Regulation of miR-200 family microRNAs and ZEB transcription factors in ovarian cancer: evidence supporting a mesothelial-to-epithelial transition
Ausra Bendoraite,Emily C. Knouf,Kavita Garg,Rachael K. Parkin,Evan M. Kroh,Kathy O'Briant,Aviva P. Ventura,Andrew K. Godwin,Beth Y. Karlan,Charles W. Drescher,Nicole Urban,Beatrice S. Knudsen,Muneesh Tewari +12 more
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TLDR
Analysis of ovarian cancer tissues suggests that ovarian surface cells acquire a more epithelial miR-200-ZEB1/2 phenotype as they undergo transformation, suggesting the mesothelial-to-epithelial (Meso-E-T) model for development of ovarian cancers that arise from ovariansurface cells, as has been proposed previously on the basis of studies of protein markers.About:
This article is published in Gynecologic Oncology.The article was published on 2010-01-01 and is currently open access. It has received 197 citations till now. The article focuses on the topics: Ovarian cancer & Cancer cell.read more
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Journal ArticleDOI
miRNAs in human cancer.
TL;DR: A critical overview of miRNA dysregulation in cancer is provided, first discussing the methods currently available for studying the role of miRNAs in cancer and then reviewing miRNA genomic organization, biogenesis and mechanism of target recognition.
Journal ArticleDOI
The ZEB/miR‐200 feedback loop—a motor of cellular plasticity in development and cancer?
Simone Brabletz,Thomas Brabletz +1 more
TL;DR: It is proposed that the ZEB/miR‐200 feedback loop is the molecular motor of cellular plasticity in development and disease, and in particular is a driving force for cancer progression towards metastasis by controlling the state of cancer stem cells.
Book ChapterDOI
microRNAs in Human Cancer
TL;DR: A critical overview of miRNA dysregulation in cancer is provided, first discussing the methods currently available for studying the role of miRNAs in cancer and then reviewing miRNA genomic organization, biogenesis, and mechanism of target recognition.
Journal ArticleDOI
To differentiate or not — routes towards metastasis
TL;DR: Two principle types of metastatic progression are proposed: phenotypic plasticity involving transient EMT–MET processes and intrinsic genetic alterations keeping cells in an EMT and stemness state.
Journal ArticleDOI
miR-141 and miR-200a act on ovarian tumorigenesis by controlling oxidative stress response.
Bogdan Mateescu,Bogdan Mateescu,Luciana Batista,Luciana Batista,Melissa Cardon,Melissa Cardon,Tina Gruosso,Tina Gruosso,Yvan de Feraudy,Yvan de Feraudy,Odette Mariani,André Nicolas,Jean-Philippe Meyniel,Paul Cottu,Xavier Sastre-Garau,Fatima Mechta-Grigoriou,Fatima Mechta-Grigoriou +16 more
TL;DR: Show crosstalk between oxidative stress and the miR-200 family of microRNAs that affects tumorigenesis and chemosensitivity and the role of miR200a in stress could be a predictive marker for clinical outcome in ovarian cancer.
References
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TL;DR: Although they escaped notice until relatively recently, miRNAs comprise one of the more abundant classes of gene regulatory molecules in multicellular organisms and likely influence the output of many protein-coding genes.
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Oncomirs : microRNAs with a role in cancer
TL;DR: I MicroRNAs (miRNAs) are an abundant class of small non-protein-coding RNAs that function as negative gene regulators as discussed by the authors, and have been shown to repress the expression of important cancer-related genes and might prove useful in the diagnosis and treatment of cancer.
Journal ArticleDOI
Oncomirs — microRNAs with a role in cancer
TL;DR: Evidence has shown that miRNA mutations or mis-expression correlate with various human cancers and indicates that miRNAs can function as tumour suppressors and oncogenes.