Processing of Mgm1 by the Rhomboid-type Protease Pcp1 Is Required for Maintenance of Mitochondrial Morphology and of Mitochondrial DNA
TLDR
Wong et al. as discussed by the authors characterized the mitochondrial dynamin-like protein Mgm1 and its orthologs in two forms of different lengths, i.e., the large isoform (l-Mgm1) contains an N-terminal putative transmembrane segment that is absent in the short isoform.About:
This article is published in Journal of Biological Chemistry.The article was published on 2003-07-25 and is currently open access. It has received 370 citations till now. The article focuses on the topics: Mitochondrial fission & Mitochondrial inner membrane fusion.read more
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Mitochondrial fusion and fission in cell life and death
TL;DR: The core components of the evolutionarily conserved fusion and fission machineries have now been identified, and mechanistic studies have revealed the first secrets of the complex processes that govern fusion andfission of a double membrane-bound organelle.
Journal ArticleDOI
OPA1 Controls Apoptotic Cristae Remodeling Independently from Mitochondrial Fusion
Christian Frezza,Sara Cipolat,Olga Martins de Brito,Massimo Micaroni,Galina V. Beznoussenko,Tomasz Rudka,Davide Bartoli,Roman S. Polishuck,Nika N. Danial,Bart De Strooper,Luca Scorrano +10 more
TL;DR: Evidence is provided that Optic Atrophy 1 (OPA1), a profusion dynamin-related protein of the inner mitochondrial membrane mutated in dominant optic atrophy, protects from apoptosis by preventing cytochrome c release independently from mitochondrial fusion.
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The dynamin superfamily: universal membrane tubulation and fission molecules?
TL;DR: It is proposed that a common mechanism leading to membrane tubulation and/or fission could encompass their many varied functions.
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Translocation of proteins into mitochondria.
TL;DR: This review summarizes the present knowledge on the import and sorting of mitochondrial precursor proteins, with a special emphasis on unresolved questions and topics of current research.
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Disruption of Fusion Results in Mitochondrial Heterogeneity and Dysfunction
TL;DR: It is shown that cells with targeted null mutations in Mfn1 or Mfn2 retained low levels of mitochondrial fusion and escaped major cellular dysfunction, suggesting a requirement for mitochondrial fusion, beyond maintenance of organelle morphology.
References
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Engineering hybrid genes without the use of restriction enzymes: gene splicing by overlap extension.
TL;DR: Gene splicing by overlap extension is a new approach for recombining DNA molecules at precise junctions irrespective of nucleotide sequences at the recombination site and without the use of restriction endonucleases or ligase.
Book
Methods in yeast genetics : a Cold Spring Harbor Laboratory course manual
TL;DR: Experiments: looking at yeast cells isolation and characterization of auxotrophic, temperature-sensitive and UV-sensitive mutants meiotic mapping mitotic recombination and random spore analysis transformation of yeast synthetic lethal mutants gene replacement isolation of ras2 suppressors manipulating cell types isolating mutants by insertional mutagenesis two-hybrid protein interaction method.
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Methods in Yeast Genetics: A Laboratory Course Manual
TL;DR: An intensive course in yeast genetics has been held at Cold Spring Harbor Laboratory for some years, and the course manual reflects its content and scope as discussed by the authors, with a focus on yeast genetics.
Journal ArticleDOI
Methods in Yeast Genetics — A Laboratory Course Manual. 198 S., G. Kunze. Abb. Cold Spring Harbor Laboratory (1990)
D.M. Rose,F. Winston,P Hieter +2 more
TL;DR: An intensive course in yeast genetics has been held at Cold Spring Harbor Laboratory for some years, and the course manual reflects its content and scope.