Recent advances in the molecular pathophysiology of atrial fibrillation
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TLDR
The ways in which cardiac disease states, extracardiac factors, and abnormal genetic control lead to the arrhythmia are discussed, including the potential therapeutic implications that might arise from an improved mechanistic understanding.Abstract:
Atrial fibrillation (AF) is an extremely common cardiac rhythm disorder that causes substantial morbidity and contributes to mortality. The mechanisms underlying AF are complex, involving both increased spontaneous ectopic firing of atrial cells and impulse reentry through atrial tissue. Over the past ten years, there has been enormous progress in understanding the underlying molecular pathobiology. This article reviews the basic mechanisms and molecular processes causing AF. We discuss the ways in which cardiac disease states, extracardiac factors, and abnormal genetic control lead to the arrhythmia. We conclude with a discussion of the potential therapeutic implications that might arise from an improved mechanistic understanding.read more
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Journal ArticleDOI
2014 AHA/ACC/HRS Guideline for the Management of Patients With Atrial Fibrillation: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the Heart Rhythm Society
Craig T. January,L. Samuel Wann,Joseph S. Alpert,Hugh Calkins,Joaquin E. Cigarroa,Joseph C. Cleveland,Jamie B. Conti,Patrick T. Ellinor,Michael D. Ezekowitz,Michael E. Field,Katherine T. Murray,Ralph L. Sacco,William G. Stevenson,Patrick J. Tchou,Cynthia M. Tracy,Clyde W. Yancy +15 more
TL;DR: This document summarizes current research, plans, and recommendations for future research, as well as providing a history of the field and some of the techniques used, currently in use, at the National Institutes of Health.
Journal ArticleDOI
2012 HRS/EHRA/ECAS expert consensus statement on catheter and surgical ablation of atrial fibrillation: Recommendations for patient selection, procedural techniques, patient management and follow-up, definitions, endpoints, and research trial design
Hugh Calkins,Karl-Heinz Kuck,Riccardo Cappato,Josep Brugada,A. John Camm,Shih Ann Chen,Harry J.G.M. Crijns,Ralph J. Damiano,D. Wyn Davies,John P. DiMarco,James R. Edgerton,Kenneth A. Ellenbogen,Michael D. Ezekowitz,David E. Haines,Michel Haïssaguerre,Gerhard Hindricks,Yoshito Iesaka,Warren M. Jackman,José Jalife,Pierre Jaïs,Jonathan M. Kalman,David Keane,Younghoon Kim,Paulus Kirchhof,Paulus Kirchhof,George J. Klein,Hans Kottkamp,Koichiro Kumagai,Bruce D. Lindsay,Moussa Mansour,Francis E. Marchlinski,Patrick M. McCarthy,J. Lluis Mont,Fred Morady,Koonlawee Nademanee,Hiroshi Nakagawa,Andrea Natale,Stanley Nattel,Douglas L. Packer,Carlo Pappone,Eric N. Prystowsky,Antonio Raviele,Vivek Y. Reddy,Jeremy N. Ruskin,Richard J. Shemin,Hsuan Ming Tsao,David J. Wilber,Niv Ad,Jennifer E. Cummings,A. Mark Gillinov,Hein Heidbuchel,Craig T. January,Gregory Y.H. Lip,Steven M. Markowitz,Mohan Nair,I. Eli Ovsyshcher,Hui Nam Pak,Takeshi Tsuchiya,Dipen Shah,Teo Wee Siong,Panos E. Vardas +60 more
TL;DR: This 2012 Consensus Statement is to provide a state-of-the-art review of the field of catheter and surgical ablation of AF and to report the findings of a Task Force, convened by the Heart Rhythm Society, the European Heart Rhythm Association, and the European Cardiac Arrhythmia Society and charged with defining the indications, techniques, and outcomes of this procedure.
Journal ArticleDOI
2014 AHA/ACC/HRS Guideline for the Management of Patients With Atrial Fibrillation: Executive Summary
Craig T. January,L. Samuel Wann,Joseph S. Alpert,Hugh Calkins,Joaquin E. Cigarroa,Joseph C. Cleveland,Jamie B. Conti,Patrick T. Ellinor,Michael D. Ezekowitz,Michael E. Field,Katherine T. Murray,Ralph L. Sacco,William G. Stevenson,Patrick J. Tchou,Cynthia M. Tracy,Clyde W. Yancy +15 more
TL;DR: The medical profession should play a central role in evaluating the evidence related to drugs, devices, and procedures for the detection, management, and prevention of disease.
Journal ArticleDOI
2017 HRS / EHRA / ECAS / APHRS / SOLAECE expert consensus statement on catheter and surgical ablation of atrial fibrillation
Hugh Calkins,Gerhard Hindricks,Riccardo Cappato,Young Hoon Kim,Eduardo B. Saad,Luis Aguinaga,Joseph G. Akar,Vinay Badhwar,Josep Brugada,John Camm,Peng Sheng Chen,Shih Ann Chen,Mina K. Chung,Jens Cosedis Nielsen,Anne B. Curtis,D. Wyn Davies,John D. Day,Andre d'Avila,N. M. S. de Groot,Luigi Di Biase,Mattias Duytschaever,James R. Edgerton,Kenneth A. Ellenbogen,Patrick T. Ellinor,Sabine Ernst,Guilherme Fenelon,Edward P. Gerstenfeld,David E. Haines,Michel Haïssaguerre,Robert H. Helm,Elaine M. Hylek,Warren M. Jackman,José Jalife,José Jalife,Jonathan M. Kalman,Josef Kautzner,Hans Kottkamp,Karl Heinz Kuck,Koichiro Kumagai,Richard Lee,Thorsten Lewalter,Bruce D. Lindsay,Laurent Macle,Moussa Mansour,Francis E. Marchlinski,Gregory F. Michaud,Hiroshi Nakagawa,Andrea Natale,Stanley Nattel,Ken Okumura,Douglas L. Packer,Evgeny Pokushalov,Matthew R. Reynolds,Prashanthan Sanders,Mauricio Scanavacca,Richard J. Schilling,Claudio Tondo,Hsuan Ming Tsao,Atul Verma,David J. Wilber,Teiichi Yamane +60 more
TL;DR: This 2017 Consensus Statement is to provide a state-of-the-art review of the field of catheter and surgical ablation of AF and to report the findings of a writing group, convened by these five international societies.
Journal ArticleDOI
2012 HRS/EHRA/ECAS Expert Consensus Statement on Catheter and Surgical Ablation of Atrial Fibrillation: Recommendations for Patient Selection, Procedural Techniques, Patient Management and Follow-up, Definitions, Endpoints, and Research Trial Design
Hugh Calkins,Hugh Calkins,Karl Heinz Kuck,Riccardo Cappato,Josep Brugada,A. John Camm,Shih Ann Chen,Harry J.G.M. Crijns,Ralph J. Damiano,D. Wyn Davies,John P. DiMarco,James R. Edgerton,Kenneth A. Ellenbogen,Michael D. Ezekowitz,David E. Haines,Michel Haïssaguerre,Gerhard Hindricks,Yoshito Iesaka,Warren M. Jackman,José Jalife,Pierre Jaïs,Jonathan M. Kalman,David Keane,Young Hoon Kim,Paulus Kirchhof,Paulus Kirchhof,George J. Klein,Hans Kottkamp,Koichiro Kumagai,Bruce D. Lindsay,Moussa Mansour,Francis E. Marchlinski,Patrick M. McCarthy,J. Lluis Mont,Fred Morady,Koonlawee Nademanee,Hiroshi Nakagawa,Andrea Natale,Stanley Nattel,Douglas L. Packer,Carlo Pappone,Eric N. Prystowsky,Antonio Raviele,Vivek Y. Reddy,Jeremy N. Ruskin,Richard J. Shemin,Hsuan Ming Tsao,David J. Wilber,David J. Wilber +48 more
TL;DR: A report of the Heart Rhythm Society (HRS) Task Force on Catheter and Surgical Ablation of Atrial Fibrillation, developed in partnership with the European Heart Rhythm Association (EHRA), a registered branch of the European Society of Cardiology and the European Cardiac Arrhythmia Society (ECAS), was published in this paper.
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