Pulmonary Megakaryocytes in Coronavirus Disease 2019 (COVID-19): Roles in Thrombi and Fibrosis
Jecko Thachil,Ton Lisman +1 more
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Este es el reporte de situación COVID-19 Colombia No 130 - 27 de agosto de 2020.Citations
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COVID-19 immune features revealed by a large-scale single-cell transcriptome atlas.
Xianwen Ren,Wen Wen,Xiaoying Fan,Wenhong Hou,Bin Su,Pengfei Cai,Jiesheng Li,Yang Liu,Fei Tang,Fan Zhang,Yu Yang,Jiangping He,Wenji Ma,Jingjing He,Pingping Wang,Qiqi Cao,Fangjin Chen,Yuqing Chen,Xuelian Cheng,Guohong Deng,Xilong Deng,Wenyu Ding,Wenyu Ding,Yingmei Feng,Rui Gan,Chuang Guo,Weiqiang Guo,Shuai He,Chen Jiang,Juanran Liang,Yimin Li,Jun Lin,Yun Ling,Haofei Liu,Jianwei Liu,Nianping Liu,Shu-Qiang Liu,Meng Luo,Qiang Ma,Qibing Song,Wujianan Sun,Gaoxiang Wang,Feng Wang,Ying Wang,Xiaofeng Wen,Qian Wu,Gang Xu,Xiaowei Xie,Xinxin Xiong,Xudong Xing,Hao Xu,Chonghai Yin,Dongdong Yu,Kezhuo Yu,Jin Yuan,Biao Zhang,Peipei Zhang,Peipei Zhang,Peipei Zhang,Tong Zhang,Jincun Zhao,Peidong Zhao,Jianfeng Zhou,Wei Zhou,Sujuan Zhong,Xiaosong Zhong,Shuye Zhang,Lin Zhu,Ping Zhu,Bin Zou,Jiahua Zou,Zengtao Zuo,Fan Bai,Xi Huang,Penghui Zhou,Qinghua Jiang,Zhiwei Huang,Jin-Xin Bei,Lai Wei,Xiu-Wu Bian,Xiu-Wu Bian,Xindong Liu,Xindong Liu,Tao Cheng,Xiangpan Li,Pingsen Zhao,Fu-Sheng Wang,Hongyang Wang,Bing Su,Zheng Zhang,Kun Qu,Xiaoqun Wang,Jiekai Chen,Ronghua Jin,Zemin Zhang +94 more
TL;DR: In this article, the authors applied single-cell RNA sequencing to 284 samples from 196 COVID-19 patients and controls and created a comprehensive immune landscape with 1.46 million cells.
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Platelet Biogenesis in the Lung Circulation
TL;DR: It is concluded that the lung has significant hematopoietic potential including being a major site of platelet biogenesis and orthotopic, single-lung transplantation experiments into thrombocytopenic and hematOPoietIC progenitor-deficient animals revealed that peripheral blood platelet counts and bone marrow hematopolietic progenitors could be fully reconstituted by the lung transplant procedure.
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COVID-19 Immunobiology: Lessons Learned, New Questions Arise.
Aimilios Kaklamanos,Konstantinos Belogiannis,Panagiotis Skendros,Vassilis G. Gorgoulis,Panayiotis G. Vlachoyiannopoulos,Athanasios G. Tzioufas +5 more
TL;DR: In this article, the authors found that COVID-19 pathophysiology is mainly driven by a spatiotemporal immune deregulation, with the contribution of immune and cellular stress-response mediators (like cellular senescence or uncontrolled inflammatory cell death).
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Maintaining Hemostasis and Preventing Thrombosis in Coronavirus Disease 2019 (COVID-19): Part II
TL;DR: The issue starts with themes around thrombosis, given this is a major feature in patients with severe COVID-19, and the first contribution is from Di Minno et al, who provide an updated meta-analysis of literature studies around COVID19 and venous thromboembolism (VTE), thus providing the backdrop to a major theme of this series.
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Inflammatory Mediators of Platelet Activation: Focus on Atherosclerosis and COVID-19.
Panagiotis Theofilis,Marios Sagris,Alexios S. Antonopoulos,Evangelos Oikonomou,Costas Tsioufis,Dimitris Tousoulis +5 more
TL;DR: In this paper, the impact of inflammation on platelet activation in atherosclerosis has been investigated and the role of pro-inflammatory cytokines has also been highlighted, such as platelet factor-4, myeloperoxidase, and platelet-derived mediators.
References
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Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study
Nanshan Chen,Min Zhou,Xuan Dong,Jie-Ming Qu,Fengyun Gong,Yang Han,Yang Qiu,Jingli Wang,Ying Liu,Yuan Wei,Jia'an Xia,Ting Yu,Xinxin Zhang,Li Zhang +13 more
TL;DR: Characteristics of patients who died were in line with the MuLBSTA score, an early warning model for predicting mortality in viral pneumonia, and further investigation is needed to explore the applicability of the Mu LBSTA scores in predicting the risk of mortality in 2019-nCoV infection.
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Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19.
Maximilian Ackermann,Stijn E. Verleden,Mark Kuehnel,Axel Haverich,Tobias Welte,Florian Laenger,Arno Vanstapel,Christopher Werlein,Helge Stark,Alexandar Tzankov,William W. Li,Vincent W. Li,Steven J. Mentzer,Danny Jonigk +13 more
TL;DR: In this small series, vascular angiogenesis distinguished the pulmonary pathobiology of Covid-19 from that of equally severe influenza virus infection.
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Cellular and molecular mechanisms of fibrosis.
TL;DR: Current understanding of the cellular and molecular mechanisms of fibrogenesis is explored and components of the renin–angiotensin–aldosterone system (ANG II) have been identified as important regulators of fibrosis and are being investigated as potential targets of antifibrotic drugs.
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Pulmonary and cardiac pathology in African American patients with COVID-19: an autopsy series from New Orleans.
Sharon E. Fox,Aibek Akmatbekov,Jack L. Harbert,Guang Li,J. Quincy Brown,Richard S. Vander Heide +5 more
TL;DR: Key pathological states, including thrombotic and microangiopathic pathology in the lungs, that contributed to death in patients with severe COVID-19 and decompensation in this demographic are identified and management of these patients should include treatment to target these pathological mechanisms.
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The lung is a site of platelet biogenesis and a reservoir for haematopoietic progenitors
Emma Lefrançais,Guadalupe Ortiz-Muñoz,Axelle Caudrillier,Beñat Mallavia,Fengchun Liu,David M. Sayah,Emily E. Thornton,Mark B. Headley,Tovo David,Shaun R. Coughlin,Matthew F. Krummel,Andrew D. Leavitt,Emmanuelle Passegué,Mark R. Looney +13 more
TL;DR: The lungs are identified as a primary site of terminal platelet production and an organ with considerable haematopoietic potential.