Reward circuitry responsivity to food predicts future increases in body mass: moderating effects of DRD2 and DRD4.
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TLDR
This novel prospective fMRI study indicates that responsivity of reward circuitry to food increases risk for future weight gain, but that genes that impact dopamine signaling capacity moderate the predictive effects, suggesting two qualitatively distinct pathways to unhealthy weight gain based on genetic risk.About:
This article is published in NeuroImage.The article was published on 2010-05-01 and is currently open access. It has received 311 citations till now.read more
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Functional brain imaging of appetite
TL;DR: The recent use of functional brain imaging in humans to study the neural control of appetite is reviewed, and how the neural systems involved may cause vulnerability to overeating in the obesogenic environment is reviewed.
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Reward abnormalities among women with full and subthreshold bulimia nervosa: a functional magnetic resonance imaging study.
Cara Bohon,Eric Stice +1 more
TL;DR: It is shown that bulimia nervosa may be related to potential hypofunctioning of the brain reward system, which may lead these individuals to binge eat to compensate for this reward deficit, though the hypo-responsivity might be a result of a history of binge eating highly palatable foods.
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Dopamine signaling in food addiction: role of dopamine D2 receptors.
TL;DR: This review focuses on the functions of the DA system, with specific focus on the physiological interpretation and the role of DA D2 receptor signaling in food addiction.
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Variability in Reward Responsivity and Obesity: Evidence from Brain Imaging Studies
Kyle S. Burger,Eric Stice +1 more
TL;DR: A dynamic vulnerability model of obesity appears to offer a parsimonious theory that accommodates extant findings and is presented as a viable alternative to various models of obesity's relation to reward from food.
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"You Say it's Liking, I Say it's Wanting …". On the difficulty of disentangling food reward in man.
TL;DR: It is concluded that it is important to assess appetite and palatability in the study of reward driven eating, but determining whether these measurements reflect either food 'wanting' or food 'liking' is not.
References
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Book
Applied Linear Statistical Models
TL;DR: Applied Linear Statistical Models 5e as discussed by the authors is the leading authoritative text and reference on statistical modeling, which includes brief introductory and review material, and then proceeds through regression and modeling for the first half, and through ANOVA and Experimental Design in the second half.
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Applied Linear Statistical Models
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Analysis of fMRI time-series revisited--again.
Keith J. Worsley,Karl J. Friston +1 more
TL;DR: Correct results are presented that replace those of the previous paper and solve the same problem without recourse to heuristic arguments and a proper and unbiased estimator for the error terms are introduced.
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Brain dopamine and obesity.
Gene-Jack Wang,Gene-Jack Wang,Nora D. Volkow,Nora D. Volkow,Jean Logan,Naoml R Pappas,Christopher Wong,Wel Zhu,Noelwah Netusll,Joanna S. Fowler +9 more
TL;DR: Dopamine modulates motivation and reward circuits and hence dopamine deficiency in obese individuals may perpetuate pathological eating as a means to compensate for decreased activation of these circuits.
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Allelic discrimination using fluorogenic probes and the 5' nuclease assay.
TL;DR: The 5' nuclease (TaqMan) as discussed by the authors is a typical PCR that uses a fluorogenic probe, consisting of an oligonucleotide labeled with both a fluorescent reporter dye and a quencher dye.