Journal ArticleDOI
Opening the lid on piano-stool complexes: An account of ruthenium(II)–arene complexes with medicinal applications
Reads0
Chats0
TLDR
The origins of the field are described, the design of compounds that inhibit enzymes are designed, the application of multinuclear systems to act as drug delivery vehicles, and the development of bioanalytical and biophysical methods are highlighted to help elucidate the mechanisms by which these compounds function.About:
This article is published in Journal of Organometallic Chemistry.The article was published on 2014-02-01. It has received 226 citations till now.read more
Citations
More filters
Journal ArticleDOI
Ferrocenyl Quinone Methide-Thiol Adducts as New Antiproliferative Agents: Synthesis, Metabolic Formation from Ferrociphenols, and Oxidative Transformation.
Yong Wang,Yong Wang,Marie-Aude Richard,Marie-Aude Richard,Siden Top,Siden Top,Patrick M. Dansette,Pascal Pigeon,Pascal Pigeon,Anne Vessières,Anne Vessières,Daniel Mansuy,Gérard Jaouen,Gérard Jaouen +13 more
TL;DR: To evaluate the reactivity of FC-QMs toward cellular nucleophiles, this work studied their reaction with selected thiols and synthesized and completely characterized the FC-SR adducts, which exhibit antiproliferative properties comparable to those of their FC precursors.
Journal ArticleDOI
Effect of the Piperazine Unit and Metal-Binding Site Position on the Solubility and Anti-Proliferative Activity of Ruthenium(II)- and Osmium(II)- Arene Complexes of Isomeric Indolo[3,2-c]quinoline—Piperazine Hybrids
TL;DR: The results provide important insight into the structure–activity relationships of ruthenium- and osmium-arene complexes with indoloquinoline–piperazine hybrid ligands and can be further utilized for the design and development of more potent chemotherapeutic agents.
Journal ArticleDOI
Evaluation of trimetallic Ru(II)- and Os(II)-Arene complexes as potential anticancer agents
TL;DR: Schiff-base ligands, tris-2-(salicylaldimine ethyl)amine and tris 2-(2-pyridylimine methyl)amine (1 and 2) were prepared and complexed to Ru(II) and Os(II), entities to form new trimetallic complexes (3-10) and have been characterized fully using elemental analysis, FT-IR and NMR spectroscopy as well as HR-ESI-TOF-MS spectrometry.
Journal ArticleDOI
Synthesis, Characterization, and Biological Properties of Osmium-Based Tamoxifen Derivatives - Comparison with Their Homologues in the Iron and Ruthenium Series
Hui Zhi Shirley Lee,Olivier Buriez,François Chau,François Chau,Eric Labbé,Rakesh Ganguly,Christian Amatore,Gérard Jaouen,Gérard Jaouen,Gérard Jaouen,Anne Vessières,Anne Vessières,Weng Kee Leong,Siden Top,Siden Top +14 more
TL;DR: Differences in the mechanisms of action that exist among the complexes of these three metallocenes are revealed and the cytotoxicity of the tamoxifen-like complexes of osmium and ruthenium is demonstrated.
Journal ArticleDOI
Self-assembled ruthenium (II) metallacycles and metallacages with imidazole-based ligands and their in vitro anticancer activity
Yibo Zhao,Yibo Zhao,Liqian Zhang,Xu Li,Yanhui Shi,Ruru Ding,Mengting Teng,Peng Zhang,Changsheng Cao,Peter J. Stang +9 more
TL;DR: Self-assembled compounds containing the 5,8-dioxido-1,4-naphtoquinonato scaffold exhibited enhanced anticancer activity on colon, breast, cervical, lung, and liver cancer cells, and decreased cytotoxicities in HEB and THLE-2 normal cells.
References
More filters
Journal ArticleDOI
Inhibition of Cell Division in Escherichia coli by Electrolysis Products from a Platinum Electrode
TL;DR: In E. coli, the presence of certain group VIIIb transition metal compounds in concentrations of about 1–10 parts per million of the metal in the culture medium causes an inhibition of the cell division process, which implies that the growth process is not markedly affected.
Journal ArticleDOI
Arene ruthenium(II) complexes formed by dehydrogenation of cyclohexadienes with ruthenium(III) trichloride
TL;DR: In this article, the same authors compared their results with available data on arene exchange in arenetricarbonylchromium complexes and discussed in terms of electronic and steric effects on metal-arene bonding.
Journal ArticleDOI
From bench to bedside – preclinical and early clinical development of the anticancer agent indazolium trans-[tetrachlorobis(1H-indazole)ruthenate(III)] (KP1019 or FFC14A)
Christian G. Hartinger,Stefanie Zorbas-Seifried,Michael A. Jakupec,Bernd Kynast,Haralabos Zorbas,Bernhard K. Keppler +5 more
TL;DR: The preclinical and early clinical development of KP1019 - from bench to bedside - is recapitulated and promising activity against certain types of tumors is observed.
Journal ArticleDOI
A Phase I and Pharmacological Study with Imidazolium-trans-DMSO-imidazole-tetrachlororuthenate, a Novel Ruthenium Anticancer Agent
Jeany M. Rademaker-Lakhai,Desiree H.J.G. van den Bongard,Dick Pluim,Jos H. Beijnen,Jan H.M. Schellens +4 more
TL;DR: The maximum-tolerated dose (MTD), profile of adverse events, and dose-limiting toxicity of NAMI-A in patients with solid tumors were determined and the ruthenium pharmacokinetic analysis revealed a linear relationship between dose and area under the concentration-time curve (AUC) of total and unbound rUThenium.
Journal ArticleDOI
Metals in Medicine
Zijian Guo,Peter J. Sadler +1 more
TL;DR: In the fight against cancer cisplatin, one of the world's best selling anticancer drugs, is being joined by other platinum, titanium, and ruthenium complexes, and metal-targeted organic agents show exciting clinical potential.