Reward circuitry responsivity to food predicts future increases in body mass: moderating effects of DRD2 and DRD4.
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TLDR
This novel prospective fMRI study indicates that responsivity of reward circuitry to food increases risk for future weight gain, but that genes that impact dopamine signaling capacity moderate the predictive effects, suggesting two qualitatively distinct pathways to unhealthy weight gain based on genetic risk.About:Â
This article is published in NeuroImage.The article was published on 2010-05-01 and is currently open access. It has received 311 citations till now.read more
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Journal ArticleDOI
Altered hypothalamic response to food in smokers
TL;DR: Smokers display an altered brain response to food in the hypothalamus, which is an area associated with long-term weight change in nonsmokers.
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What you see is what you eat: an ALE meta-analysis of the neural correlates of food viewing in children and adolescents.
TL;DR: The brain areas most consistently activated in children/adolescents by food viewing are part of the appetitive brain network and overlap with those found in adults, however, the age range of the children studied was rather broad.
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Appetitive traits from infancy to adolescence: using behavioral and neural measures to investigate obesity risk.
TL;DR: This approach may help to identify the biobehavioral precursors of obesity, and lay the foundations for targeted neurobehavioral interventions that can interrupt the pathway to excess weight.
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Methylation of the dopamine D2 receptor (DRD2) gene promoter in women with a bulimia-spectrum disorder: Associations with borderline personality disorder and exposure to childhood abuse
Patricia Groleau,Patricia Groleau,Ridha Joober,Mimi Israel,Mimi Israel,Nadia Zeramdini,Rosherrie DeGuzman,Howard Steiger +7 more
TL;DR: The findings imply that, in people with a BSD, increased methylation of the DRD2 gene promoter may be more strongly characteristic of comorbid psychopathology than it is a global correlate of the eating disorder per se.
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Recovery of brain structural abnormalities in morbidly obese patients after bariatric surgery.
Yi Zhang,Gang Ji,Xu Mao,Cai W,Zhu Q,Long Qian,Zhang Ye,Kai Yuan,Jixin Liu,Li Q,Guangbin Cui,Huaning Wang,Qingchuan Zhao,Kaichun Wu,Fan D,Mark S. Gold,Jie Tian,Jie Tian,Dardo Tomasi,Liu Y,Liu Y,Yongzhan Nie,Gene-Jack Wang +22 more
TL;DR: This study provides the first anatomical evidence for BS-induced acute neuroplastic recovery that might in part mediate the long-term benefit of BS in weight reduction and highlights the importance of this line of gut–brain axis research employing the combined BS and neuroimaging model for identifying longitudinal changes in brain structure that correlated with obesity status.
References
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Book
Applied Linear Statistical Models
TL;DR: Applied Linear Statistical Models 5e as discussed by the authors is the leading authoritative text and reference on statistical modeling, which includes brief introductory and review material, and then proceeds through regression and modeling for the first half, and through ANOVA and Experimental Design in the second half.
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Applied Linear Statistical Models
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Analysis of fMRI time-series revisited--again.
Keith J. Worsley,Karl J. Friston +1 more
TL;DR: Correct results are presented that replace those of the previous paper and solve the same problem without recourse to heuristic arguments and a proper and unbiased estimator for the error terms are introduced.
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Brain dopamine and obesity.
Gene-Jack Wang,Gene-Jack Wang,Nora D. Volkow,Nora D. Volkow,Jean Logan,Naoml R Pappas,Christopher Wong,Wel Zhu,Noelwah Netusll,Joanna S. Fowler +9 more
TL;DR: Dopamine modulates motivation and reward circuits and hence dopamine deficiency in obese individuals may perpetuate pathological eating as a means to compensate for decreased activation of these circuits.
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Allelic discrimination using fluorogenic probes and the 5' nuclease assay.
TL;DR: The 5' nuclease (TaqMan) as discussed by the authors is a typical PCR that uses a fluorogenic probe, consisting of an oligonucleotide labeled with both a fluorescent reporter dye and a quencher dye.