Organization and execution of the epithelial polarity programme
Reads0
Chats0
TLDR
Insight is provided into the interactions of the EPP with the polarized trafficking machinery and how these regulate epithelial polarization and depolarization.Abstract:
The epithelial polarity programme (EPP) is organized in response to extracellular cues and executed through the establishment of an apical–basal axis, intercellular junctions, epithelial-specific cytoskeletal rearrangements and a polarized trafficking machinery. Recent studies have provided insights into the interactions of the EPP with the polarized trafficking machinery and how they regulate epithelial polarization and depolarization. Epithelial cells require apical–basal plasma membrane polarity to carry out crucial vectorial transport functions and cytoplasmic polarity to generate different cell progenies for tissue morphogenesis. The establishment and maintenance of a polarized epithelial cell with apical, basolateral and ciliary surface domains is guided by an epithelial polarity programme (EPP) that is controlled by a network of protein and lipid regulators. The EPP is organized in response to extracellular cues and is executed through the establishment of an apical–basal axis, intercellular junctions, epithelial-specific cytoskeletal rearrangements and a polarized trafficking machinery. Recent studies have provided insight into the interactions of the EPP with the polarized trafficking machinery and how these regulate epithelial polarization and depolarization.read more
Citations
More filters
Journal ArticleDOI
Actin–microtubule crosstalk in cell biology
TL;DR: The cytoskeleton should be considered not as a collection of individual parts but rather as a unified system in which subcomponents co-regulate each other to exert their functions in a precise and highly adaptable manner.
Journal ArticleDOI
Oral absorption of peptides and nanoparticles across the human intestine: Opportunities, limitations and studies in human tissues.
Patrik Lundquist,Per Artursson +1 more
TL;DR: The opportunities and predictivity of various in vitro systems with special emphasis on human intestine in Ussing chambers are discussed, and characteristics of common in vitro cell culture systems are discussed and compared to those of human intestinal tissues.
Journal ArticleDOI
EMT: Mechanisms and therapeutic implications
TL;DR: The sequence of events and defining mechanisms that take place during EMT are described, and how these interactions drive cancer cell progression into metastasis are described.
Journal ArticleDOI
Genome-wide association meta-analysis identifies five modifier loci of lung disease severity in cystic fibrosis
Harriet Corvol,Harriet Corvol,Scott M. Blackman,Pierre-Yves Boëlle,Paul J. Gallins,Rhonda G. Pace,Jaclyn R. Stonebraker,Frank J. Accurso,Frank J. Accurso,Annick Clement,Annick Clement,Joseph M. Collaco,Hong Dang,Anthony T. Dang,Arianna Franca,Jiafen Gong,Loïc Guillot,Katherine Keenan,Weili Li,Fan Lin,Michael V. Patrone,Karen S. Raraigh,Lei Sun,Yi-Hui Zhou,Wanda K. O'Neal,Marci K. Sontag,Marci K. Sontag,Hara Levy,Peter R. Durie,Johanna M. Rommens,Mitchell L. Drumm,Fred A. Wright,Lisa J. Strug,Garry R. Cutting,Michael R. Knowles +34 more
TL;DR: This paper used genome-wide association analysis to identify genetic modifiers of CF lung disease, the primary cause of mortality, and provided new insights into potential targets for modulating lung disease severity in CF.
References
More filters
Journal ArticleDOI
Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia
Catherine D. Nobes,Alan Hall +1 more
TL;DR: It is reported here that cdc42, another member of the rho family, triggers the formation of a third type of actin-based structure found at the cell periphery, filopodia, in addition to stress fibers, and rho controls the assembly of focal adhesion complexes.
Journal ArticleDOI
Rab proteins as membrane organizers
Marino Zerial,Heidi M. McBride +1 more
TL;DR: Cellular organelles in the exocytic and endocytic pathways have a distinctive spatial distribution and communicate through an elaborate system of vesiculo-tubular transport.
Journal ArticleDOI
The small GTP-binding protein rac regulates growth factor-induced membrane ruffling.
TL;DR: It is proposed that rac and rho are essential components of signal transduction pathways linking growth factors to the organization of polymerized actin and that growth factors act through rac to stimulate this rho-dependent response.
Journal ArticleDOI
Rho GTPases: Biochemistry and Biology
Aron B. Jaffe,Alan Hall +1 more
TL;DR: This review presents the best characterized of these biochemical pathways that control some of the most fundamental processes of cell biology common to all eukaryotes, including morphogenesis, polarity, movement, and cell division.
Journal ArticleDOI
Phosphoinositides in cell regulation and membrane dynamics
TL;DR: Inositol phospholipids mediate acute responses, but also act as constitutive signals that help define organelle identity, and play a fundamental part in controlling membrane–cytosol interfaces.