Radiotherapy plus chemotherapy with or without surgical resection for stage III non-small-cell lung cancer: a phase III randomised controlled trial
Kathy S. Albain,R. Suzanne Swann,Valerie W. Rusch,Andrew T. Turrisi,Frances A. Shepherd,Colum Smith,Yuhchyau Chen,Robert B. Livingston,Richard H. Feins,David R. Gandara,Willard A Fry,Gail Darling,David H. Johnson,Mark R. Green,Robert C. Miller,Joanne Ley,Willliam T Sause,James D. Cox +17 more
TLDR
The primary endpoint was overall survival (OS) and an exploratory analysis, OS was improved for patients who underwent lobectomy, but not pneumonectomy, versus chemotherapy plus radiotherapy, compared with standard concurrent chemotherapy and definitive radiotherapy without resection.About:
This article is published in The Lancet.The article was published on 2009-08-01 and is currently open access. It has received 1202 citations till now. The article focuses on the topics: Induction chemotherapy & Survival rate.read more
Citations
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NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines
TL;DR: Lymphedema is a common complication after treatment for breast cancer and factors associated with increased risk of lymphedEMA include extent of axillary surgery, axillary radiation, infection, and patient obesity.
Journal ArticleDOI
Early and locally advanced non-small-cell lung cancer (NSCLC): ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
Johan Vansteenkiste,Dirk De Ruysscher,Wilfried Eberhardt,Eric Lim,Suresh Senan,Enriqueta Felip,Solange Peters +6 more
TL;DR: The Clatterbridge Cancer Centre and Liverpool Heart and Chest Hospital, Liverpool; University of Aberdeen, Aberdeen, UK; Center for Medical Imaging, University of Groningen, Groningen; Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands; and Department of Thoracic Surgery, University Hospitals of Leicester NHS Trust, Leicester, UK.
Journal ArticleDOI
Management of non-small-cell lung cancer: recent developments.
TL;DR: The evolution of lung cancer staging towards more non-invasive, endoscopy-based, and image-based methods, and the development of stage-adapted treatment is discussed, with an emphasis on targeted therapies based on the assumption that a treatable driver mutation or gene rearrangement is present within the tumour.
Journal ArticleDOI
In situ sprayed bioresponsive immunotherapeutic gel for post-surgical cancer treatment
Qian Chen,Qian Chen,Chao Wang,Xudong Zhang,Guojun Chen,Quanyin Hu,Quanyin Hu,Hongjun Li,Jinqiang Wang,Di Wen,Yuqi Zhang,Yifei Lu,Yifei Lu,Guang Yang,Chen Jiang,Jun Wang,Gianpietro Dotti,Zhen Gu +17 more
TL;DR: The findings indicate that the immunotherapeutic fibrin gel ‘awakens’ the host innate and adaptive immune systems to inhibit both local tumour recurrence post surgery and potential metastatic spread.
Journal ArticleDOI
Non–Small Cell Lung Cancer
David S. Ettinger,Wallace Akerley,Gerold Bepler,Andrew C. Chang,Richard T. Cheney,Lucian R. Chirieac,Thomas A. D'Amico,Todd L. Demmy,Steven J. Feigenberg,Robert A. Figlin,Ramaswamy Govindan,Frederic W. Grannis,Thierry Jahan,Mohammad Jahanzeb,Anne Kessinger,Ritsuko Komaki,Mark G. Kris,Corey J. Langer,Quynh-Thu Le,Renato G. Martins,Gregory A. Otterson,Jyoti D. Patel,Francisco Robert,David J. Sugarbaker,Douglas E. Wood +24 more
TL;DR: In 2010, approximately 222,520 new cases of lung or bronchial cancer will be diagnosed in the USA, and 157,300 patients are expected to die of this disease as discussed by the authors.
References
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Book ChapterDOI
Nonparametric Estimation from Incomplete Observations
Edward L. Kaplan,Paul Meier +1 more
TL;DR: In this article, the product-limit (PL) estimator was proposed to estimate the proportion of items in the population whose lifetimes would exceed t (in the absence of such losses), without making any assumption about the form of the function P(t).
Regression models and life tables (with discussion
TL;DR: The drum mallets disclosed in this article are adjustable, by the percussion player, as to balance, overall weight, head characteristics and tone production of the mallet, whereby the adjustment can be readily obtained.
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Phase III Study of Concurrent Versus Sequential Thoracic Radiotherapy in Combination With Mitomycin, Vindesine, and Cisplatin in Unresectable Stage III Non–Small-Cell Lung Cancer
Kiyoyuki Furuse,Masahiro Fukuoka,Masaaki Kawahara,Hideki Nishikawa,Y. Takada,Shinzoh Kudoh,Nobuyuki Katagami,Yutaka Ariyoshi +7 more
TL;DR: In selected patients with unresectable stage III NSCLC, the concurrent approach yields a significantly increased response rate and enhanced median survival duration when compared with the sequential approach.
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A randomized trial comparing preoperative chemotherapy plus surgery with surgery alone in patients with non-small-cell lung cancer.
Rafael Rosell,José Gómez-Codina,Carlos Camps,José Maestre,J Padille,Antonio Canto,Jose Luis Mate,S Li,J. Roig,A Olazábal +9 more
TL;DR: Preoperative chemotherapy increases the median survival in patients with non-small-cell lung cancer, and the prevalence of mutated K-ras oncogenes was 15 percent among the patients receiving preoperative chemotherapy and 42 percent among those treated with surgery alone.
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A randomized trial of induction chemotherapy plus high-dose radiation versus radiation alone in stage III non-small-cell lung cancer.
Robert O. Dillman,Stephen L. Seagren,Kathleen J. Propert,Julio Guerra,Walter L. Eaton,Michael C. Perry,Robert W. Carey,Emil Frei,Mark R. Green +8 more
TL;DR: In patients with Stage III non-small-cell lung cancer, induction chemotherapy with cisplatin and vinblastine before radiation significantly improves median survival and doubles the number of long-term survivors, as compared with radiation therapy alone.
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Anne Auperin,Cécile Le Péchoux,Estelle Rolland,Walter J. Curran,Kiyoyuki Furuse,Pierre Fournel,José Belderbos,Gerald H. Clamon,Hakki Cuneyt Ulutin,Rebecca Paulus,Takeharu Yamanaka,Marie-Cecile Bozonnat,Apollonia L.J. Uitterhoeve,Xiaofei Wang,Lesley A. Stewart,Rodrigo Arriagada,Sarah Burdett,Jean-Pierre Pignon +17 more