Journal ArticleDOI
Opening the lid on piano-stool complexes: An account of ruthenium(II)–arene complexes with medicinal applications
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TLDR
The origins of the field are described, the design of compounds that inhibit enzymes are designed, the application of multinuclear systems to act as drug delivery vehicles, and the development of bioanalytical and biophysical methods are highlighted to help elucidate the mechanisms by which these compounds function.About:
This article is published in Journal of Organometallic Chemistry.The article was published on 2014-02-01. It has received 226 citations till now.read more
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Synthesis, Structure, DNA/Protein Binding, and Anticancer Activity of Some Half-Sandwich Cyclometalated Rh(III) and Ir(III) Complexes
Sujay Mukhopadhyay,Rakesh Kumar Gupta,Rajendra Prasad Paitandi,Nishant Kumar Rana,Gunjan Sharma,Biplob Koch,Love Karan Rana,Maninder Singh Hundal,Daya Shankar Pandey +8 more
TL;DR: The Schiff base ligands benzylidene(4-tert-butylphenyl)amine 4-methyl ester (L1), (4-nitrobenzylidenes)(4-TERT-phenyl)-amine (L2), and 4-cyanobenzylideni(4tertbutyl phenyl)amines (L3) have been synthesized as discussed by the authors.
Journal ArticleDOI
Fighting Cancer with Transition Metal Complexes: From Naked DNA to Protein and Chromatin Targeting Strategies
Giulia Palermo,Alessandra Magistrato,Tina Riedel,Thibaud von Erlach,Curt A. Davey,Paul J. Dyson,Ursula Rothlisberger +6 more
TL;DR: This contribution aims at providing relevant information that may help in the rational design of novel drug‐discovery strategies and to demonstrate how the interplay between molecular simulations and experiments can make important contributions to elucidating the target preferences of some promising transition metal anticancer agents.
Journal ArticleDOI
Thiolato-bridged dinuclear arene ruthenium complexes and their potential as anticancer drugs
Julien Furrer,Georg Süss-Fink +1 more
TL;DR: In this paper, the authors describe the discovery of thiolato-bridged dinuclear arene ruthenium complexes and highlight subsequent developments in the field, including their syntheses, structures, and the recent strategies for the design of Thiolatobridged Dinuclear Arene RUThenium Bioconjugates.
Journal ArticleDOI
Investigation into antiproliferative activity and apoptosis mechanism of new arene Ru(II) carbazole-based hydrazone complexes
Thangavel Sathiya Kamatchi,Mohamed Kasim Mohamed Subarkhan,Rengan Ramesh,Hangxiang Wang,Jan Grzegorz Małecki +4 more
TL;DR: The synthesis of three new arene Ru(ii) complexes containing new carbazole-based hydrazone ligands of general formula, and their anticancer properties are described, shows the promising scope and potency of tailored arene ruthenium complexes for precise cancer chemotherapy beyond platinum drugs.
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Interactions between proteins and Ru compounds of medicinal interest: A structural perspective
TL;DR: In this article, a review of relevant crystallographic studies focused on the characterization of the interaction between proteins and selected ruthenium compounds of medicinal interest is presented, where details of the interactions between Ru compounds and protein residues are described and the reactivity of the compounds towards different targets is compared with that observed analyzing analogous Pt-based drugs-protein adducts.
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Journal ArticleDOI
Inhibition of Cell Division in Escherichia coli by Electrolysis Products from a Platinum Electrode
TL;DR: In E. coli, the presence of certain group VIIIb transition metal compounds in concentrations of about 1–10 parts per million of the metal in the culture medium causes an inhibition of the cell division process, which implies that the growth process is not markedly affected.
Journal ArticleDOI
Arene ruthenium(II) complexes formed by dehydrogenation of cyclohexadienes with ruthenium(III) trichloride
TL;DR: In this article, the same authors compared their results with available data on arene exchange in arenetricarbonylchromium complexes and discussed in terms of electronic and steric effects on metal-arene bonding.
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From bench to bedside – preclinical and early clinical development of the anticancer agent indazolium trans-[tetrachlorobis(1H-indazole)ruthenate(III)] (KP1019 or FFC14A)
Christian G. Hartinger,Stefanie Zorbas-Seifried,Michael A. Jakupec,Bernd Kynast,Haralabos Zorbas,Bernhard K. Keppler +5 more
TL;DR: The preclinical and early clinical development of KP1019 - from bench to bedside - is recapitulated and promising activity against certain types of tumors is observed.
Journal ArticleDOI
A Phase I and Pharmacological Study with Imidazolium-trans-DMSO-imidazole-tetrachlororuthenate, a Novel Ruthenium Anticancer Agent
Jeany M. Rademaker-Lakhai,Desiree H.J.G. van den Bongard,Dick Pluim,Jos H. Beijnen,Jan H.M. Schellens +4 more
TL;DR: The maximum-tolerated dose (MTD), profile of adverse events, and dose-limiting toxicity of NAMI-A in patients with solid tumors were determined and the ruthenium pharmacokinetic analysis revealed a linear relationship between dose and area under the concentration-time curve (AUC) of total and unbound rUThenium.
Journal ArticleDOI
Metals in Medicine
Zijian Guo,Peter J. Sadler +1 more
TL;DR: In the fight against cancer cisplatin, one of the world's best selling anticancer drugs, is being joined by other platinum, titanium, and ruthenium complexes, and metal-targeted organic agents show exciting clinical potential.