Recent advances in the molecular pathophysiology of atrial fibrillation
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TLDR
The ways in which cardiac disease states, extracardiac factors, and abnormal genetic control lead to the arrhythmia are discussed, including the potential therapeutic implications that might arise from an improved mechanistic understanding.Abstract:
Atrial fibrillation (AF) is an extremely common cardiac rhythm disorder that causes substantial morbidity and contributes to mortality. The mechanisms underlying AF are complex, involving both increased spontaneous ectopic firing of atrial cells and impulse reentry through atrial tissue. Over the past ten years, there has been enormous progress in understanding the underlying molecular pathobiology. This article reviews the basic mechanisms and molecular processes causing AF. We discuss the ways in which cardiac disease states, extracardiac factors, and abnormal genetic control lead to the arrhythmia. We conclude with a discussion of the potential therapeutic implications that might arise from an improved mechanistic understanding.read more
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Journal ArticleDOI
2014 AHA/ACC/HRS Guideline for the Management of Patients With Atrial Fibrillation: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the Heart Rhythm Society
Craig T. January,L. Samuel Wann,Joseph S. Alpert,Hugh Calkins,Joaquin E. Cigarroa,Joseph C. Cleveland,Jamie B. Conti,Patrick T. Ellinor,Michael D. Ezekowitz,Michael E. Field,Katherine T. Murray,Ralph L. Sacco,William G. Stevenson,Patrick J. Tchou,Cynthia M. Tracy,Clyde W. Yancy +15 more
TL;DR: This document summarizes current research, plans, and recommendations for future research, as well as providing a history of the field and some of the techniques used, currently in use, at the National Institutes of Health.
Journal ArticleDOI
2012 HRS/EHRA/ECAS expert consensus statement on catheter and surgical ablation of atrial fibrillation: Recommendations for patient selection, procedural techniques, patient management and follow-up, definitions, endpoints, and research trial design
Hugh Calkins,Karl-Heinz Kuck,Riccardo Cappato,Josep Brugada,A. John Camm,Shih Ann Chen,Harry J.G.M. Crijns,Ralph J. Damiano,D. Wyn Davies,John P. DiMarco,James R. Edgerton,Kenneth A. Ellenbogen,Michael D. Ezekowitz,David E. Haines,Michel Haïssaguerre,Gerhard Hindricks,Yoshito Iesaka,Warren M. Jackman,José Jalife,Pierre Jaïs,Jonathan M. Kalman,David Keane,Younghoon Kim,Paulus Kirchhof,Paulus Kirchhof,George J. Klein,Hans Kottkamp,Koichiro Kumagai,Bruce D. Lindsay,Moussa Mansour,Francis E. Marchlinski,Patrick M. McCarthy,J. Lluis Mont,Fred Morady,Koonlawee Nademanee,Hiroshi Nakagawa,Andrea Natale,Stanley Nattel,Douglas L. Packer,Carlo Pappone,Eric N. Prystowsky,Antonio Raviele,Vivek Y. Reddy,Jeremy N. Ruskin,Richard J. Shemin,Hsuan Ming Tsao,David J. Wilber,Niv Ad,Jennifer E. Cummings,A. Mark Gillinov,Hein Heidbuchel,Craig T. January,Gregory Y.H. Lip,Steven M. Markowitz,Mohan Nair,I. Eli Ovsyshcher,Hui Nam Pak,Takeshi Tsuchiya,Dipen Shah,Teo Wee Siong,Panos E. Vardas +60 more
TL;DR: This 2012 Consensus Statement is to provide a state-of-the-art review of the field of catheter and surgical ablation of AF and to report the findings of a Task Force, convened by the Heart Rhythm Society, the European Heart Rhythm Association, and the European Cardiac Arrhythmia Society and charged with defining the indications, techniques, and outcomes of this procedure.
Journal ArticleDOI
2014 AHA/ACC/HRS Guideline for the Management of Patients With Atrial Fibrillation: Executive Summary
Craig T. January,L. Samuel Wann,Joseph S. Alpert,Hugh Calkins,Joaquin E. Cigarroa,Joseph C. Cleveland,Jamie B. Conti,Patrick T. Ellinor,Michael D. Ezekowitz,Michael E. Field,Katherine T. Murray,Ralph L. Sacco,William G. Stevenson,Patrick J. Tchou,Cynthia M. Tracy,Clyde W. Yancy +15 more
TL;DR: The medical profession should play a central role in evaluating the evidence related to drugs, devices, and procedures for the detection, management, and prevention of disease.
Journal ArticleDOI
2017 HRS / EHRA / ECAS / APHRS / SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation
Hugh Calkins,Gerhard Hindricks,Riccardo Cappato,Young Hoon Kim,Eduardo B. Saad,Luis Aguinaga,Joseph G. Akar,Vinay Badhwar,Josep Brugada,John Camm,Peng Sheng Chen,Shih Ann Chen,Mina K. Chung,Jens Cosedis Nielsen,Anne B. Curtis,D. Wyn Davies,John D. Day,Andre d'Avila,N. M. S. de Groot,Luigi Di Biase,Mattias Duytschaever,James R. Edgerton,Kenneth A. Ellenbogen,Patrick T. Ellinor,Sabine Ernst,Guilherme Fenelon,Edward P. Gerstenfeld,David E. Haines,Michel Haïssaguerre,Robert H. Helm,Elaine M. Hylek,Warren M. Jackman,José Jalife,José Jalife,Jonathan M. Kalman,Josef Kautzner,Hans Kottkamp,Karl Heinz Kuck,Koichiro Kumagai,Richard Lee,Thorsten Lewalter,Bruce D. Lindsay,Laurent Macle,Moussa Mansour,Francis E. Marchlinski,Gregory F. Michaud,Hiroshi Nakagawa,Andrea Natale,Stanley Nattel,Ken Okumura,Douglas L. Packer,Evgeny Pokushalov,Matthew R. Reynolds,Prashanthan Sanders,Mauricio Scanavacca,Richard J. Schilling,Claudio Tondo,Hsuan Ming Tsao,Atul Verma,David J. Wilber,Teiichi Yamane +60 more
TL;DR: This 2017 Consensus Statement is to provide a state-of-the-art review of the field of catheter and surgical ablation of AF and to report the findings of a writing group, convened by these five international societies.
Journal ArticleDOI
2012 HRS/EHRA/ECAS Expert Consensus Statement on Catheter and Surgical Ablation of Atrial Fibrillation: Recommendations for Patient Selection, Procedural Techniques, Patient Management and Follow-up, Definitions, Endpoints, and Research Trial Design
Hugh Calkins,Hugh Calkins,Karl Heinz Kuck,Riccardo Cappato,Josep Brugada,A. John Camm,Shih Ann Chen,Harry J.G.M. Crijns,Ralph J. Damiano,D. Wyn Davies,John P. DiMarco,James R. Edgerton,Kenneth A. Ellenbogen,Michael D. Ezekowitz,David E. Haines,Michel Haïssaguerre,Gerhard Hindricks,Yoshito Iesaka,Warren M. Jackman,José Jalife,Pierre Jaïs,Jonathan M. Kalman,David Keane,Young Hoon Kim,Paulus Kirchhof,Paulus Kirchhof,George J. Klein,Hans Kottkamp,Koichiro Kumagai,Bruce D. Lindsay,Moussa Mansour,Francis E. Marchlinski,Patrick M. McCarthy,J. Lluis Mont,Fred Morady,Koonlawee Nademanee,Hiroshi Nakagawa,Andrea Natale,Stanley Nattel,Douglas L. Packer,Carlo Pappone,Eric N. Prystowsky,Antonio Raviele,Vivek Y. Reddy,Jeremy N. Ruskin,Richard J. Shemin,Hsuan Ming Tsao,David J. Wilber,David J. Wilber +48 more
TL;DR: A report of the Heart Rhythm Society (HRS) Task Force on Catheter and Surgical Ablation of Atrial Fibrillation, developed in partnership with the European Heart Rhythm Association (EHRA), a registered branch of the European Society of Cardiology and the European Cardiac Arrhythmia Society (ECAS), was published in this paper.
References
More filters
Journal ArticleDOI
Pitx2c and Nkx2-5 Are Required for the Formation and Identity of the Pulmonary Myocardium
Mathilda T.M. Mommersteeg,Nigel A. Brown,Owen W.J. Prall,Corrie de Gier-de Vries,Richard P. Harvey,Antoon F.M. Moorman,Vincent M. Christoffels +6 more
TL;DR: A cellular mechanism for pulmonary myocardium formation is suggested and the key roles played by Pitx2c and Nkx2-5 in its formation and identity are highlighted.
Journal ArticleDOI
Molecular Pathway for the Localized Formation of the Sinoatrial Node
Mathilda T.M. Mommersteeg,Willem M.H. Hoogaars,Owen W.J. Prall,Corrie de Gier-de Vries,Cornelia Wiese,Danielle E.W. Clout,Virginia E. Papaioannou,Nigel A. Brown,Richard P. Harvey,Antoon F.M. Moorman,Vincent M. Christoffels +10 more
TL;DR: The molecular pathway provides a mechanism for how pacemaker activity becomes progressively relegated to the most recently added components of the venous pole of the heart and, ultimately, to the junction of the right atrium and superior caval vein.
Journal ArticleDOI
CaMKII-Dependent Diastolic SR Ca2+ Leak and Elevated Diastolic Ca2+ Levels in Right Atrial Myocardium of Patients With Atrial Fibrillation
Stefan Neef,Nataliya Dybkova,Samuel Sossalla,Katharina Ort,Nina Fluschnik,Kay Neumann,Ralf Seipelt,Friedrich A. Schöndube,Gerd Hasenfuss,Lars S. Maier +9 more
TL;DR: In this article, the authors tested the hypothesis that CaMKII-dependent diastolic sarcoplasmic reticulum (SR) Ca2+ leak and elevated dastolic ca2+ levels occurs in atrial myocardium of patients with AF.
Journal ArticleDOI
Defective Cardiac Ryanodine Receptor Regulation During Atrial Fibrillation
John A. Vest,Xander H.T. Wehrens,Steven Reiken,Stephan E. Lehnart,Dobromir Dobrev,Parag Chandra,Peter Danilo,Ursula Ravens,M R Rosen,Andrew R. Marks +9 more
TL;DR: Atrial tissue from both the AF dogs and humans with chronic AF showed a significant increase in PKA phosphorylation of RyR2, with a corresponding decrease in calstabin2 binding to the channel.
Journal ArticleDOI
Molecular Basis of Downregulation of G-Protein–Coupled Inward Rectifying K+ Current (IK,ACh) in Chronic Human Atrial Fibrillation Decrease in GIRK4 mRNA Correlates With Reduced IK,ACh and Muscarinic Receptor–Mediated Shortening of Action Potentials
Dobromir Dobrev,Eva M. Graf,Erich Wettwer,Herbert Himmel,Ottó Hála,C. Doerfel,Torsten Christ,S. Schüler,Ursula Ravens +8 more
TL;DR: It is suggested that atrial myocytes adapt to a chronically high rate by downregulating IK,ACh to counteract the shortening of the atrial effective refractory period due to electrical remodeling.