Journal ArticleDOI
Personalizing Colon Cancer Adjuvant Therapy: Selecting Optimal Treatments for Individual Patients
TLDR
B biomarker analyses of multiple studies strongly support the feasibility of refining risk stratification in colon cancer by factoring in molecular characteristics with pathologic tumor staging, and the value of BRAF or KRAS mutations as additional risk factors in stage III disease is greater when microsatellite status and tumor location are taken into account.Abstract:
For more than three decades, postoperative chemotherapy—initially fluoropyrimidines and more recently combinations with oxaliplatin—has reduced the risk of tumor recurrence and improved survival for patients with resected colon cancer. Although universally recommended for patients with stage III disease, there is no consensus about the survival benefit of postoperative chemotherapy in stage II colon cancer. The most recent adjuvant clinical trials have not shown any value for adding targeted agents, namely bevacizumab and cetuximab, to standard chemotherapies in stage III disease, despite improved outcomes in the metastatic setting. However, biomarker analyses of multiple studies strongly support the feasibility of refining risk stratification in colon cancer by factoring in molecular characteristics with pathologic tumor staging. In stage II disease, for example, microsatellite instability supports observation after surgery. Furthermore, the value of BRAF or KRAS mutations as additional risk factors in s...read more
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Ten years of anti-vascular endothelial growth factor therapy
TL;DR: The discovery of V EGFA, the successes and challenges in the development of VEGFA inhibitors and the impact of these agents on the treatment of cancers and ophthalmic diseases are discussed.
Journal ArticleDOI
Clonal haemopoiesis and therapy-related myeloid malignancies in elderly patients: a proof-of-concept, case-control study
Nancy K. Gillis,Markus Ball,Qing Zhang,Zhenjun Ma,YuLong Zhao,Sean J. Yoder,Maria E. Balasis,Tania Mesa,David A. Sallman,Jeffrey E. Lancet,Rami S. Komrokji,Alan F. List,Howard L. McLeod,Melissa Alsina,Rachid Baz,Kenneth H. Shain,Dana E. Rollison,Eric Padron +17 more
TL;DR: The prevalence of CHIP in all patients was higher than has been reported in elderly individuals without cancer and the primary exposure was CHIP, suggesting that mutation-specific differences might exist in therapy-related myeloid neoplasm risk.
Journal ArticleDOI
Mismatch Repair Deficiency and Response to Immune Checkpoint Blockade
TL;DR: This article seeks to educate oncologists regarding the nature of mismatch repair deficiency, its impact in multiple tumor types, and its implications for predicting the responsiveness of solid tumors to immune checkpoint blockade.
Journal ArticleDOI
Biomarker-guided therapy for colorectal cancer: strength in complexity
TL;DR: An overview of current and emerging clinically relevant biomarkers and their role in the management of patients with CRC is provided, illustrating the intricacies of biomarker interactions and the growing treatment opportunities created by the availability of comprehensive molecular profiling.
Journal ArticleDOI
Tumour CD274 (PD-L1) expression and T cells in colorectal cancer
Yohei Masugi,Reiko Nishihara,Juhong Yang,Juhong Yang,Kosuke Mima,Annacarolina da Silva,Yan Shi,Kentaro Inamura,Yin Cao,Mingyang Song,Jonathan A. Nowak,Xiaoyun Liao,Katsuhiko Nosho,Andrew T. Chan,Andrew T. Chan,Marios Giannakis,Marios Giannakis,Marios Giannakis,Adam J. Bass,Adam J. Bass,Adam J. Bass,F. Stephen Hodi,Gordon J. Freeman,Gordon J. Freeman,Scott J. Rodig,Charles S. Fuchs,Charles S. Fuchs,Zhi Rong Qian,Shuji Ogino,Shuji Ogino +29 more
TL;DR: Tumour CD274 expression is inversely associated with FOXP3+ cell density in colorectal cancer tissue, suggesting a possible influence of CD274-expressing carcinoma cells on regulatory T cells in the tumour microenvironment.
References
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TL;DR: It is reported that angiogenesis inhibitors targeting the VEGF pathway demonstrate antitumor effects in mouse models of pancreatic neuroendocrine carcinoma and glioblastoma but concomitantly elicit tumor adaptation and progression to stages of greater malignancy, with heightened invasiveness and in some cases increased lymphatic and distant metastasis.
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