Journal ArticleDOI
Opening the lid on piano-stool complexes: An account of ruthenium(II)–arene complexes with medicinal applications
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TLDR
The origins of the field are described, the design of compounds that inhibit enzymes are designed, the application of multinuclear systems to act as drug delivery vehicles, and the development of bioanalytical and biophysical methods are highlighted to help elucidate the mechanisms by which these compounds function.About:
This article is published in Journal of Organometallic Chemistry.The article was published on 2014-02-01. It has received 226 citations till now.read more
Citations
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Synthesis, characterization and interactions with 9-methylguanine of ruthenium(II) η6-arene complexes with aromatic diimines
TL;DR: In this paper, a comparative NMR study of the 9-methylguanine (9-MeG) complexes, with similar diimine complexes, revealed that the unimpeded rotation of 9-meG is hindered by interactions between the 9MeGO6 and the p-cymene aromatic proton H2 and, by the bulky shape of the pqn.
Journal ArticleDOI
Synthesis and reactivity of molybdenum(0) complexes containing sterically expanded arene ligands
TL;DR: In this paper, a series of sterically expanded arenes, containing one or more 1,2,3,4-tetrahydro-1,1,4,4tetramethyl substituents, were synthesized in high yield utilizing classic Friedel-Crafts alkylation conditions.
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Hydrolytically stable organometallic ruthenium complexes with glucose-based phosphite ligands
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Half-sandwich (Cp*)RhCl2 core complexes containing sulfur donor thiosemicarbazones: Synthesis, cytotoxic activity and human serum albumin binding studies
TL;DR: The rhodium complex 6 exhibits excellent cytotoxic effect and promising selectivity towards cancer cell lines and the binding efficacy of complex 6 with HSA has been assessed using fluorescence spectroscopic tools.
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Synthesis, crystal structure and catalytic activity in reductive amination of dichlorido(η6-p-cymene)(2′-dicyclohexylphosphanyl-2,6-dimethoxybiphenyl-κP)ruthenium(II)
Maria Makarova,Alexey A. Tsygankov,Olga Chusova,I. V. Lin’ko,Pavel V. Dorovatovskii,Yan V. Zubavichus +5 more
TL;DR: The synthesis, crystal structure and catalytic activity in reductive amination reactions of a new ruthenium complex are described.
References
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Journal ArticleDOI
Inhibition of Cell Division in Escherichia coli by Electrolysis Products from a Platinum Electrode
TL;DR: In E. coli, the presence of certain group VIIIb transition metal compounds in concentrations of about 1–10 parts per million of the metal in the culture medium causes an inhibition of the cell division process, which implies that the growth process is not markedly affected.
Journal ArticleDOI
Arene ruthenium(II) complexes formed by dehydrogenation of cyclohexadienes with ruthenium(III) trichloride
TL;DR: In this article, the same authors compared their results with available data on arene exchange in arenetricarbonylchromium complexes and discussed in terms of electronic and steric effects on metal-arene bonding.
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From bench to bedside – preclinical and early clinical development of the anticancer agent indazolium trans-[tetrachlorobis(1H-indazole)ruthenate(III)] (KP1019 or FFC14A)
Christian G. Hartinger,Stefanie Zorbas-Seifried,Michael A. Jakupec,Bernd Kynast,Haralabos Zorbas,Bernhard K. Keppler +5 more
TL;DR: The preclinical and early clinical development of KP1019 - from bench to bedside - is recapitulated and promising activity against certain types of tumors is observed.
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A Phase I and Pharmacological Study with Imidazolium-trans-DMSO-imidazole-tetrachlororuthenate, a Novel Ruthenium Anticancer Agent
Jeany M. Rademaker-Lakhai,Desiree H.J.G. van den Bongard,Dick Pluim,Jos H. Beijnen,Jan H.M. Schellens +4 more
TL;DR: The maximum-tolerated dose (MTD), profile of adverse events, and dose-limiting toxicity of NAMI-A in patients with solid tumors were determined and the ruthenium pharmacokinetic analysis revealed a linear relationship between dose and area under the concentration-time curve (AUC) of total and unbound rUThenium.
Journal ArticleDOI
Metals in Medicine
Zijian Guo,Peter J. Sadler +1 more
TL;DR: In the fight against cancer cisplatin, one of the world's best selling anticancer drugs, is being joined by other platinum, titanium, and ruthenium complexes, and metal-targeted organic agents show exciting clinical potential.