Recent advances in the molecular pathophysiology of atrial fibrillation
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TLDR
The ways in which cardiac disease states, extracardiac factors, and abnormal genetic control lead to the arrhythmia are discussed, including the potential therapeutic implications that might arise from an improved mechanistic understanding.Abstract:
Atrial fibrillation (AF) is an extremely common cardiac rhythm disorder that causes substantial morbidity and contributes to mortality. The mechanisms underlying AF are complex, involving both increased spontaneous ectopic firing of atrial cells and impulse reentry through atrial tissue. Over the past ten years, there has been enormous progress in understanding the underlying molecular pathobiology. This article reviews the basic mechanisms and molecular processes causing AF. We discuss the ways in which cardiac disease states, extracardiac factors, and abnormal genetic control lead to the arrhythmia. We conclude with a discussion of the potential therapeutic implications that might arise from an improved mechanistic understanding.read more
Citations
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Journal ArticleDOI
Autophagy exacerbates electrical remodeling in atrial fibrillation by ubiquitin-dependent degradation of L-type calcium channel
Yue Yuan,Jing Zhao,Yongtai Gong,Dingyu Wang,Xiaoyu Wang,Fengxiang Yun,Zhaorui Liu,Song Zhang,Wenpeng Li,Xinbo Zhao,Li Sun,Li Sheng,Zhenwei Pan,Yue Li,Yue Li +14 more
TL;DR: It is suggested that autophagy induces atrial electrical remodeling via ubiquitin-dependent selective degradation of Cav1.2 and provide a novel and promising strategy for preventing AF development.
Journal ArticleDOI
VCAM-1 as a predictor biomarker in cardiovascular disease
Mayarling Francisca Troncoso,Jafet Ortiz-Quintero,Valeria Garrido-Moreno,Fernanda Sanhueza-Olivares,Alejandra Guerrero-Moncayo,Mario Chiong,Pablo Castro,Lorena García,Luigi Gabrielli,Ramón Corbalán,Luis Garrido-Olivares,Sergio Lavandero,Sergio Lavandero +12 more
TL;DR: In this article, the role of sVCAM-1 as a biomarker to predict the occurrence, development, and preservation of cardiovascular disease was discussed, where the authors also discussed the importance of the vascular cellular adhesion molecule (VCAM) in the adhesion and transmigration of leukocytes.
Journal ArticleDOI
Impaired Na⁺-dependent regulation of acetylcholine-activated inward-rectifier K⁺ current modulates action potential rate dependence in patients with chronic atrial fibrillation.
Niels Voigt,Niels Voigt,Jordi Heijman,Anne Trausch,Elisa Mintert-Jancke,Lutz Pott,Ursula Ravens,Dobromir Dobrev,Dobromir Dobrev +8 more
TL;DR: In this article, the effect of [Na+]i-dependent regulation of inward-rectifier K+ currents on APD in human atrial myocytes is investigated and shown to be a potential mechanism contributing to the blunted APD rate dependence in patients with chronic atrial fibrillation.
Journal ArticleDOI
Molecular Mechanisms Underlying Urate-Induced Enhancement of Kv1.5 Channel Expression in HL-1 Atrial Myocytes
Nani Maharani,Ya Kuang Ting,Jidong Cheng,Akira Hasegawa,Yasutaka Kurata,Peili Li,Yuji Nakayama,Haruaki Ninomiya,Nobuhito Ikeda,Kumi Morikawa,Kazuhiro Yamamoto,Naomasa Makita,Takeshi Yamashita,Yasuaki Shirayoshi,Ichiro Hisatome +14 more
TL;DR: Intracellular urate taken up by UATs enhanced Kv1.5 protein expression and function in HL-1 atrial myocytes, which could be attributable to ERK phosphorylation and oxidative stress derived from nicotinamide adenine dinucleotide phosphate (NADPH)-oxidase.
Journal ArticleDOI
Atrial Fibrillation-Mediated Upregulation of miR-30d Regulates Myocardial Electrical Remodeling of the G-Protein-Gated K+ Channel, IK.ACh
Masaki Morishima,Eriko Iwata,Chisato Nakada,Yoshiyuki Tsukamoto,Hiroki Takanari,Shinji Miyamoto,Masatsugu Moriyama,Katsushige Ono +7 more
TL;DR: MiR-30d was significantly upregulated in cardiomyocytes from AF patients, whereas the mRNA and protein levels ofCACNA1C/Cav1.2 andKCNJ3/Kir3.1, postulated targets of miR- 30d, were markedly reduced, revealing a novel post-transcriptional regulation ofIK.ACh.
References
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Journal ArticleDOI
Spontaneous Initiation of Atrial Fibrillation by Ectopic Beats Originating in the Pulmonary Veins
Michel Haïssaguerre,Pierre Jaïs,D. C. Shah,Atsushi Takahashi,Mélèze Hocini,G Quiniou,S. Garrigue,A Le Mouroux,P Le Métayer,Jacques Clementy +9 more
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Atrial Fibrillation Begets Atrial Fibrillation A Study in Awake Chronically Instrumented Goats
TL;DR: Artificial maintenance of AF leads to a marked shortening of AERP, a reversion of its physiological rate adaptation, and an increase in rate, inducibility and stability of AF.
Journal ArticleDOI
Secular Trends in Incidence of Atrial Fibrillation in Olmsted County, Minnesota, 1980 to 2000, and Implications on the Projections for Future Prevalence
Yoko Miyasaka,Marion E. Barnes,Bernard J. Gersh,Stephen S. Cha,Kent R. Bailey,Walter P. Abhayaratna,James B. Seward,Teresa S.M. Tsang +7 more
TL;DR: The age-adjusted incidence of AF increased significantly in Olmsted County during 1980 to 2000 and the projected number of persons with AF for the United States will exceed 10 million by 2050, underscoring the urgent need for primary prevention strategies against AF development.
Journal ArticleDOI
MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts
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Journal ArticleDOI
Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis
Eva van Rooij,Lillian B. Sutherland,Jeffrey E. Thatcher,J. Michael DiMaio,R. Haris Naseem,William S. Marshall,Joseph A. Hill,Eric N. Olson +7 more
TL;DR: It is concluded that miR-29 acts as a regulator of cardiac fibrosis and represents a potential therapeutic target for tissue fibrosis in general.