Journal ArticleDOI
Peptide antigens for gamma/delta T cells
Willi K. Born,Li Zhang,Maki Nakayama,Niyun Jin,Jennifer L. Chain,Yafei Huang,M. Kemal Aydintug,Rebecca L. O'Brien,Rebecca L. O'Brien +8 more
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TLDR
To settle the questions of whether peptides can be ligands for the γδ TCRs, and whether responses to small peptides might occur normally, peptide binding will have to be demonstrated, and natural peptide ligands identified.Abstract:
γδ T cells express adaptive antigen receptors encoded by rearranging genes. Their diversity is highest in the small region of TCR V–J junctions, especially in the δ chain, which should enable the γδ TCRs to distinguish differences in small epitopes. Indeed, recognition of small molecules, and of an epitope on a larger protein has been reported. Responses to small non-peptides known as phospho-antigens are multi-clonal yet limited to a single γδ T cell subset in humans and non-human primates. Responses to small peptides are multi-clonal or oligo-clonal, include more than one subset of γδ T cells, and occur in rodents and primates. However, less effort has been devoted to investigate the peptide responses. To settle the questions of whether peptides can be ligands for the γδ TCRs, and whether responses to small peptides might occur normally, peptide binding will have to be demonstrated, and natural peptide ligands identified.read more
Citations
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γδ T cells: first line of defense and beyond.
TL;DR: Functional and molecular analyses indicate that in infections, γδ T cells respond earlier than αβ T cells do and that they emerge late after pathogen numbers start to decline, suggesting that these cells may be involved in both establishing and regulating the inflammatory response.
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Human CD1-restricted T-cell recognition of lipids from pollens
TL;DR: Evidence is provided that pollen lipids may be recognized as antigens by human T cells through a CD1-dependent pathway, and allergic, but not normal subjects, displayed circulating specific IgE and cutaneous weal and flare reactions to phospholipids.
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γδ-T cells: an unpolished sword in human anti-infection immunity
TL;DR: Although further investigation is needed to improve the understanding of the characteristics of different γδ-T cell subpopulations under specific conditions, γ ΔT cell-based therapy has great potential for the treatment of infectious diseases.
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Diversity of γδ T-cell antigens
TL;DR: In this paper, it was shown that αβ T cells recognize a diverse array of antigens including self and foreign, large and small, and peptidic and non-peptidic molecules.
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γδ T cell responses: How many ligands will it take till we know?
TL;DR: The latest progress in the identification and validation of putative γδ T cell ligands is reviewed and the implications of such findings for γ Δ T cell responses in health and disease are discussed.
References
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Journal ArticleDOI
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Journal ArticleDOI
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