Recent advances in the molecular pathophysiology of atrial fibrillation
Reads0
Chats0
TLDR
The ways in which cardiac disease states, extracardiac factors, and abnormal genetic control lead to the arrhythmia are discussed, including the potential therapeutic implications that might arise from an improved mechanistic understanding.Abstract:
Atrial fibrillation (AF) is an extremely common cardiac rhythm disorder that causes substantial morbidity and contributes to mortality. The mechanisms underlying AF are complex, involving both increased spontaneous ectopic firing of atrial cells and impulse reentry through atrial tissue. Over the past ten years, there has been enormous progress in understanding the underlying molecular pathobiology. This article reviews the basic mechanisms and molecular processes causing AF. We discuss the ways in which cardiac disease states, extracardiac factors, and abnormal genetic control lead to the arrhythmia. We conclude with a discussion of the potential therapeutic implications that might arise from an improved mechanistic understanding.read more
Citations
More filters
Atrial fi brillation in the presence and absence of heart failure enhances expression of genes involved in cardiomyocyte structure, conduction properties, fi brosis, in fl ammation, and endothelial dysfunction
Stef Zeemering,Aaron Isaacs,Joris Winters,Bart Maesen,Elham Bidar,Christina Dimopoulou,Eduard Guasch,Montserrat Batlle,Doreen Haase,Stéphane N. Hatem,M Kara,Lluís Mont,Moritz F. Sinner,Reza Wakili,Jos G. Maessen,Harry J.G.M. Crijns,Larissa Fabritz,Paulus Kirchhof,Monika Stoll,Ulrich Schotten +19 more
TL;DR: Interestingly, no consistent transcriptional changes were associated with paroxysmal AF, suggesting that AF-induced changes in gene expression predominate other changes.
Journal ArticleDOI
Blockade of SK4 channels suppresses atrial fibrillation by attenuating atrial fibrosis in canines with prolonged atrial pacing
Youcheng Wang,Yajun Yao,Yazhe Ma,Shanqing He,Mei Yang,Zhen Cao,Shiwen Liudi,Yuntao Fu,Huiyu Chen,Xin Wang,Congxin Huang,Qingyan Zhao +11 more
TL;DR: In this paper , the authors investigated the role of SK4 in atrial fibrillation (AF) maintenance and found that SK4 blockade suppressed AF by attenuating cardiac fibroblast activity and atrial fibrosis, which was realized through a decrease in fibrogenic factors and inhibition of fibrotic signaling pathways.
Journal ArticleDOI
Increased body mass index, age, and left atrial size are associated with altered intracardiac atrial electrograms in persistent atrial fibrillation patients.
TL;DR: In this paper, the authors evaluated whether atrial fibrillation patients with increased BMI, age, and left atrial (LA) size have altered intracardiac electrogram (EGM) morphology.
Journal ArticleDOI
Response to: "The emerging role of hybrid ablation for ablation" by Spartialis M. et al.
Posted ContentDOI
Pre-Existing Cardiovascular Disease Increases Risk of Atrial Arrhythmia in Cancer Patients Treated with Ibrutinib
Juan Carlo Avalon,Jacob Fuqua,Tyler Miller,Seth Deskins,Chelby Wakefield,Austin King,Sonya Inderbitzin-Brooks,Christopher Bianco,Lauren Veltri,Wei Fang,Michael Craig,Abraham S. Kanate,Kelly G. Ross,Midhun Malla,Brijesh Patel +14 more
TL;DR: Pre-existing cardiovascular disease was associated with significantly higher rates of atrial arrhythmia and mortality in patients with hematological malignancies managed with ibrutinib.
References
More filters
Journal ArticleDOI
Spontaneous Initiation of Atrial Fibrillation by Ectopic Beats Originating in the Pulmonary Veins
Michel Haïssaguerre,Pierre Jaïs,D. C. Shah,Atsushi Takahashi,Mélèze Hocini,G Quiniou,S. Garrigue,A Le Mouroux,P Le Métayer,Jacques Clementy +9 more
TL;DR: The pulmonary veins are an important source of ectopic beats, initiating frequent paroxysms of atrial fibrillation and these foci respond to treatment with radio-frequency ablation.
Journal ArticleDOI
Atrial Fibrillation Begets Atrial Fibrillation A Study in Awake Chronically Instrumented Goats
TL;DR: Artificial maintenance of AF leads to a marked shortening of AERP, a reversion of its physiological rate adaptation, and an increase in rate, inducibility and stability of AF.
Journal ArticleDOI
Secular Trends in Incidence of Atrial Fibrillation in Olmsted County, Minnesota, 1980 to 2000, and Implications on the Projections for Future Prevalence
Yoko Miyasaka,Marion E. Barnes,Bernard J. Gersh,Stephen S. Cha,Kent R. Bailey,Walter P. Abhayaratna,James B. Seward,Teresa S.M. Tsang +7 more
TL;DR: The age-adjusted incidence of AF increased significantly in Olmsted County during 1980 to 2000 and the projected number of persons with AF for the United States will exceed 10 million by 2050, underscoring the urgent need for primary prevention strategies against AF development.
Journal ArticleDOI
MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts
Thomas Thum,Carina Gross,Jan Fiedler,Thomas Fischer,Stephan Kissler,Markus Bussen,Paolo Galuppo,Steffen Just,Wolfgang Rottbauer,Stefan Frantz,Mirco Castoldi,Jürgen Soutschek,Victor Koteliansky,Andreas Rosenwald,M. Albert Basson,Jonathan D. Licht,John T. R. Pena,Sara H. Rouhanifard,Martina U. Muckenthaler,Thomas Tuschl,Gail R. Martin,Johann Bauersachs,Stefan Engelhardt,Stefan Engelhardt +23 more
TL;DR: It is shown that microRNA-21 regulates the ERK–MAP kinase signalling pathway in cardiac fibroblasts, which has impacts on global cardiac structure and function and confirms miR-21 as a disease target in heart failure and establishes the therapeutic efficacy of microRNA therapeutic intervention in a cardiovascular disease setting.
Journal ArticleDOI
Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis
Eva van Rooij,Lillian B. Sutherland,Jeffrey E. Thatcher,J. Michael DiMaio,R. Haris Naseem,William S. Marshall,Joseph A. Hill,Eric N. Olson +7 more
TL;DR: It is concluded that miR-29 acts as a regulator of cardiac fibrosis and represents a potential therapeutic target for tissue fibrosis in general.