Peculiarities of cell death mechanisms in neutrophils.
Barbara Geering,Hans-Uwe Simon +1 more
TLDR
The current and emerging models of neutrophil cell death mechanisms are reviewed with a focus on neutrophils peculiarities, including mitochondrial death pathway, and pharmacological intervention of inflammation.Abstract:
Analyses of neutrophil death mechanisms have revealed many similarities with other cell types; however, a few important molecular features make these cells unique executors of cell death mechanisms. For instance, in order to fight invading pathogens, neutrophils possess a potent machinery to produce reactive oxygen species (ROS), the phagocyte nicotinamide adenine dinucleotide phosphate (NADPH) oxidase. Evidence is emerging that these ROS are crucial in the execution of most neutrophil cell death mechanisms. Likewise, neutrophils exhibit many diverse granules that are packed with cytotoxic mediators. Of those, cathepsins were recently shown to activate pro-apoptotic B-cell lymphoma-2 (Bcl-2) family members and caspases, thus acting on apoptosis regulators. Moreover, neutrophils have few mitochondria, which hardly participate in ATP synthesis, as neutrophils gain energy from glycolysis. In spite of relatively low levels of cytochrome c in these cells, the mitochondrial death pathway is functional. In addition to these pecularities defining neutrophil death pathways, neutrophils are terminally differentiated cells, hence they do not divide but undergo apoptosis shortly after maturation. The initial trigger of this spontaneous apoptosis remains to be determined, but may result from low transcription and translation activities in mature neutrophils. Due to the unique biological characteristics of neutrophils, pharmacological intervention of inflammation has revealed unexpected and sometimes disappointing results when neutrophils were among the prime target cells during therapy. In this study, we review the current and emerging models of neutrophil cell death mechanisms with a focus on neutrophil peculiarities.read more
Citations
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CD177+ cells produce neutrophil extracellular traps to promote biliary atresia.
Ruizhong Zhang,Liang Su,Ming Fu,Zhen Wang,Ledong Tan,Hongjiao Chen,Zefeng Lin,Yanlu Tong,Rongchen Ye,Ziyang Zhao,Ziqing Wang,Weiyi Chen,Jiakang Yu,W Zhong,Jixiao Zeng,Fei-Fei Liu,Chenwei Chai,Xi-Si Guan,Tao Liu,Jian-kun Liang,Yun Zhu,Xiaoqiong Gu,Yan Zhang,Vincent C.H. Lui,Paul K.H. Tam,Jonathan R. Lamb,Zhe Wen,Yan Kun Chen,Huimin Xia +28 more
TL;DR: In this paper , the role of neutrophils in the pathogenesis of biliary atresia (BA) was examined in Cd177-/- BALB/c mice.
Identification of distinct macrophage subpopulations during nitrogen mustard-induced lung injury and fibrosis: mechanisms of recruitment and activation
TL;DR: A chronology of key events and figures leading to and after World War II, as well as some of the more recent developments, are presented.
Journal ArticleDOI
Flow Cytometric Assessment of the Viability and Functionality of Uterine Polymorphonuclear Leukocytes in Postpartum Dairy Cows
Leen Lietaer,Kristel Demeyere,Stijn Heirbaut,Evelyne Meyer,Geert Opsomer,Osvaldo Américo Bogado Pascottini,Osvaldo Américo Bogado Pascottini +6 more
TL;DR: In this paper, the authors developed a method for endometrial PMN isolation and flow cytometric assessment of their viability and functionality, and evaluated PMN immunolabeling using a specific bovine granulocyte marker, CH138A.
Dissertation
Rôle pro-inflammatoire et immunomodulateur de la proteinase 3 membranaire exprimée au cours de l'apoptose : implications dans la granulomatose avec polyangéite
TL;DR: In this article, the authors show that the activation of macrophages in granulomatose avec polyangeite can be attributed to the presence of quatre acides amines formant un patch hydrophobe.
Journal ArticleDOI
Novel insight on marker genes and pathogenic peripheral neutrophil subtypes in acute pancreatitis
Deyu Zhang,Meiqi Wang,Yang Zhang,Chuanchao Xia,Lisi Peng,Ke Bin Li,Hua Yin,Shiyu Li,Xiaoli Yang,Xiaoju Su,Hao Huang +10 more
TL;DR: Through a combination analysis of bulk sequencing and single-cell sequencing data of COVID-19 patients, a pivotal subtype of neutrophils with strong activation of the interferon-related pathway was identified as a pivotal peripheral blood cell subtype for CO VID-19-induced acute pancreatitis.
References
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Journal ArticleDOI
Role of reactive oxygen species (ROS) in apoptosis induction
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Journal ArticleDOI
Novel cell death program leads to neutrophil extracellular traps
Tobias A. Fuchs,Ulrike Abu Abed,Christian Goosmann,Robert Hurwitz,Ilka Schulze,Volker Wahn,Yvette Weinrauch,Volker Brinkmann,Arturo Zychlinsky +8 more
TL;DR: This novel ROS-dependent death allows neutrophils to fulfill their antimicrobial function, even beyond their lifespan.
Journal ArticleDOI
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