Reward circuitry responsivity to food predicts future increases in body mass: moderating effects of DRD2 and DRD4.
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TLDR
This novel prospective fMRI study indicates that responsivity of reward circuitry to food increases risk for future weight gain, but that genes that impact dopamine signaling capacity moderate the predictive effects, suggesting two qualitatively distinct pathways to unhealthy weight gain based on genetic risk.About:
This article is published in NeuroImage.The article was published on 2010-05-01 and is currently open access. It has received 311 citations till now.read more
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A Behavioral Genetic Model of the Mechanisms Underlying the Link Between Obesity and Symptoms of ADHD.
Karen A. Patte,Caroline Davis,Caroline Davis,Caroline Davis,Robert D. Levitan,Robert D. Levitan,Allan S. Kaplan,Allan S. Kaplan,Jacqueline C. Carter-Major,James L. Kennedy,James L. Kennedy +10 more
TL;DR: Results support the hypothesis that overeating and elevated DA in the ventral striatum—representative of a greater reward response—contribute to the ADHD symptom–obesity relationship.
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Spontaneous regional brain activity links restrained eating to later weight gain among young women
TL;DR: In this article, resting fMRI was used to test the extent to which spontaneous neural activity in regions associated with inhibitory control and food reward account for potential relations between baseline restrained eating levels and changes in body weight among dieters over a one-year interval.
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Massive weight loss following deep brain stimulation of the nucleus accumbens in a depressed woman.
Volker M. Tronnier,Dirk Rasche,Veronika Thorns,Daniel Alvarez-Fischer,Thomas F. Münte,Bartosz Zurowski +5 more
TL;DR: The current case suggests that DBS of the NAcc warrants further evaluation in patients unresponsive to other treatments, including treatment-resistant depression as well as severe obesity.
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Prefrontal cortex-mediated executive function as assessed by Stroop task performance associates with weight loss among overweight and obese adolescents and young adults.
TL;DR: Overall, the results support a role for prefrontal cortex‐mediated EF in influencing food intake and weight loss outcomes in a population of a previously unstudied age.
Journal ArticleDOI
The associations among the dopamine D2 receptor Taq1, emotional intelligence, creative potential measured by divergent thinking, and motivational state and these associations' sex differences
Hikaru Takeuchi,Hiroaki Tomita,Yasuyuki Taki,Yoshie Kikuchi,Chiaki Ono,Zhiqian Yu,Atsushi Sekiguchi,Rui Nouchi,Yuka Kotozaki,Seishu Nakagawa,Carlos Makoto Miyauchi,Kunio Iizuka,Ryoichi Yokoyama,Takamitsu Shinada,Yuki Yamamoto,Sugiko Hanawa,Tsuyoshi Araki,Hiroshi Hashizume,Keiko Kunitoki,Yuko Sassa,Ryuta Kawashima +20 more
TL;DR: Path analysis in females indicates that the model in which the DRD2 polymorphism primarily facilitates EI, EI in turn facilitates CPMDT and leads to a better motivational state, and a best motivational state also directly facilitates C PMDT explains the data in the most accurate manner.
References
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Book
Applied Linear Statistical Models
TL;DR: Applied Linear Statistical Models 5e as discussed by the authors is the leading authoritative text and reference on statistical modeling, which includes brief introductory and review material, and then proceeds through regression and modeling for the first half, and through ANOVA and Experimental Design in the second half.
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Applied Linear Statistical Models
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Keith J. Worsley,Karl J. Friston +1 more
TL;DR: Correct results are presented that replace those of the previous paper and solve the same problem without recourse to heuristic arguments and a proper and unbiased estimator for the error terms are introduced.
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Gene-Jack Wang,Gene-Jack Wang,Nora D. Volkow,Nora D. Volkow,Jean Logan,Naoml R Pappas,Christopher Wong,Wel Zhu,Noelwah Netusll,Joanna S. Fowler +9 more
TL;DR: Dopamine modulates motivation and reward circuits and hence dopamine deficiency in obese individuals may perpetuate pathological eating as a means to compensate for decreased activation of these circuits.
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