Pharmacokinetics and biodistribution of lonidamine/paclitaxel loaded, EGFR-targeted nanoparticles in an orthotopic animal model of multi-drug resistant breast cancer
Reads0
Chats0
TLDR
Lonidamine-paclitaxel combination therapy administered via EGFR-targeted polymer-blend nanocarriers may become a viable platform for the future treatment of multidrug-resistant cancer.About:
This article is published in Nanomedicine: Nanotechnology, Biology and Medicine.The article was published on 2011-08-01 and is currently open access. It has received 107 citations till now. The article focuses on the topics: Lonidamine & Biodistribution.read more
Citations
More filters
Journal ArticleDOI
Nanotechnology applied to overcome tumor drug resistance
TL;DR: This review focuses on recent literature examples of nanotechnology applications to overcome multidrug resistance to chemotherapy and the advantages and limitations of various nanotechnologies are discussed.
Journal ArticleDOI
Nanomedicine of synergistic drug combinations for cancer therapy – Strategies and perspectives
TL;DR: The rationale, principles, and advantages of applying nanocarriers to improve anticancer drug combination therapy are examined, the use of nanoccarriers for delivery of a variety of combinations of different classes of anticancer agents including small molecule drugs and biologics are reviewed, and the challenges and future perspectives are discussed.
Journal ArticleDOI
Mitochondria and cancer chemoresistance.
TL;DR: The current understanding of mitochondrial dysfunction in the context of cancer chemoresistance is described with special attention to the role of mtDNA alterations, and potential therapeutic strategies targeting different metabolic events specific to cancer cells are put emphasis.
Journal ArticleDOI
Biophysics of Cell Membrane Lipids in Cancer Drug Resistance: Implications for Drug Transport and Drug Delivery with Nanoparticles
TL;DR: Novel strategies for modulating the biophysical properties of membranelipids of resistant cells to facilitate drug transport and regain endocytic function are discussed and effective nanoparticles based on their biophysical interactions with membrane lipids to enhance drug delivery and overcome drug resistance are developed.
Journal ArticleDOI
Gadolinium loaded nanoparticles in theranostic magnetic resonance imaging
Yongjun Liu,Na Zhang +1 more
TL;DR: GdNPs offers potential advantages that change the usual cancer therapy from separating diagnosis and treatment to theranostic approach, and mainly factors that affect the preparation process, such as GdNP materials, the loading of Gd/drugs in GdNBP, and the passive and active targeting strategies were discussed.
References
More filters
Journal Article
Long-Circulating and Target-Specific Nanoparticles: Theory to Practice
TL;DR: The surface mechanisms, which affords red blood cells long-circulatory lives and the ability of specific microorganisms to evade macrophage recognition, are explored and the rational approaches in the design as well as the biological performance of such constructs are assessed.
Journal ArticleDOI
Drug Resistance and the Solid Tumor Microenvironment
TL;DR: How the tumor microenvironment may be involved in the resistance of solid tumors to chemotherapy and potential strategies to improve the effectiveness of drug treatment by modifying factors relating to the tumormicroenvironment are described.
Journal ArticleDOI
PKSolver: An add-in program for pharmacokinetic and pharmacodynamic data analysis in Microsoft Excel
TL;DR: The PKSolver provided pharmacokinetic researchers with a fast and easy-to-use tool for routine and basic PK and PD data analysis with a more user-friendly interface and its output could be generated in Microsoft Word in the form of an integrated report.
Journal ArticleDOI
Pluronic block copolymers: evolution of drug delivery concept from inert nanocarriers to biological response modifiers.
TL;DR: These studies suggest that Pluronics have a broad spectrum of biological response modifying activities which make it one of the most potent drug targeting systems available, resulting in a remarkable impact on the emergent field of nanomedicine.
Journal ArticleDOI
Nanotechnology in cancer therapeutics: bioconjugated nanoparticles for drug delivery
TL;DR: The use of bioconjugated nanoparticles for the delivery and targeting of anticancer drugs and imaging contrast agents is discussed.
Related Papers (5)
A New Concept for Macromolecular Therapeutics in Cancer Chemotherapy: Mechanism of Tumoritropic Accumulation of Proteins and the Antitumor Agent Smancs
Yasuhiro Matsumura,Hiroshi Maeda +1 more