Journal ArticleDOI
Opening the lid on piano-stool complexes: An account of ruthenium(II)–arene complexes with medicinal applications
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TLDR
The origins of the field are described, the design of compounds that inhibit enzymes are designed, the application of multinuclear systems to act as drug delivery vehicles, and the development of bioanalytical and biophysical methods are highlighted to help elucidate the mechanisms by which these compounds function.About:
This article is published in Journal of Organometallic Chemistry.The article was published on 2014-02-01. It has received 226 citations till now.read more
Citations
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Antitumour metal compounds: more than theme and variations
Michael A. Jakupec,Markus Galanski,Vladimir B. Arion,Christian G. Hartinger,Bernhard K. Keppler +4 more
TL;DR: The recent achievement of oxaliplatin for the treatment of colon cancer should not belie the imbalance between a plethora of investigated complexes and a very small number of clinically approved platinum drugs.
Journal ArticleDOI
Ferrocifen type anti cancer drugs.
TL;DR: It is shown here the different antitumoral approaches offered by ferrocifen derivatives, originally simple derivatives of tamoxifen, which over the course of their development have proved to possess remarkable structural and mechanistic diversity.
Journal ArticleDOI
The development of RAPTA compounds for the treatment of tumors
TL;DR: Ruthenium(II)-arene RAPTA-type compounds have been extensively explored for their medicinal properties and a comprehensive review of this class of compounds is provided in this article.
Journal ArticleDOI
Metal-based drugs that break the rules
TL;DR: This work highlights compounds that are apparently incompatible with the more classical (platinum-derived) concepts employed in the development of metal-based anticancer drugs, with respect to both compound design and the approaches used to validate their utility.
Journal ArticleDOI
Recent advances in supramolecular and biological aspects of arene ruthenium(II) complexes
TL;DR: A review of the recent developments of arene ruthenium complexes towards both supramolecular chemistry and biology can be found in this paper, where the authors focus on the recent development of these compounds towards both biology and chemistry.
References
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Journal ArticleDOI
In vitro anticancer activity and biologically relevant metabolization of organometallic ruthenium complexes with carbohydrate-based ligands.
Isabella Berger,Muhammad Hanif,Alexey A. Nazarov,Alexey A. Nazarov,Christian G. Hartinger,Christian G. Hartinger,Roland O. John,Maxim L. Kuznetsov,Michael Groessl,Frédéric Schmitt,Olivier Zava,Florian Biba,Vladimir B. Arion,Markus Galanski,Michael A. Jakupec,Lucienne Juillerat-Jeanneret,Paul J. Dyson,Bernhard K. Keppler +17 more
TL;DR: In vitro studies revealed that the 3,5,6-bicyclophosphite-1,2-O-cyclohexylidene-alpha-D-glucofuranoside complex is the most cytotoxic compound in human cancer cell lines (IC50 values from 30 to 300 microM depending on the cell line).
Journal ArticleDOI
Transporting and Shielding Photosensitisers by Using Water‐Soluble Organometallic Cages: A New Strategy in Drug Delivery and Photodynamic Therapy
TL;DR: A strategy to overcome skin photosensitivity remains one of the main limitations in photodynamic therapy, in which the photosensitizer is hidden inside the hydrophobic cavity of a water-soluble organometallic cage.
Journal ArticleDOI
Water-Soluble Arene Ruthenium Complexes Containing a trans-1,2-Diaminocyclohexane Ligand as Enantioselective Transfer Hydrogenation Catalysts in Aqueous Solution
TL;DR: The enantiopure complexes 1-9 have been employed as catalysts for the transfer hydrogenation of acetophenone in aqueous solution using sodium formate and water as a hydrogen source as discussed by the authors.
Book ChapterDOI
Drug Delivery by Water-Soluble Organometallic Cages
TL;DR: This chapter gives a short history of coordination-driven self-assembly, with a special attention to organometallic metalla-cycles, especially those composed of half-sandwich complexes, which have been used as sensors, as anticancer agents, as well as drug carriers.
Journal ArticleDOI
Transfer Hydrogenation of Ketones and Catalytic Oxidation of Alcohols with Half-Sandwich Complexes of Ruthenium(II) Designed Using Benzene and Tridentate (S, N, E) Type Ligands (E = S, Se, Te)
Pradhumn Singh,Ajai K. Singh +1 more
TL;DR: In this paper, the authors have characterized 1H, 13C{1H}, 77Se{ 1H}, and 125Te{1h} NMR spectroscopy and X-ray crystallography.