Journal ArticleDOI
Opening the lid on piano-stool complexes: An account of ruthenium(II)–arene complexes with medicinal applications
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TLDR
The origins of the field are described, the design of compounds that inhibit enzymes are designed, the application of multinuclear systems to act as drug delivery vehicles, and the development of bioanalytical and biophysical methods are highlighted to help elucidate the mechanisms by which these compounds function.About:
This article is published in Journal of Organometallic Chemistry.The article was published on 2014-02-01. It has received 226 citations till now.read more
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Anticancer activity of Ru- and Os(arene) compounds of a maleimide-functionalized bioactive pyridinecarbothioamide ligand.
Muhammad Hanif,Sally Moon,Matthew P. Sullivan,Sanam Movassaghi,Mario Kubanik,David C. Goldstone,Tilo Söhnel,Stephen M. F. Jamieson,Christian G. Hartinger +8 more
TL;DR: In vitro cytotoxicity studies revealed low potency which is explained by the observed high reactivity of the maleimide to the thiol of l-cysteine (Cys), while the metal center itself shows little affinity to amino acids of the model protein lysozyme.
Journal ArticleDOI
Insights into the in vitro Anticancer Effects of Diruthenium-1
Aneta Koceva-Chyła,Karolina Matczak,Msc. Paweł Hikisz,Msc. Kamil Durka,Msc. Krzysztof Kochel,Georg Süss-Fink,Julien Furrer,Konrad Kowalski +7 more
TL;DR: The results show that DiRu‐1 triggers caspase‐dependent apoptosis in MCF‐7 cells on both the intrinsic and extrinsic pathways, and the Ru complex also causes necrosis, mitotic catastrophe, and autophagy.
Journal ArticleDOI
Binding mechanisms of half-sandwich Rh(III) and Ru(II) arene complexes on human serum albumin: a comparative study.
Orsolya Dömötör,Éva A. Enyedy +1 more
TL;DR: Fast, non-specific and high-affinity binding of the complexes on HSA highlights their coordinative interaction with various types of proteins possibly decreasing effective drug concentration.
Journal ArticleDOI
Synthesis, structures, and DNA and protein binding of ruthenium(II)-p-cymene complexes of substituted pyridylimidazo[1,5-a]pyridine: enhanced cytotoxicity of complexes of ligands appended with a carbazole moiety
Themmila Khamrang,Radhakrishnan Kartikeyan,Marappan Velusamy,Venugopal Rajendiran,Rajakumar Dhivya,Balaji Perumalsamy,Mohammad Abdulkadher Akbarsha,Mallayan Palaniandavar +7 more
TL;DR: A series of organometallic Ru(II)-arene complexes of the type [(η6-p-cymene)Ru(L)Cl]-BF4) 1-6, where L is 3-phenyl-1-pyridin-2-yl-imidazo[1,5-a]pyridine (L1), dimethyl-[4-(1-polygonal polycyclic acid)-dimethyl]-9H-carbazole (L4), diphenyl-[4]-4-( 1-polycyclic
Journal ArticleDOI
First- and Second-Generation Heterometallic Dendrimers Containing Ferrocenyl–Ruthenium(II)–Arene Motifs: Synthesis, Structure, Electrochemistry, and Preliminary Cell Proliferation Studies
Preshendren Govender,Heidi Lemmerhirt,Alan T. Hutton,Bruno Therrien,Patrick J. Bednarski,Gregory S. Smith +5 more
TL;DR: In this paper, first and second generation heterometallic ferrocenyl derived p-cymene-Ru(II) metallodendrimers have been synthesized.
References
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Journal ArticleDOI
Inhibition of Cell Division in Escherichia coli by Electrolysis Products from a Platinum Electrode
TL;DR: In E. coli, the presence of certain group VIIIb transition metal compounds in concentrations of about 1–10 parts per million of the metal in the culture medium causes an inhibition of the cell division process, which implies that the growth process is not markedly affected.
Journal ArticleDOI
Arene ruthenium(II) complexes formed by dehydrogenation of cyclohexadienes with ruthenium(III) trichloride
TL;DR: In this article, the same authors compared their results with available data on arene exchange in arenetricarbonylchromium complexes and discussed in terms of electronic and steric effects on metal-arene bonding.
Journal ArticleDOI
From bench to bedside – preclinical and early clinical development of the anticancer agent indazolium trans-[tetrachlorobis(1H-indazole)ruthenate(III)] (KP1019 or FFC14A)
Christian G. Hartinger,Stefanie Zorbas-Seifried,Michael A. Jakupec,Bernd Kynast,Haralabos Zorbas,Bernhard K. Keppler +5 more
TL;DR: The preclinical and early clinical development of KP1019 - from bench to bedside - is recapitulated and promising activity against certain types of tumors is observed.
Journal ArticleDOI
A Phase I and Pharmacological Study with Imidazolium-trans-DMSO-imidazole-tetrachlororuthenate, a Novel Ruthenium Anticancer Agent
Jeany M. Rademaker-Lakhai,Desiree H.J.G. van den Bongard,Dick Pluim,Jos H. Beijnen,Jan H.M. Schellens +4 more
TL;DR: The maximum-tolerated dose (MTD), profile of adverse events, and dose-limiting toxicity of NAMI-A in patients with solid tumors were determined and the ruthenium pharmacokinetic analysis revealed a linear relationship between dose and area under the concentration-time curve (AUC) of total and unbound rUThenium.
Journal ArticleDOI
Metals in Medicine
Zijian Guo,Peter J. Sadler +1 more
TL;DR: In the fight against cancer cisplatin, one of the world's best selling anticancer drugs, is being joined by other platinum, titanium, and ruthenium complexes, and metal-targeted organic agents show exciting clinical potential.