scispace - formally typeset
Journal ArticleDOI

Regulation of epithelial calcium transport by prolactin: From fish to mammals

Reads0
Chats0
TLDR
The cellular and molecular mechanisms of the PRL-stimulated calcium transport in mammals have been elaborated and it is demonstrated that the duodenal calcium absorption in lactating rats was markedly enhanced by the suckling-induced PRL surge, presumably to provide calcium for milk production.
About
This article is published in General and Comparative Endocrinology.The article was published on 2013-01-15. It has received 24 citations till now. The article focuses on the topics: Calcium & Calcium metabolism.

read more

Citations
More filters
Journal ArticleDOI

Molecular aspects of intestinal calcium absorption.

TL;DR: Better knowledge of the molecular details of intestinal Ca(2+) absorption could lead to the development of nutritional and medical strategies for optimizing the efficiency of intestinal calcium absorption and preventing osteoporosis and other pathologies related to Ca( 2+) metabolism.
Book ChapterDOI

Vitamin D-enhanced duodenal calcium transport.

TL;DR: Vitamin D-independent calcium absorption does exist and plays an important role in calcium homeostasis under certain conditions, particularly in neonatal period, pregnancy, and lactation as well as in naturally vitamin D-impoverished subterranean mammals.
Journal ArticleDOI

What Is Breast in the Bone

TL;DR: The role of prolactin in breast development, bone homeostasis and in breast cancer to bone metastases is focused on, covering the molecular aspects of the vicious cycle.
References
More filters
Journal ArticleDOI

Prolactin (PRL) and Its Receptor: Actions, Signal Transduction Pathways and Phenotypes Observed in PRL Receptor Knockout Mice

TL;DR: It is clear that there are multiple actions associated with PRL, and the technique of gene targeting in mice has been used to develop the first experimental model in which the effect of the complete absence of any lactogen or PRL-mediated effects can be studied.
Journal ArticleDOI

Physiology and Function of the Tight Junction

TL;DR: Current information suggests that the paracellular barrier is most usefully modeled as having two physiologic components: a system of charge-selective small pores, 4 A in radius, and a second pathway created by larger discontinuities in the barrier, lacking charge or size discrimination.
Journal ArticleDOI

The amphioxus genome illuminates vertebrate origins and cephalochordate biology

Linda Z. Holland, +71 more
- 01 Jul 2008 - 
TL;DR: The results indicate that the amphioxus genome is elemental to an understanding of the biology and evolution of nonchordate deuterostomes, invertebrate chordates, and vertebrates.
Journal ArticleDOI

Tight junction proteins claudin-2 and -12 are critical for vitamin D-dependent Ca2+ absorption between enterocytes.

TL;DR: It is shown, by using RNA interference and overexpression strategies, that claud in-2 and claudin-12 contribute to Ca(2+) absorption in intestinal epithelial cells, and a novel mechanism behind vitamin D-dependent calcium homeostasis is highlighted.
Journal ArticleDOI

The role of prolactin in fish osmoregulation: a review.

TL;DR: Much of the recent work has focused on the isolation and characterization of fish PRLs and their receptors, which have provided the necessary tools to obtain a better understanding of the evolution of PRL and its role in osmoregulation.
Related Papers (5)