Journal ArticleDOI
Pain-resolving immune mechanisms in neuropathic pain
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This article is published in Nature Reviews Neurology.The article was published on 2023-03-01. It has received 4 citations till now. The article focuses on the topics: Medicine & Neuropathic pain.read more
Citations
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Developmental impact of peripheral injury on neuroimmune signaling
Journal ArticleDOI
Stabilizing the neural barrier - A novel approach in pain therapy.
TL;DR: In this paper , the authors discuss several mechanisms and putative targets for novel treatment strategies for chronic and neuropathic pain, including pericytes, local mediators like netrin-1 and specialized proresolving mediators.
Journal ArticleDOI
The therapeutic potential of natural killer cells in neuropathic pain
TL;DR: In this paper , the authors explored the potential cellular and molecular targets of NK cells in the PNS by contrasting with their reported functional roles in CNS diseases, and suggested strategies for using the beneficial functions of natural killer cells and immune-based therapeutics in the context of neuropathic pain.
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SAFit2 ameliorates paclitaxel-induced neuropathic pain by reducing spinal gliosis and elevating pro-resolving lipid mediators
Saskia Wedel,Lisa Hahnefeld,Yannick Schreiber,Ch. Namendorf,T. Heymann,Manfred Uhr,Mathias V. Schmidt,Natasja de Bruin,Felix Hausch,Dominique Thomas,Gerd Geisslinger,Marco Sisignano +11 more
TL;DR: In this paper , SAFit2 showed antihyperalgesic properties as it ameliorated paclitaxel-induced neuropathic pain by reducing peripheral sensitization and resolving neuroinflammation.
References
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Journal ArticleDOI
Cellular and Molecular Mechanisms of Pain
TL;DR: Genetic, electrophysiological, and pharmacological studies are elucidating the molecular mechanisms that underlie detection, coding, and modulation of noxious stimuli that generate pain.
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Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation
Nicholas Arpaia,Clarissa Campbell,Xiying Fan,Stanislav Dikiy,Joris van der Veeken,Paul deRoos,Hui Liu,Justin R. Cross,Klaus Pfeffer,Paul J. Coffer,Alexander Y. Rudensky +10 more
TL;DR: The results suggest that bacterial metabolites mediate communication between the commensal microbiota and the immune system, affecting the balance between pro- and anti-inflammatory mechanisms.
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Functions of natural killer cells
Eric Vivier,Elena Tomasello,Elena Tomasello,Myriam Baratin,Myriam Baratin,Thierry Walzer,Thierry Walzer,Sophie Ugolini,Sophie Ugolini +8 more
TL;DR: Although NK cells might appear to be redundant in several conditions of immune challenge in humans, NK cell manipulation seems to hold promise in efforts to improve hematopoietic and solid organ transplantation, promote antitumor immunotherapy and control inflammatory and autoimmune disorders.
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Structural and functional features of central nervous system lymphatic vessels
Antoine Louveau,Igor Smirnov,Timothy J. Keyes,Jacob D. Eccles,Sherin J. Rouhani,J. David Peske,Noël C. Derecki,David Castle,James Mandell,Kevin S. Lee,Tajie H. Harris,Jonathan Kipnis +11 more
TL;DR: In searching for T-cell gateways into and out of the meninges, functional lymphatic vessels lining the dural sinuses are discovered, which may call for a reassessment of basic assumptions in neuroimmunology and sheds new light on the aetiology of neuroinflammatory and neurodegenerative diseases associated with immune system dysfunction.
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Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis.
Nanna B. Finnerup,Nadine Attal,Simon Haroutounian,Ewan D McNicol,Ralf Baron,Robert H. Dworkin,Ian Gilron,Maija Haanpää,Per Hansson,Per Hansson,Troels S. Jensen,Troels S. Jensen,Peter R. Kamerman,Karen Lund,Andrew Moore,Srinivasa N. Raja,Andrew S.C. Rice,Andrew S.C. Rice,Michael C. Rowbotham,Emily S. Sena,Emily S. Sena,Philip J. Siddall,Philip J. Siddall,Blair H. Smith,Mark S. Wallace +24 more
TL;DR: The results support a revision of the NeuPSIG recommendations for the pharmacotherapy of neuropathic pain and allow a strong recommendation for use and proposal as first-line treatment in neuropathicPain for tricyclic antidepressants, serotonin-noradrenaline reuptake inhibitors, pregabalin, and gabapentin.