Regulatory non-coding transcripts in spermatogenesis: shedding light on 'dark matter'.
TLDR
Recent progress in understanding about the involvement of ncRNAs including microRNAs, PIWI‐interacting RNAs, endogenous small‐interfering RNAs and long non‐coding RNAs as controller of gene expression at transcriptional as well as post‐transcriptional level in different biological context and disease processes is discussed.Abstract:
Global rise in male infertility over the past decades as a result of falling sperm count and quality has been pointed out by different investigations. Therefore, it is important to understand the molecular mechanism of spermatogenesis and its regulation. Mammalian spermatogenesis, a streamlined process through which male germline cells divide and differentiate into mature spermatozoa, is strictly regulated by phase-specific gene expression which, in turn, is controlled by myriads of regulatory non-coding RNAs (ncRNAs). Rapid advancement in genome mining technologies has identified role of ncRNAs including microRNAs, PIWI-interacting RNAs, endogenous small-interfering RNAs and long non-coding RNAs as controller of gene expression at transcriptional as well as post-transcriptional level in different biological context and disease processes. Here, we discuss the recent progress in our understanding about the involvement of these molecules in spermatogenesis. In addition, we describe here the possible roles of long non-coding RNAs in controlling this process which is not delved so far.read more
Citations
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Identification and characterization of human testis derived circular RNAs and their existence in seminal plasma
TL;DR: This work has laid the foundations to decipher regulation mechanisms of circRNAs in spermatogenesis and to develop circ RNAs as novel noninvasive biomarkers for male infertile diseases.
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Spermatozoa from patients with seminal alterations exhibit a differential micro-ribonucleic acid profile
Albert Salas-Huetos,Joan Blanco,Francesca Vidal,Anna Godo,Mark Grossmann,Maria Carme Pons,Silvia F-Fernández,Nicolás Garrido,Ester Anton +8 more
TL;DR: Spermatozoa from patients with seminal alterations exhibit a differential miRNA profile, providing new evidence that miRNAs have an essential role in spermatogenesis, contributing to the mechanisms involved in human fertility.
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Environmentally induced epigenetic toxicity: potential public health concerns.
TL;DR: The present understanding of epigenetic mechanisms involved in the mammalian life cycle is examined, the current evidence for environmentally induced epigenetic toxicity in human cohorts and rodent models is evaluated, and the research considerations and implications of this emerging knowledge for public health and regulatory toxicology are highlighted.
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