Recent advances in the molecular pathophysiology of atrial fibrillation
Reads0
Chats0
TLDR
The ways in which cardiac disease states, extracardiac factors, and abnormal genetic control lead to the arrhythmia are discussed, including the potential therapeutic implications that might arise from an improved mechanistic understanding.Abstract:
Atrial fibrillation (AF) is an extremely common cardiac rhythm disorder that causes substantial morbidity and contributes to mortality. The mechanisms underlying AF are complex, involving both increased spontaneous ectopic firing of atrial cells and impulse reentry through atrial tissue. Over the past ten years, there has been enormous progress in understanding the underlying molecular pathobiology. This article reviews the basic mechanisms and molecular processes causing AF. We discuss the ways in which cardiac disease states, extracardiac factors, and abnormal genetic control lead to the arrhythmia. We conclude with a discussion of the potential therapeutic implications that might arise from an improved mechanistic understanding.read more
Citations
More filters
Journal ArticleDOI
The State of the Art: Atrial Fibrillation Epidemiology, Prevention, and Treatment.
Daniel P. Morin,Daniel P. Morin,Michael L. Bernard,Christopher Madias,Paul A. Rogers,Sudarone Thihalolipavan,N.A. Mark Estes +6 more
TL;DR: This "state-of-the-art" review provides a comprehensive update on the understanding of AF in the world today, contemporary therapeutic options, and directions of ongoing and future study.
Journal ArticleDOI
Expert consensus document: Defining the major health modifiers causing atrial fibrillation: a roadmap to underpin personalized prevention and treatment
Larissa Fabritz,Eduard Guasch,Charalambos Antoniades,Isabel Bardinet,Gerlinde Benninger,Timothy R. Betts,Eva Brand,Günter Breithardt,Gabriela Bucklar-Suchankova,A. John Camm,A. John Camm,David Cartlidge,Barbara Casadei,Winnie Chua,Harry J.G.M. Crijns,Jon Deeks,Stéphane N. Hatem,Françoise Hidden-Lucet,Stefan Kääb,Nikos Maniadakis,Stephan Martin,Lluís Mont,Holger Reinecke,Moritz F. Sinner,Ulrich Schotten,Taunton R. Southwood,Monika Stoll,Panos E. Vardas,Reza Wakili,Andrew West,André Ziegler,Paulus Kirchhof +31 more
TL;DR: A roadmap to develop a set of clinical markers that reflect the major causes of AF in patients is proposed to transform the insights into the mechanisms causing AF into a format that can underpin future personalized strategies to prevent and treat AF, ultimately informing better patient care.
Journal ArticleDOI
Impact of intensive glycemic control on the incidence of atrial fibrillation and associated cardiovascular outcomes in patients with type 2 diabetes mellitus (from the Action to Control Cardiovascular Risk in Diabetes Study).
Omid Fatemi,Omid Fatemi,Eugene Yuriditsky,Eugene Yuriditsky,Costas Tsioufis,Demetrios Tsachris,Timothy R. Morgan,Jan Basile,Jan Basile,Thomas Bigger,William C. Cushman,David C. Goff,Elsayed Z. Soliman,Abraham Thomas,Vasilios Papademetriou +14 more
TL;DR: In this article, the authors evaluated the impact of intensive glycemic control on incident atrial fibrillation (AF) and morbidity and mortality in patients with type 2 diabetes mellitus and incident AF.
Journal ArticleDOI
A roadmap to improve the quality of atrial fibrillation management: proceedings from the fifth Atrial Fibrillation Network/European Heart Rhythm Association consensus conference.
Paulus Kirchhof,Günter Breithardt,Jeroen J. Bax,Gerlinde Benninger,Carina Blomström-Lundqvist,Giuseppe Boriani,Axel Brandes,Helen Brown,Martina Brueckmann,Martina Brueckmann,Hugh Calkins,Melanie Calvert,Vincent M. Christoffels,Harry J.G.M. Crijns,Dobromir Dobrev,Patrick T. Ellinor,Larissa Fabritz,Thomas Fetsch,S. Ben Freedman,Andrea Gerth,Andreas Goette,Eduard Guasch,Guido Hack,Laurent M. Haegeli,Stéphane N. Hatem,Karl Georg Haeusler,Hein Heidbuchel,Jutta Heinrich-Nols,Françoise Hidden-Lucet,Gerd Hindricks,Steen Juul-Möller,Stefan Kääb,Lukas Kappenberger,Stefanie Kespohl,Dipak Kotecha,Deirdre A. Lane,Angelika Leute,Thorsten Lewalter,Ralf Meyer,Lluís Mont,Felix Münzel,Michael Nabauer,Jens Cosedis Nielsen,Michael Oeff,Jonas Oldgren,Ali Oto,Jonathan P. Piccini,Art Pilmeyer,Tatjana S. Potpara,Ursula Ravens,Holger Reinecke,Thomas Rostock,Joerg Rustige,Irene Savelieva,Renate B. Schnabel,Ulrich Schotten,Lars Schwichtenberg,Moritz F. Sinner,Gerhard Steinbeck,Monika Stoll,Monika Stoll,Luigi Tavazzi,Sakis Themistoclakis,Hung-Fat Tse,Isabelle C. Van Gelder,Panagiotis Vardas,Timo Varpula,Alphons Vincent,David J. Werring,Stephan Willems,André Ziegler,Gregory Y.H. Lip,A. John Camm +72 more
TL;DR: This report reports the outcome of the fifth Atrial Fibrillation Network/European Heart Rhythm Association consensus conference in Nice, France, with a focus on learning from 'neighbours' to improve AF care, and a list of priorities for research in AF patients.
Journal ArticleDOI
The small-molecule BGP-15 protects against heart failure and atrial fibrillation in mice
Geeta Sapra,Yow Keat Tham,Nelly Cemerlang,Aya Matsumoto,Helen Kiriazis,Bianca C. Bernardo,Darren C. Henstridge,Jenny Y. Y. Ooi,Lynette Pretorius,Esther J. H. Boey,Lydia Lim,Junichi Sadoshima,Peter J. Meikle,Natalie A. Mellet,Elizabeth A. Woodcock,Silvana Marasco,Tomomi Ueyama,Xiao-Jun Du,Mark A. Febbraio,Julie R. McMullen +19 more
TL;DR: It is demonstrated that BGP-15 and IGF1R can provide protection independent of phosphoinositide 3-kinase-Akt and heat-shock protein 70; signalling mediators often defective in the aged and diseased heart.
References
More filters
Journal ArticleDOI
Spontaneous Initiation of Atrial Fibrillation by Ectopic Beats Originating in the Pulmonary Veins
Michel Haïssaguerre,Pierre Jaïs,D. C. Shah,Atsushi Takahashi,Mélèze Hocini,G Quiniou,S. Garrigue,A Le Mouroux,P Le Métayer,Jacques Clementy +9 more
TL;DR: The pulmonary veins are an important source of ectopic beats, initiating frequent paroxysms of atrial fibrillation and these foci respond to treatment with radio-frequency ablation.
Journal ArticleDOI
Atrial Fibrillation Begets Atrial Fibrillation A Study in Awake Chronically Instrumented Goats
TL;DR: Artificial maintenance of AF leads to a marked shortening of AERP, a reversion of its physiological rate adaptation, and an increase in rate, inducibility and stability of AF.
Journal ArticleDOI
Secular Trends in Incidence of Atrial Fibrillation in Olmsted County, Minnesota, 1980 to 2000, and Implications on the Projections for Future Prevalence
Yoko Miyasaka,Marion E. Barnes,Bernard J. Gersh,Stephen S. Cha,Kent R. Bailey,Walter P. Abhayaratna,James B. Seward,Teresa S.M. Tsang +7 more
TL;DR: The age-adjusted incidence of AF increased significantly in Olmsted County during 1980 to 2000 and the projected number of persons with AF for the United States will exceed 10 million by 2050, underscoring the urgent need for primary prevention strategies against AF development.
Journal ArticleDOI
MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts
Thomas Thum,Carina Gross,Jan Fiedler,Thomas Fischer,Stephan Kissler,Markus Bussen,Paolo Galuppo,Steffen Just,Wolfgang Rottbauer,Stefan Frantz,Mirco Castoldi,Jürgen Soutschek,Victor Koteliansky,Andreas Rosenwald,M. Albert Basson,Jonathan D. Licht,John T. R. Pena,Sara H. Rouhanifard,Martina U. Muckenthaler,Thomas Tuschl,Gail R. Martin,Johann Bauersachs,Stefan Engelhardt,Stefan Engelhardt +23 more
TL;DR: It is shown that microRNA-21 regulates the ERK–MAP kinase signalling pathway in cardiac fibroblasts, which has impacts on global cardiac structure and function and confirms miR-21 as a disease target in heart failure and establishes the therapeutic efficacy of microRNA therapeutic intervention in a cardiovascular disease setting.
Journal ArticleDOI
Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis
Eva van Rooij,Lillian B. Sutherland,Jeffrey E. Thatcher,J. Michael DiMaio,R. Haris Naseem,William S. Marshall,Joseph A. Hill,Eric N. Olson +7 more
TL;DR: It is concluded that miR-29 acts as a regulator of cardiac fibrosis and represents a potential therapeutic target for tissue fibrosis in general.