Journal ArticleDOI
Protein and amino acid nutrition and metabolism in fish: current knowledge and future needs
Sadasivam Kaushik,Iban Seiliez +1 more
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TLDR
In fish, despite low muscle protein synthesis rates, the efficiency of protein deposition appears to be high, and research on specific signalling pathways involved in protein synthesis and degradation have been initiated to elucidate the reasons for high dietary protein/amino acid supply required and their utilization.Abstract:
Optimising the amino acid supply in tune with the requirements and improving protein utilization for body protein growth with limited impacts on the environment in terms of nutrient loads is a generic imperative in all animal production systems. With the continued high annual growth rate reported for global aquaculture, our commitments should be to make sure that this growth is indeed reflected in provision of protein of high biological value for humans. The limited availability of fish meal has led to some concerted efforts in fish meal replacement, analysing all possible physiological or metabolic consequences. The rising costs of plant feedstuffs make it necessary to strengthen our basic knowledge on amino acid availability and utilization. Regulation of muscle protein accretion has great significance with strong practical implications. In fish, despite low muscle protein synthesis rates, the efficiency of protein deposition appears to be high. Exploratory studies on amino acid flux, inter-organ distribution and particularly of muscle protein synthesis, growth and degradation and the underlying mechanisms as affected by dietary factors are warranted. Research on specific signalling pathways involved in protein synthesis and degradation have been initiated in order to elucidate the reasons for high dietary protein/amino acid supply required and their utilization.read more
Citations
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Journal ArticleDOI
Beneficial roles of feed additives as immunostimulants in aquaculture: a review
Journal ArticleDOI
Mineral requirements of fish: a systematic review
P. Antony Jesu Prabhu,P. Antony Jesu Prabhu,P. Antony Jesu Prabhu,Johan W. Schrama,Sadasivam Kaushik +4 more
TL;DR: In this article, a meta-analysis of literature data on mineral and trace element requirements of fish was performed with the major objectives of identifying appropriate response criteria and the factors affecting the minimal dietary inclusion levels.
Journal ArticleDOI
Insect meals in fish nutrition
Silvia Nogales-Mérida,Paola Gobbi,Damian Józefiak,Jan Mazurkiewicz,Krzysztof Dudek,Mateusz Rawski,Bartosz Kierończyk,Agata Józefiak +7 more
TL;DR: Generally, insect meals have higher indispensable amino acid contents than other meal types, with contents closely related to those in fish meal, and these values are higher than those reported for other animal and plant meals.
Journal ArticleDOI
Thoughts for the Future of Aquaculture Nutrition: Realigning Perspectives to Reflect Contemporary Issues Related to Judicious Use of Marine Resources in Aquafeeds
Journal ArticleDOI
Evaluation of Candida utilis, Kluyveromyces marxianus and Saccharomyces cerevisiae yeasts as protein sources in diets for Atlantic salmon (Salmo salar)
TL;DR: Feeding moderate levels of S. cerevisiae reduced growth performance and nutrient utilization, while C. utilis and K. marxianus were shown to be promising protein sources in diets for Atlantic salmon, capable of replacing 40% of the protein from high-quality fishmeal without adversely affecting growth performance, digestibility or nutrient retention.
References
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Journal ArticleDOI
The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1
Yasemin Sancak,Timothy R. Peterson,Yoav D. Shaul,Robert A. Lindquist,Carson C. Thoreen,Liron Bar-Peled,David M. Sabatini,David M. Sabatini +7 more
TL;DR: It is found that the Rag proteins—a family of four related small guanosine triphosphatases (GTPases)—interact with mTORC1 in an amino acid–sensitive manner and are necessary for the activation of the m TORC1 pathway by amino acids.
Journal ArticleDOI
Antinutritional factors present in plant-derived alternate fish feed ingredients and their effects in fish
TL;DR: The use of plant-derived materials such as legume seeds, different types of oilseed cake, leaf meals, leaf protein concentrates, and root tuber meals as fish feed ingredients is limited by the presence of a wide variety of antinutritional substances.
Journal ArticleDOI
The 26S Proteasome: A Molecular Machine Designed for Controlled Proteolysis
TL;DR: In eukaryotic cells, most proteins in the cytosol and nucleus are degraded via the ubiquitin-proteasome pathway, and the 26S proteasome is a 2-MDa molecular machine built from approximately 31 different subunits, which catalyzes protein degradation.
Journal ArticleDOI
Expanding the utilization of sustainable plant products in aquafeeds: a review
Delbert M. Gatlin,Frederic T. Barrows,Paul B. Brown,Konrad Dabrowski,T. Gibson Gaylord,Ronald W. Hardy,Eliot M. Herman,Gongshe Hu,Åshild Krogdahl,Richard Nelson,Kenneth E. Overturf,Michael B. Rust,Wendy M. Sealey,Denise I. Skonberg,Edward Souza,David A.J. Stone,Rich Wilson,Eve Syrkin Wurtele +17 more
TL;DR: This document reviews various plant feedstuis, which currently are or potentially may be incorporated into aquafeeds to support the sustainable production of various ¢sh species in aquaculture and strategies and techniques to optimize the nutritional composition and limit potentially adverse eiects of bioactive compounds are described.
Journal ArticleDOI
The ubiquitin-proteasome proteolytic pathway
TL;DR: Two studies clearly demonstrate that the ubiquitin-proteasome system is involved not only in complete destruction of its protein substrates, but also in limited proteolysis and posttranslational processing in which biologically active peptides or fragments are generated.
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