application of multinuclear systems to act as drug delivery vehicles, and the development of bioanalytical and biophysical methods are highlighted to help elucidate the mechanisms by which these compounds function.About:
This article is published in Journal of Organometallic Chemistry.The article was published on 2014-02-01. It has received 226 citations till now.read more
Citations
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Antitumour metal compounds: more than theme and variations
Michael A. Jakupec,Markus Galanski,Vladimir B. Arion,Christian G. Hartinger,Bernhard K. Keppler +4 more
TL;DR: The recent achievement of oxaliplatin for the treatment of colon cancer should not belie the imbalance between a plethora of investigated complexes and a very small number of clinically approved platinum drugs.
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Ferrocifen type anti cancer drugs.
TL;DR: It is shown here the different antitumoral approaches offered by ferrocifen derivatives, originally simple derivatives of tamoxifen, which over the course of their development have proved to possess remarkable structural and mechanistic diversity.
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The development of RAPTA compounds for the treatment of tumors
TL;DR: Ruthenium(II)-arene RAPTA-type compounds have been extensively explored for their medicinal properties and a comprehensive review of this class of compounds is provided in this article.
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Metal-based drugs that break the rules
TL;DR: This work highlights compounds that are apparently incompatible with the more classical (platinum-derived) concepts employed in the development of metal-based anticancer drugs, with respect to both compound design and the approaches used to validate their utility.
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Recent advances in supramolecular and biological aspects of arene ruthenium(II) complexes
TL;DR: A review of the recent developments of arene ruthenium complexes towards both supramolecular chemistry and biology can be found in this paper, where the authors focus on the recent development of these compounds towards both biology and chemistry.
References
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Mass spectrometric analysis of ubiquitin-platinum interactions of leading anticancer drugs: MALDI versus ESI
Christian G. Hartinger,Wee Han Ang,Angela Casini,Luigi Messori,Bernhard K. Keppler,Paul J. Dyson +5 more
TL;DR: The comparison of different ionization techniques, i.e. matrix-assisted laser desorption/ionization (MALDI) and nanoelectrospray ionization mass spectrometry (nESI-MS) for the analysis of small protein–platinum anticancer drug interactions, shows comparable results but MALDI showed a higher degree of fragmentation of the Ub–pl platinum conjugates.
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3-Hydroxyflavones vs. 3-hydroxyquinolinones: structure–activity relationships and stability studies on RuII(arene) anticancer complexes with biologically active ligands
Andrea Kurzwernhart,Wolfgang Kandioller,Éva A. Enyedy,Maria S. Novak,Michael A. Jakupec,Bernhard K. Keppler,Christian G. Hartinger,Christian G. Hartinger +7 more
TL;DR: To expand knowledge about the structure-activity relationships and to determine the impact of lipophilicity of the arene ligand and of the hydrolysis rate on anticancer activity, a series of novel 3-hydroxyflavone derived Ru(II)(η(6)-arene) complexes were synthesised.
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Dinuclear Ruthenium Ethylene Complexes: Syntheses, Structures, and Catalytic Applications in ATRA and ATRC Reactions
TL;DR: In this article, the authors present a Web of Science Record created on 2008-07-24, modified on 2017-05-12, with the purpose of preserving the record.
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Human Carbonic Anhydrase II as a host for piano-stool complexes bearing a sulfonamide anchor
TL;DR: d(6)-piano-stool complexes bearing an arylsulfonamide anchor display sub-micromolar affinity towards human Carbonic Anhydrase II (hCA II) and highlights the nature of the host-guest interactions.
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Intratumoral NAMI-A Treatment Triggers Metastasis Reduction, Which Correlates to CD44 Regulation and Tumor Infiltrating Lymphocyte Recruitment
Sabrina Pacor,Sonia Zorzet,Moreno Cocchietto,Marina Bacac,Marta Vadori,Claudia Turrin,Barbara Gava,Anna Castellarin,Gianni Sava +8 more
TL;DR: The usefulness of intratumor treatments as experimental preclinical model for studying in vivo the mechanism of tumor cell interactions after prolonged exposure to ruthenium-based compounds to be developed for metastasis inhibition is stressed.