PPARγΔ5, a Naturally Occurring Dominant-Negative Splice Isoform, Impairs PPARγ Function and Adipocyte Differentiation.
Marianna Aprile,Simona Cataldi,Maria Rosaria Ambrosio,Vittoria D'Esposito,Koini Lim,Arne Dietrich,Matthias Blüher,David B. Savage,Pietro Formisano,Alfredo Ciccodicola,Valerio Costa +10 more
TLDR
The skipping of exon 5 is reported as a legitimate splicing event generating PPARγΔ5, a previously unidentified naturally occurring truncated isoform ofPPARγ, which lacks the entire ligand-binding domain and mimics PPARG dominant-negative mutated receptors, possibly contributing to adipose tissue dysfunction.About:
This article is published in Cell Reports.The article was published on 2018-11-06 and is currently open access. It has received 53 citations till now. The article focuses on the topics: Adipocyte & Adipose tissue.read more
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Adipose Tissue Dysfunction as Determinant of Obesity-Associated Metabolic Complications
Michele Longo,Federica Zatterale,Federica Zatterale,Jamal Naderi,Jamal Naderi,Luca Parrillo,Luca Parrillo,Pietro Formisano,Pietro Formisano,Gregory Alexander Raciti,Gregory Alexander Raciti,Francesco Beguinot,Francesco Beguinot,Claudia Miele,Claudia Miele +14 more
TL;DR: A better understanding of the mechanisms regulating adipose tissue expansion in obesity is required for the development of future therapeutic approaches in obesity-associated metabolic complications.
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PPARgamma in Metabolism, Immunity, and Cancer: Unified and Diverse Mechanisms of Action.
TL;DR: The proliferation-activated receptor γ (PPARγ), a member of the nuclear receptor superfamily, is one of the most extensively studied ligand-inducible transcription factors as mentioned in this paper.
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Gene-gene and gene-environment interactions in lipodystrophy: Lessons learned from natural PPARγ mutants
TL;DR: Several gene-gene and gene-environment factors and mechanisms that are critical for adequate PPARγ expression and activity in AT are presented and how these interactions potentially contribute to the observed spectrum of FPLD3 phenotypes are discussed.
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HNF4α Combinatorial Isoform Heterodimers Activate Distinct Gene Targets that Differ from Their Corresponding Homodimers.
TL;DR: It is shown that inflammation and immune pathway genes are differentially regulated in an isoform-dependent manner, confirming that each isoform homodimer preferentially regulates a subset of HNF4α targets.
Journal ArticleDOI
Nuclear receptors in podocyte biology and glomerular disease.
TL;DR: The authors focus on the roles of nuclear receptors in podocyte biology and non-diabetic glomerular disease as well as their potential as therapeutic targets.
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